This reference spotlights the immunologic aspects of applying interferon-gamma to the treatment of infectious diseases - revealing the current knowledge of the biology and potential utility of interferon-gamma.;Written by more than 30 leading investigators in the field, Anti-Infective Applications of Interferon-Gamma: presents information according to specific patient populations and pathogens; focuses on only the most promising of emerging therapeutic agents; furnishes a detailed update of the pleiotropic role of interferon-gamma in host defense; and studies clinical and preclinical experiences in a broad variety of disease indications.;Containing over 900 bibliographic citations for further research, this book should be useful for infectious disease specialists, pharmacologists, immunologists, surgeons, pediatricians, parasitologists, hematologists, virologists, microbiologists, pathologists, oncologists and tropical medicine specialists.
The interferons - a clinical overview, Howard S. Jaffe. Part 1 Target populations: interferon-gamma treatment of chronic granulomatous disease, Allen E. Izu, et al; infection associated with the surgical care of the major trauma victim, Hiram C. Polk, et al; potential role of interferon-gamma in human immunodeficiency virus-associated disease, David Aboulafia and Ronald T. Mitsuyasu; interferon-gamma in the neonate, Harry R. Hill; atopic dermatitis, Mark Boguniewicz and Donald Leung. Part 2 Target infections: protozoan infections - the role of interferon-gamma in resistance against toxoplasma gondii, Carlos S. Subauste and Jack S. Remington, leishmaniasis and interferon-gamma, Susan M. Kramer, interferon-gamma in trypanosoma cruzi infections, Steven G. Reed and Joao Santana da Silva, interferon-gamma and immunity to malaria sporozoites - implications for the development of synthetic vaccines, Louis Schofield; viral infections - interferon-gamma for human papillomavirus infection, Philip Kirby and Lawrence Corey, herpes simplex as a target for anti-infective applications of interferon-gamma - perclinical in vitro and in vivo observations, Ann M. Arvin, the role of interferon in cytomegalovirus infection, Richard C. Gehrz, interferons and Epstein-Barr virus infection, Motohiko Okano and David T. Purtilo; bacterial infections - treatment of lepromatous leprosy within recombinant interferon-gamma, Carl F. Nathan, interferon-gamma and the control of intracellular chlamydia replication, Gerald I. Byrne and Julius Schachter, influence of interferon-gamma on legionella pneumophilia - mononuclear phagocyte interaction, Marcus A. Horwitz; fungal infections - interferon-gamma and fungal infections, David A. Stevens. Part 3 Target treatment strategies: interferon-gamma as an adjuvant for vaccines, A.W. Heath and J.H.L. Playfair.