In the past years, COVID-19 caused millions of deaths and severely damaged not only public health, but also the global economy. New variants continue to threaten human health. Thus, natural compounds for retarding infection are in high demand. This book summarizes the emerging research with flavonoids, whose application holds great promise of antivirus, anti-inflammation, antioxidative stress, and immunomodulatory. Topics include the role of flavonoids in preventing an inflammatory storm and how flavonoids interact with critical protein targets that are involved in the infection stages of COVID-19.
Key Features
• Highlights anti-SARS-CoV-2 research drug discovery on natural products and medicinal plants
• Includes all major subclasses of flavonoids that promisingly combat COVID-19
• Proposes molecular mechanisms of flavonoids against protein targets of SARS-CoV-2
• Contributions from an international team of leading researchers
• Provides recommendations with respect to the future research
Chapter 1: Flavonoids: Molecular mechanisms of anti-SARS-CoV-2 activity and their role in COVID-19 management
Priyanka Nagu, Pankaj Sharma, Arun Parashar, Minaxi Sharma, Baskaran Stephen Inbaraj, Vineet Mehta, Kandi Sridhar
Chapter 2: Traditional herbal medicines for COVID-19: The impact of flavonoids
Mohammed Dalli, Salah-eddine Azizi, Nour Elhouda Daoudi, Ali Azghar, Abderrazak Saddari, Ilyass Alami Merrouni, Mohammed Roubi, Elmostapha Benaissa, Yassine Ben Lahlou, Mostafa Elouennass, Adil Maleb
Chapter 3: Flavonoids as potential drugs for combating SARS-CoV-2: Molecular docking studies
Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Celia Andrés Juan, Francisco J. Plou, Eduardo Pérez-Lebeña
Chapter 4: Molecular aspects on anti-SARS-CoV-2 activity of flavonols: Inhibitory on protein targets, immunomodulatory, and anti-inflammatory effects
Piyush Kashyap, Mamta Thakur, Rhythm Kalsi, Kandi Sridhar, Minaxi Sharma, Shiv Kumar, Baskaran Stephen Inbaraj
Chapter 5: A comprehensive on flavonoids targeting RNA-dependent RNA polymerase of SARS-CoV-2
Anand Kumar Pandey, Shalja Verma
Chapter 6: Flavonols and their derivatives: pioneer natural compounds as potential antiviral drugs against COVID-19
Nermeen Yosri, Heba Alshater, Maria Daglia, Alessandro Di Minno, Shaden A.M. Khalifa, Chao Zhao, Ming Du, Hamud A. Altaleb, Zisheng Luo, Xiaobo Zou, Zhiming Guo, Hesham R. El-Seedi
Chapter 7: Anti-SARS-CoV-2 activity of flavonols and their glycosylated derivatives
Salar Hafez Ghoran, Fatemeh Taktaz, Pouya Alipour, Mojtaba Ghobadi, Seyedeh Elham Faghih-Shirazi, Alireza Zali, Seyed Abdulmajid Ayatollahi
Chapter 8: Isoflavonoids as bioactive molecules against SARS-CoV-2
S Jayashree, K Sonia, G Mayakkannan, S Shruthi, S Aruna Sharmili, Sekar Vijayakumar
Chapter 9: Anti-SARS-CoV-2 activity of flavones: Molecular mechanisms and its role in COVID-19 management
Arun Bahadur Gurung, Atanu Bhattacharjee
Chapter 10: Anti-SARS-CoV-2 activity of chalcones and their synthetic derivatives
Salar Hafez Ghoran, Fatemeh Taktaz, Pouya Alipour, Farah Khameis Farag Teia, Pascal D. Douanla, Amna Hamad Abdallah Atia
Chapter 11: Plant-derived polyphenols in modulating the immune response against COVID-19
Amaresh Mishra, Km Shivangi, Manju Yadav, Dolly Sharma, Jyoti Upadhyay, Yamini Pathak, Vishwas Tripathi
Chapter 12: Molecular insights into anti-SARS-CoV-2 activity of catechins against protein targets for COVID-19 management
Naina Rajak, Vipendra Kumar Singh, Neha Garg
Chapter 13: Role of quercetin in managing COVID-19
Lin Ang, Yixian Quah, Eunhye Song
Chapter 14: Molecular aspects in pharmacological actions of quercetin targeting life cycle of SARS-CoV-2
R. Manikandan, B. Balamuralikrishnan, P. Gajalakshmi, T. Karpagam, A. Shanmugapriya, M. Abirami, R. Ramya, A. Vijaya Anand
Chapter 15: Preventive and therapeutic potentials of epigallocatechin gallate for the management of COVID-19: A mechanistic insight
Shivani Rana, Chetna Jhagta, Arun Parashar, Minaxi Sharma, Baskaran Stephen Inbaraj, Vineet Mehta, Kandi Sridhar
Chapter 16: Anti-SARS-CoV-2 catechins and their roles in COVID-19 management
Puja Gupta, Deepak Nandi, Sonu Ram, Eswar Rao Tatta, Ranjith Kumavath
Chapter 17: Green tea catechins against SARS-CoV-2
Niusha Esmaealzadeh, Roodabeh Bahramsoltani, Roja Rahimi
Chapter 18: Antiviral activities of naringenin and its derivatives as adjuvant treatment against SARS-CoV-2 infections
Pallab Chakraborty, Krishnendu Acharya, Joy Sarkar, Solomon Habtemariam, Javad Sharifi-Rad, William C. Cho
Chapter 19: Luteolin and chrysin as inhibitors of SARS-CoV-2 infection
Keenau Pearce, Burtram Fielding
Chapter 20: Flavonoids: Inhibitors at Stages of Infection by SARS-CoV-2
Jothi Dheivasikamani Abidharini, Ayyadurai Pavithra, Arthi Boro, Palanisamy Sampathkumar, Ramalingam Sivakumar, Saravanan Renuka, Gunna Sureshbabu Suruthi, Arumugam Vijaya Anand
Chapter 21: Traditional medicines and functional foods in Indochina for COVID-19 management: The impact of flavonoids
Sora Yasri, Viroj Wiwanitkit
Biography
Jen-Tsung Chen is a professor of cell biology at the National University of Kaohsiung in Taiwan. He also teaches genomics, proteomics, plant physiology, and plant biotechnology. Dr. Chen’s research interests include bioactive compounds, chromatography techniques, plant molecular biology, plant biotechnology, bioinformatics, and systems pharmacology. He is an active editor of academic books and international journals to advance the exploration of multidisciplinary knowledge involving plant physiology, plant biotechnology, nanotechnology, materials science, ethnopharmacology, and systems biology. He serves as an associate editor, editorial board member, and guest editor in reputed journals. Dr. Chen published books in collaboration with international publishers and he is handling book projects on diverse topics such as drug discovery, herbal medicine, medicinal biotechnology, nanotechnology, bioengineering, plant functional genomics, plant speed breeding, epigenetics, functional RNAs, and CRISPR-based plant genome editing. Dr. Chen is a productive author in academic publications and has been included in the World's Top 2% Scientists 2023 by Stanford University.
