Antiangiogenic Cancer Therapy: 1st Edition (Paperback) book cover

Antiangiogenic Cancer Therapy

1st Edition

Edited by Darren W. Davis, Roy S. Herbst, James L. Abbruzzese

CRC Press

864 pages

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Paperback: 9780367388812
pub: 2019-12-20
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pub: 2007-07-25
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Top Investigators Explore the Complexities of Angiogenesis Cancer Research

The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bevacizumab, the first FDA approved angiogenesis inhibitor, with cytotoxic regimens has led to survival benefits in cancer patients. This has raised important questions about the complexities inherent in the clinical application of angiogenesis inhibitors.

Compiles the results of four decades of progress

Integrating fundamental concepts with therapeutic strategies, Anti-Angiogenic Cancer Therapy promotes the idea that an understanding of the molecular and cellular regulation of angiogenesis leads to optimal therapeutic strategies and positive clinical results. It brings together contributions from leading researchers to provide the most authoritative and encyclopedic volume available on this subject.

  • Examines the role of angiogenesis in cancer, including strategies to prolong the nonangiogenic dormant state of human tumors, molecular mechanisms and cellular regulation of angiogenesis in solid tumors and hematologic malignancies, and the regulation of angiogenesis by the tumor microenvironment.
  • Covers specific molecular targets for inhibiting angiogenesis in cancer therapy.    
  • Discusses clinical trial design and translational research approaches essential for identifying and developing effective angiogenesis inhibitors.
  • Outlines current understanding of the molecular biology of each cancer type followed by discussions that examine strategies for targeting angiogenesis in specific cancers.
  • This volume celebrates progress made in four decades, and more importantly, it provi

    Table of Contents

    Angiogenesis in Cancer; Targeting Angiogenesis for Cancer Therapy; Translating Angiogenesis Inhibitors to the Clinic;  Treatment of Specific Cancers with Angiogenesis Inhibitors

    About the Editors

    Darren W. Davis, Roy S. Herbst, James L. Abbruzzese

    Subject Categories

    BISAC Subject Codes/Headings:
    MEDICAL / Oncology
    MEDICAL / Pharmacology
    SCIENCE / Life Sciences / Cytology
    SCIENCE / Life Sciences / General