Top Investigators Explore the Complexities of Angiogenesis Cancer Research
The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bevacizumab, the first FDA approved angiogenesis inhibitor, with cytotoxic regimens has led to survival benefits in cancer patients. This has raised important questions about the complexities inherent in the clinical application of angiogenesis inhibitors.
Compiles the results of four decades of progress
Integrating fundamental concepts with therapeutic strategies, Anti-Angiogenic Cancer Therapy promotes the idea that an understanding of the molecular and cellular regulation of angiogenesis leads to optimal therapeutic strategies and positive clinical results. It brings together contributions from leading researchers to provide the most authoritative and encyclopedic volume available on this subject.
This volume celebrates progress made in four decades, and more importantly, it provi
Table of Contents
Angiogenesis in Cancer; Targeting Angiogenesis for Cancer Therapy; Translating Angiogenesis Inhibitors to the Clinic; Treatment of Specific Cancers with Angiogenesis Inhibitors
Darren W. Davis, Roy S. Herbst, James L. Abbruzzese