Antimicrobial Pharmacodynamics in Theory and Clinical Practice: 2nd Edition (Paperback) book cover

Antimicrobial Pharmacodynamics in Theory and Clinical Practice

2nd Edition

Edited by Charles H. Nightingale, Paul G. Ambrose, George L. Drusano, Takeo Murakawa

CRC Press

536 pages

Purchasing Options:$ = USD
Paperback: 9780367388966
pub: 2019-09-19
SAVE ~$14.99
$74.95
$59.96
x
Hardback: 9780824729257
pub: 2007-06-15
SAVE ~$46.00
$230.00
$184.00
x
eBook (VitalSource) : 9780429134319
pub: 2007-06-15
from $37.48


FREE Standard Shipping!

Description

Taking readers from the research laboratory to the bedside, this Second Edition compiles essential information on the pharmacodynamics of all major classes of the antimicrobial armamentarium including penicillins, cephalosposorins, cephamycins, carbapenems, monobactams, aminoglycosides, quinolones, macrolides, antifungals, antivirals, and emerging agents currently in development. Written by experienced professionals in the field, this guide uses an abundance of examples to depict methods to apply pharmacodynamic concepts to everyday clinical practice.

Table of Contents

Introduction. Pharmacodynamics of Antimicrobials: General Concepts and Applications Impact of Pharmacodynamics on Breakpoint Selection for Susceptibility Testing. Non-Clinical Models of Infection. In Vitro Antibiotic Pharmacokinetic Models. Animal Models of Infection for the Study of Antibiotic Pharmacodynamics. The Predictive Value of Laboratory Tests for Efficacy of Antibiotic Combination Therapy. Antibacterial Agents. Beta-Lactam Antibiotics. Aminoglycoside Antibiotics. Quinolones. Glycopeptides. Macrolide, Azalide and Ketolides. Metronidazole, and Clindamycin. Streptogramins, Oxazolididones. Tetracyclines. Antiviral Agents. Nucleoside Reverse Transcriptase Inhibitors. Protease Inhibitors. Hepatitis B and C. Antifungal Agents. Amphotericin. Azoles. Gulcan Synthase Inhibitors. Antimalarial Agents. Anti-Malarials. Pharmacodynamics in Drug Development. Human Pharmacodynamics of Anti-Infectives: Determination from Clinical Trial Data. Pharmacodynamics in Global Bridging Studies. Toxicodynamics. Pharmacodynamics and Resistance. Antibacterial Resistance. Application of PK-PD to Clinical and Formulary Decisions. Basic Pharmacoeconomics. Utilizing Pharmacodynamics and Pharmacoeconomics in Clinical and Formulary Decision Making.

About the Editors

Nightingale, Charles H.; Ambrose, Paul G.; Drusano, George L.; Murakawa, Takeo

Subject Categories

BISAC Subject Codes/Headings:
MED022090
MEDICAL / Infectious Diseases
MED072000
MEDICAL / Pharmacy
SCI013000
SCIENCE / Chemistry / General