1st Edition

Antimicrobial/Anti-Infective Materials
Principles and Applications



ISBN 9781566767941
Published December 10, 1999 by CRC Press
346 Pages

USD $350.00

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Book Description

As our consciousness of microbes increases, it appears that our desire to control our interactions with germs also increases in proportion. This is clearly demonstrated by examining the incredible growth in the number and sales volume of consumer products with antimicrobial claims. In the medical field as well, there is much interest in the use of antimicrobial/anti-infective materials for medical devices and general healthcare applications.

Antimicrobial/Anti-Infective Materials: Principles, Applications and Devices represents the best current research and practice on ways to reduce infection caused by devices inserted into the human body. This volume presents important recent developments in the research, development, and applications of anti-infective materials for use in medical devices. It includes 15 in-depth reports by more than 40 leading specialists in biomaterials and medical devices that cover a wide range of important advances in various materials and applications. These include improved coatings and surface modifications techniques, improved materials designed for inherent infection resistance, and applications in the areas of cardiac, orthopedic, ENT, and vascular devices.

This book serves the information needs of all those involved in the research, development, design, and selection of biomaterials and medical devices. It will benefit anyone who designs, uses, and monitors anti-infective materials, as well as those who develop and apply products made from these materials.

Table of Contents

PERSPECTIVES ON INFECTIOUS DISEASE CHALLENGES AND ANTIMICROBIAL ANSWERS
Antimicrobials
Mode of Action and Interaction
Host-Parasite Relationship
Infectious Disease Challenges
Foodborne Diseases and Related Issues
Antimicrobial Drug Resistance and Related Issues
Rational Use of Antimicrobials
Device-Related Infections

INFECTIONS OF INTRACARDIAC DEVICES
Cardiac Pacemakers
Implantable Cardioverter Defibrillators
Left Ventricular Assist Devices
Prosthetic Cardiac Valves

INFECTIONS IN ORTHOPAEDICS
Osteomyelitis: Definition, Classification, and Relationship to Orthopaedic Devices
Etiology and Establishment of Infections on Orthopaedic Devices
Conventional Diagnostic and Treatment Regimens for Osteomyelitis
Alternative Approaches to Infection Treatment and Prophylaxis
Implant Surfaces That Are Passive and/or Anti-Adhesive
Regulatory Issues

PHYSIOCHEMICAL BASIS OF BACTERIAL ADHESION TO BIOMATERIAL SURFACES
Bacterial Adhesion as a Dynamic Process
Properties and Structure of Bacterial Cell Surfaces
Non-Specific Adhesion Mechanisms
Specific Adhesion Mechanisms
Other Factors Affecting Adhesion

ALBUMIN AFFINITY COATINGS MAY PREVENT FOREIGN-BODY INFECTIONS
Foreign-Body Infections
Protein Adsorption
Blood Coagulation
Fibronolysis
Platelet Adhesion
Microbial Adhesion
Medical-Device Coatings

IMMOBILIZED BIOCIDES AS AN ALTERNATIVE STRATEGY FOR CONTROL OF MICROBIAL CONTAMINATION
Synthesis of the Immobilized Peptide Systems
Biological Activity
Chemical and Physical Stability
Discussion and Implications

ANTI-INFECTIVE COATINGS REDUCE DEVICE-RELATED INFECTIONS
Biology on the Surfaces of Indwelling Devices
Anti-Infective Medical Devices by Surface Treatment o Further Research

REDUCED IMPLANT-RELATED INFECTIOUS COMPLICATIONS BY SURFACE MODIFICATION PROVIDING CONTROLLED ANTIMICROBIAL RELEASE
Surface Modification for Controlled Gentamicin Release
Animal Studies-Safety and Efficacy Testing

A CHEMICALLY INTELLIGENT INFECTION-RESISTANT COATING
Anti-Infective Coating Exhibiting Chemical Intelligence
Mechanism of Action
Coating Stability
Bacterial Grow Through Resistance in Coated Microporous Membranes
Efficacy Against Biofilms

MERGING OF BIOMEDICAL AND TEXTILE TECHNOLOGIES IN ORDER TO CREATE INFECTION-RESISTANT PROSTHETIC VASCULAR GRAFTS
Infection of Prosthetic Vascular Grafts
Efforts to Combat Graft Infection
Textile Dyes Versus Antibiotics: Structural and Chemical Similarities
Fluoroquinolone Antibiotics
Interaction of Fibers and Small Molecules
Application of Fluoroquinolones to Polyester via Pad/Heat Dyeing

ASEPTIC APPROACHES AND NOVEL ANTIMICROBIAL CATHETERS FOR PREVENTION OF INFECTION OF VASCULAR CATHETERS
Aseptic Approaches
Novel Anti-Infective Catheters

ANTI-INFECTIVE DEVICES IN OTOLARYNGOLOGY: CURRENT APPLICATIONS AND FUTURE OPPORTUNITIES
Otology: Trans-Tympanic Ventilation Tubes
Present Examples of Anti-Infective Ventilation Tubes
Laryngology: Airway Management Devices and Voice Protheses
Rhinology: Nasal Packing, Sinus Stents, and Nasal Septal Buttons

LABORATORY METHODS FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING: INDICATIONS FOR SUSCEPTIBILITY TESTING
Susceptibility Test Methods
Special Susceptibility Tests
Selection and Reporting of Antimicrobial Agents
Emerging Resistance Problems

TOWARD DOLLAR DEVICES FOR MEASURING METABOLIC BIOCHEMISTRY
A "Simpler" Approach to Bioluminescence-Based Analysis
The ATP Platform
Substrate Specific Sensors
Multi-Analyte Panels
Samples
Other Technologies

SISYPHUS IN THE MICROBIAL WORLD: ANTIMICROBIAL STRATEGIES AND HUMANITY'S HEALTH
Role of Science and Technology in Epidemiological Shifts in Human History
Multidimensional Antimicrobial Strategies: Coping with the Global Threat of Antimicrobial Resistance
Antimicrobial Strategies Through the Lens of the Law
Science, Antimicrobial Strategies, and Future Plagues
Index

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Reviews

This is a book that deserves a place on the bookshelf of any pharmaceutical scientist working on the development of solid dosage forms.
Pharmaceutical Research, vol. 18, no. 9, September 2001