1st Edition

Antitumor Drug Radiation Interactions

Edited By Bridget T. Hill, Angela S. Bellamy Copyright 1990
294 Pages
by CRC Press

294 Pages
by CRC Press

This volume reviews the experimental data on drug-radiation interactions. Special emphasis is placed on clinically-useful antitumor drugs. Particular reference is made to appropriate timing, concentration and sequencing of drug-radiation combinations. It includes discussions on the relative merits of experimental data derived from animal versus human tumors. This book also presents a section on... Read more

Fundamental Concepts Associated with Combining Cytotoxic Drugs and X-Irradiation. Radiation Damage Interaction with Actinomycin D and Adriamycin. Interactions between Bleomycin and X-Irradiation. Interactions between Cyclophosphamide and Radiation. Useful Interactions between 5-Fluorouracil and Radiation in Man: 5-Fluorouracil as a Radio-Sensitizer. Interactions between Microtubule Inhibitors and Ionizing Radiation. Interactions between Mitomycin C and Radiation. Interactions between Nitrosoureas and X-Irradiation. Interactions between Cisplatin and Radiation in Experimental Rodent Tumors and Normal Tissues. Interactions between Platinum Coordination Complexes and Radiation. Experimental Drug-Radiation Interactions in Critical Normal Tissues. In Vitro Drug-Radiation Interactions Using Fractionated X-Irradiation Regimens. Overview of Experimental Investigations of Interactions between Antitumor Drugs and X-Irradiation. Clinical Role of Combined Chemotherapy and Radiotherapy. Overview of Recent Developments and Perspectives.

Biography

Bridget T. Hill, Ph.D., is Head of the Cellular Chemotherapy Laboratory at the Imperial Cancer Research Fund Laboratories in London, England and is an Honorary Senior Lecturer at the Institute of Urology, University College and Middlesex School of Medicine of University College London.

Angela S. Bellamy, M. A.(Cantab.), Ph.D., is now the Product Development Manager for Gower Medical Publishing, London, England.