Ap4A and Other Dinucleoside Polyphosphates is the first compilation of contributions from major investigators involved in studying the chemistry and biology of dinucleoside polyphosphates. The book features reviews and original research (including unpublished and anecdotal material) covering the whole area of dinucleoside polyphosphate research from its inception to the present day. Ap4A and Other Dinucleoside Polyphosphates will be a useful reference for biological scientists studying nucleotide metabolism, cell signalling, DNA replication and repair, and cellular response to stress.
Preface. Dinucleoside Polyphosphates-An Introduction (McLennan and Zamecnik). The Chemistry of Dinucleoside Polyphosphates (Holler). Determination of Dinucleoside Polyphosphates (Garrison and Barnes). Synthesis of NpnN' (n=3 or 4) In Vitro and In Vivo (Plateau and Blanquet). Enzymes Cleaving Dinucleoside Polyphosphates (Guranowski and A. Sillero). Intracellular Functions of ApnN: Prokaryotes (Kitzler, Farr, and Ames). Intracellular Functions of ApnN: Eukaryotes (Remy). Interactions of Dinucleoside Polyphosphates With Enzymes and Other Proteins (M.A.G. Sillero and Cameselle). Extracellular Functions for ApnA (Ogilvie). Diguanosine and Related Non-Adenylylated Polyphosphates (Warner). Synthetic Structural Analogues of Dinucleoside Polyphosphates (Blackburn, McLennan, and Guo).