Applying Pharmacogenomics in Therapeutics

Concepts in Pharmacogenomics and Personalized Medicine
Kelly C. Lee, Joseph D. Ma, and Grace M. Kuo

Principles of Pharmacogenetic Biotechnology and Testing in Clinical Practice
Rui Liu, Gary Yuan Gao, and Long Ma

Essential Pharmacogenomic Biomarkers in Clinical Practice
Cong Liu, Weiguo Chen, and Wei Zhang

Applying Pharmacogenomics in Drug Discovery and Development
Ruth Vinall

Pharmacogenomics and Laboratory Medicine
Jianbo J. Song

Clinical Applications of Pharmacogenomics in Cancer Therapy
Mario Listiawan, Max Feng, and Xiaodong Feng

Clinical Applications of Pharmacogenomics in Drug Therapy of Cardiovascular Diseases
Tibebe Woldemariam

Clinical Applications of Pharmacogenomics in Drug Therapy of Neurologic and Psychiatric Disorders
Megan J. Ehret

Applying Pharmacogenomics in the Therapeutics of Pulmonary Diseases
Wei Zhang and Jason X.-J. Yuan

Pharmacogenomics and Alternative Medicine: Merge of Future and Tradition
Wei Zhang, Xiao-Ping Chen, and Hong-Hao Zhou

Pharmacoeconogenomics: A Good Marriage of Pharmacoeconomics and Pharmacogenomics
Hong-Guang Xie

Biography

Xiaodong Feng, PhD, PharmD, began his biomedical research career 19 years ago in the Wound Healing Center, Stony Brook School of Medicine, Stony Brook, New York, USA. He then served for four years as assistant professor in the Department of Dermatology at the State University of New York at Stony Brook, USA. Currently, Dr. Feng is professor of Pharmacology and Oncology, and Associate Dean at California Northstate University College of Medicine, Elk Grove, USA; clinical pharmacist at Sutter Davis Hospital, California, USA; and oncology pharmacy specialist at Dignity Health Medical Foundation, Rancho Cordova, California, USA.

Hong-Guang Xie, MD, PhD, earned his degrees from Central South University Xiangya School of Medicine, Changsha, China, was promoted to lecturer, and then to associate professor of pharmacology. Subsequently, he served as co-founder and associate director of the Pharmacogenetics Research Institute, Changsha, China; postdoctoral research fellow and faculty research instructor at Vanderbilt University, Nashville, Tennessee, USA; staff research fellow at the University of California Washington Center, DC, USA; and Oak Ridge Institute for Science and Education (ORISE) fellow for the United States Food and Drug Administration (US FDA). Dr. Xie is currently full professor of pharmacology and chief of the General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, China.

The book exemplifies clinical cases of genetic variants in several diseases, defining genetic determinants for drug response and thoroughly describes the applications and therapy in clinical practice. Finally, the authors connect pharmacogenomics with the generation of cost-effectiveness treatments.

Applying Pharmacogenomics in Therapeutics is intended for graduate, medical school courses. or healthcare professionals with a deep focus on genomics, pharmacy, pharmacology, and clinical care practice. Healthcare providers and research scientists would benefit from this text as a reference tool of the recent advances in this field. This text is well written and provides useful examples, tables and clinical cases to better understand and practice the concepts being described. Each chapter begins with a short list of key concepts, an introduction to the topic of the chapter, and concludes with a summary and study questions to practice. The book facilitates an extensive number of references per chapter to educate in depth and to provide tools to increase research and knowledge to the readers. Overall, this text is a comprehensive presentation of the recent approaches in personalized therapy based on genome sequencing and pharmacology combination.

- Judit Jimenez-Sainz, The Yale Journal of Biology and Medicine, vol. 90, March 2017