Applying Pharmacogenomics in Therapeutics  book cover
1st Edition

Applying Pharmacogenomics in Therapeutics

ISBN 9781466582675
Published January 27, 2016 by CRC Press
312 Pages 4 Color & 18 B/W Illustrations

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Book Description

Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a critical requirement. There is an unprecedented urgency for aspiring and practicing clinicians to become trained on how to interpret data from pharmacogenomic testing in preparation for the future of healthcare—i.e., personalized medicine.

Applying Pharmacogenomics in Therapeutics provides timely coverage of the principles, practice, and potential of pharmacogenomics and personalized medicine. Comprised of chapters contributed by well-established pharmacologists and scientists from US and Chinese academia and industry, this authoritative text:

  • Demonstrates how to apply the principles of pharmacogenomics and its biotechnologies in patient care
  • Depicts the use of genetic biomarkers in drug discovery and development, laboratory medicine, and clinical services
  • Describes the practice of pharmacogenomics in the treatment of cancers, cardiovascular diseases, neurologic and psychiatric disorders, and pulmonary diseases
  • Discusses the merging of pharmacogenomics and alternative medicine, as well as the integration of pharmacogenomics into pharmacoeconomics

Each chapter begins with the key concepts, followed by in-depth explorations of case reports or critical evaluations of genetic variants/biomarkers, and concludes with questions for self-examination.

Table of Contents

Concepts in Pharmacogenomics and Personalized Medicine
Kelly C. Lee, Joseph D. Ma, and Grace M. Kuo

Principles of Pharmacogenetic Biotechnology and Testing in Clinical Practice
Rui Liu, Gary Yuan Gao, and Long Ma

Essential Pharmacogenomic Biomarkers in Clinical Practice
Cong Liu, Weiguo Chen, and Wei Zhang

Applying Pharmacogenomics in Drug Discovery and Development
Ruth Vinall

Pharmacogenomics and Laboratory Medicine
Jianbo J. Song

Clinical Applications of Pharmacogenomics in Cancer Therapy
Mario Listiawan, Max Feng, and Xiaodong Feng

Clinical Applications of Pharmacogenomics in Drug Therapy of Cardiovascular Diseases
Tibebe Woldemariam

Clinical Applications of Pharmacogenomics in Drug Therapy of Neurologic and Psychiatric Disorders
Megan J. Ehret

Applying Pharmacogenomics in the Therapeutics of Pulmonary Diseases
Wei Zhang and Jason X.-J. Yuan

Pharmacogenomics and Alternative Medicine: Merge of Future and Tradition
Wei Zhang, Xiao-Ping Chen, and Hong-Hao Zhou

Pharmacoeconogenomics: A Good Marriage of Pharmacoeconomics and Pharmacogenomics
Hong-Guang Xie

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Xiaodong Feng, PhD, PharmD, began his biomedical research career 19 years ago in the Wound Healing Center, Stony Brook School of Medicine, Stony Brook, New York, USA. He then served for four years as assistant professor in the Department of Dermatology at the State University of New York at Stony Brook, USA. Currently, Dr. Feng is professor of Pharmacology and Oncology, and Associate Dean at California Northstate University College of Medicine, Elk Grove, USA; clinical pharmacist at Sutter Davis Hospital, California, USA; and oncology pharmacy specialist at Dignity Health Medical Foundation, Rancho Cordova, California, USA.

Hong-Guang Xie, MD, PhD, earned his degrees from Central South University Xiangya School of Medicine, Changsha, China, was promoted to lecturer, and then to associate professor of pharmacology. Subsequently, he served as co-founder and associate director of the Pharmacogenetics Research Institute, Changsha, China; postdoctoral research fellow and faculty research instructor at Vanderbilt University, Nashville, Tennessee, USA; staff research fellow at the University of California Washington Center, DC, USA; and Oak Ridge Institute for Science and Education (ORISE) fellow for the United States Food and Drug Administration (US FDA). Dr. Xie is currently full professor of pharmacology and chief of the General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, China.


The book exemplifies clinical cases of genetic variants in several diseases, defining genetic determinants for drug response and thoroughly describes the applications and therapy in clinical practice. Finally, the authors connect pharmacogenomics with the generation of cost-effectiveness treatments.

Applying Pharmacogenomics in Therapeutics is intended for graduate, medical school courses. or healthcare professionals with a deep focus on genomics, pharmacy, pharmacology, and clinical care practice. Healthcare providers and research scientists would benefit from this text as a reference tool of the recent advances in this field. This text is well written and provides useful examples, tables and clinical cases to better understand and practice the concepts being described. Each chapter begins with a short list of key concepts, an introduction to the topic of the chapter, and concludes with a summary and study questions to practice. The book facilitates an extensive number of references per chapter to educate in depth and to provide tools to increase research and knowledge to the readers. Overall, this text is a comprehensive presentation of the recent approaches in personalized therapy based on genome sequencing and pharmacology combination.

- Judit Jimenez-Sainz, The Yale Journal of Biology and Medicine, vol. 90, March 2017