1st Edition

Aptasensors for Point-of-Care Diagnostics Fundamentals and Biomedical Applications

Edited By Arpana Parihar, Raju Khan Copyright 2024
    322 Pages 65 B/W Illustrations
    by CRC Press

    The design and fabrication of aptamer-based biosensors for point-of-care testing of disease diagnostic and prognostic is an upthrust and interdisciplinary area of research. This book covers the design and development of novel cost-effective aptamer-based biosensors for disease diagnostic and prognostic including an understanding of health care management in terms of timely updates of disease situations in a particular geographical area. It also discusses the scaling up and market trend of aptamer-based devices for extension of research from lab to market, and end users.


    • Explains the design and fabrication of aptasensors-based diagnostic devices
    • Includes novel approaches and comprehensive technology overview for diagnosis management towards early-stage detection of various biomarkers associated with several health conditions
    • Demonstrates possible benefits of combined diagnostics and therapeutic possibilities using aptamer-based point-of-care technologies devices
    • Discusses emerging implications and recent advances of biosensing platforms for designing and developing aptamer-based point-of-care testing (POCT) devices
    • Explores aptamer-based approach to develop advanced platforms for medical applications and open arena for state-of-the-art future research

    This book is aimed at researchers and graduate students in biomedical engineering, diagnostics, nanobiotechnology, and materials science.

    1. Overview of aptamer-based biosensors

    Datta Maroti Pawde and Sankha Bhattacharya

    2. Biomarkers for aptamer-based diagnostic applications

    Sangeeta Ballav, Veda Joshi, Swarangi Tambat, Urwashi Kumar, Shine Devarajan, Soumya Basu, and Jyotirmoi Aich

    3. Designing and synthesis of aptamer via various approaches (SELEX and ExSELEX)

    Arpana Parihar, Kritika Gaur, Ayushi Singhal and Raju Khan

    4. A comparative study of aptasensor versus immunosensor for biomarker detection

    Priya Chauhan, Annu Pandey, Ayushi Singhal and Raju Khan

    5. Aptamer-based point-of-care diagnostic devices for infectious diseases

    Kalpesh V. Bhavsar, Hardik S. Churi, and Uday P. Jagtap

    6. Aptamer-based colorimetric biosensor

    Yasmin Bano and Sadhana Chaturvedi

    7. Aptamer beacon probes for the detection and visualization of miRNA

    Jayavigneeswari Suresh Babu, Sailaja V. Eluchuri, and Janakiraman Narayanan

    8. Microfluidics-enabled aptamer-based sensing devices – the aptafluidics microdevices

    Vishal K. Sahu, Amit Ranjan, A.S.M. Shailaja, Jyotirmoi Aich, and Soumya Basu

    9. Fabrication of aptamer-based electrochemical biosensor for health care monitoring

    Ayushi Singhal, Apoorva Shrivastava, Arpana Parihar, and Raju Khan

    10. Challenges and advances in aptamer-based biosensing approaches

    Srikanth Ponnada, Sarita Yadav, Demudu Babu Gorle, Meghali Devi, Anjali Palariya, Rapaka S. Chandra Bose, Rakesh K. Sharma

    11. Current perspectives of aptasensors as diagnostic tools for oncological diseases

    Suman Kumar Ray and Sukhes Mukherjee


    Arpana Parihar is currently working as a Women Scientist B at CSIR- AMPRI, Bhopal, MP, India, under the scheme of DST-WoS-B awarded from the Department of Science and Technology, Government of India.

    Raju Khan is currently working as a Principal Scientist and Associate Professor at CSIR-AMPRI Bhopal, Madhya Pradesh, India. He has more than 15 years of experience in electrochemistry, and development of biosensors-based diagnostics.