356 pages | 16 Color Illus. | 47 B/W Illus.
Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology. The studies have also shown aquaporins as potential drug targets and targets for improving crop properties.
Written by an international group of contributors at the forefront of the field, Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery presents the latest research advances in aquaporins and other major intrinsic protein (MIP) channels. The first section of the book describes the general concepts of aquaporin channel function, genomic research, structure-function analysis of aquaporins and glycerol facilitators, and regulation by gating and trafficking, including yeast aquaporin regulation and function. The second section discusses the physiological and pathophysiological roles of aquaporins in humans and microbes. The final section covers the development of inhibitors of aquaporin function. The book’s epilogue offers future perspectives and directions, mainly in the area of aquaporin-based diagnostics and therapeutics.
Stimulating future research on this important protein family, this book facilitates a paradigm shift in the understanding and roles of aquaporin membrane proteins in all biological settings. It encourages scientists to develop novel approaches for the treatment of human diseases based on aquaporin function or dysfunction.
Søren Nielsen and Peter Agre
MECHANISMS OF FLUID TRANSPORT IN CELLS AND EPITHELIA
Aquaporin Functional Detection: Basic Concepts on Water and Solute Permeation
Ana Madeira, Teresa F. Moura, and Graça Soveral
Aquaporin Discovery in the Genomic Era
Rafael Zardoya, Iker Irisarri, and Federico Abascal
Aquaporin Structure and Selectivity
Ardeschir Vahedi-Faridi and Andreas Engel
Regulation of Eukaryotic Aquaporins
Maria Nyblom and Susanna Törnroth-Horsefield
Yeast Aquaporins and Aquaglyceroporins: A Matter of Lifestyle
Mikael Andersson and Stefan Hohmann
AQUAPORINS IN HEALTH AND DISEASE
Aquaporins in Health
Amaia Rodríguez, Leire Méndez-Giménez, and Gema Frühbeck
Renal Aquaporins: Role in Water Balance Disorders
Tae-Hwan Kwon and Søren Nielsen
Vasopressin and the Regulation of Aquaporin-2 in Health and Disease
Giovanna Valenti and Grazia Tamma
Hepatobiliary, Salivary Glands and Pancreatic Aquaporins in Health and Disease
Giuseppe Calamita, Christine Delporte, and Raúl A. Marinelli
Aquaporins within the Central Nervous System: Implications for Oedema Following Traumatic CNS Injury
Anna V. Leonard and Renée J. Turner
Aquaporins in Carcinogenesis: Water and Glycerol Channels as New Potential Drug Targets
Chulso Moon and David Moon
Attacking Aquaporin Water and Solute Channels of Human-Pathogenic Parasites: New Routes for Treatment?
Julia von Bülow and Eric Beitz
AQUAPORINS AS DRUG TARGETS
Aquaporins: Chemical Inhibition by Small Molecules
Vincent J. Huber, Sören Wacker, and Michael Rützler
Drug Discovery and Therapeutic Targets for Pharmacological Modulators of Aquaporin Channels
Jinxin V. Pei, Joshua L. Ameliorate, Mohamad Kourghi, Michael L. De Ieso, and Andrea J. Yool
Inorganic Compounds as Aquaporin Substrates or as Potent Inhibitors: A Coordination Chemistry Point of View
Angela Casini and Andreia de Almeida
Angela Casini and Graça Soveral