Aromatic C(sp2)−H Dehydrogenative Coupling Reactions : Heterocycles Synthesis book cover
1st Edition

Aromatic C(sp2)−H Dehydrogenative Coupling Reactions
Heterocycles Synthesis

ISBN 9780367347291
Published November 18, 2019 by CRC Press
324 Pages 100 B/W Illustrations

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Book Description

This comprehensive text covers the research and development trends in the growing field of aromatic C–H dehydrogenative coupling reactions, leading to different types of heterocycles. The author provides answers to how these coupling reactions occur, what kinds of heterocycles are synthesized, and what their advantages are. The palladium-, rhodium-, iridium-, copper-, cobalt-, ruthenium-, and ferric-catalyzed aromatic C(sp2)–H dehydrogenative cross-coupling reactions are described in detail. A useful reference source for researchers and graduates in the field of heterocyclic chemistry and transition-metal-catalyzed dehydrogenative coupling reactions.


  • Comprehensive volume on the synthesis of benzo-heterocycles via aromatic C(sp2)–H bond activation.
  • Heterocycles are of paramount importance to medicinal chemistry and drug discovery.
  • Provides a comprehensive literature survey on the construction of heterocycles.
  • Reaction procedures and mechanistic explanations are included, which will appeal to those in fine chemicals and pharmaceutical companies.

Table of Contents

Chapter 1: Five-Membered N-Heterocycles

Chapter 2: Six- and Higher-Membered N-Heterocycles

Chapter 3: N-Bridged Heterocycles

Chapter 4: Five-Membered O-Heterocycles

Chapter 5: Six- and Seven-Membered O-Heterocycles

Chapter 6: N,O-Heterocycles

Chapter 7: N,S-Heterocycles

Chapter 8: S- and S,O-Heterocycles 

Chapter 9: P-, and Si-Heterocycles

Chapter 10: Natural Products Synthesis


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Prof. Bagher Eftekhari-Sis obtained his PhD from Sharif University of Technology under the supervision of Prof. Mohammed M. Hashemi in 2009 and then joined the Chemistry Department of the University of Maragheh. His research field involves the synthesis of heterocyclic compounds, supported catalysts, and polymeric and nano-materials. He has some reviews in the fields of organic transformations, especially in the heterocycle synthesis trends in the leading chemistry journal Chemical Reviews.