Aromatic C(sp2)−H Dehydrogenative Coupling Reactions: Heterocycles Synthesis, 1st Edition (Hardback) book cover

Aromatic C(sp2)−H Dehydrogenative Coupling Reactions

Heterocycles Synthesis, 1st Edition

By Bagher Eftekhari-Sis

CRC Press

328 pages | 100 B/W Illus.

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Hardback: 9780367347291
pub: 2019-12-10
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Description

This comprehensive text covers the research and development trends in the growing field of aromatic C-H dehydrogenative coupling reactions, leading to different types of heyterocycles. The author provides answers to how this coupling reaction occurs, what kinds of heterocycles are synthesized, and what its advantages are. The palladium, rhodium, iridium, copper, cobalt, ruthenium and ferric catalyzed aromatic C(sp2)-H dehydrogenative cross-coupling reactions are described in detail. A useful reference source for researchers and graduates in the field of heterocyclic chemistry and transition metal catalyzed dehydrogenative coupling reactions.

Features:

  • Comprehensive volume on the synthesis of benzo-heterocycles via aromatic C(sp2)-H bond activation
  • Heterocycles are of paramount importance to medicinal chemistry and drug discovery
  • Provides a comprehensive literature survey on the construction of heterocycles
  • Reaction procedures and mechanistic explanations are included, which will appeal to those in fine chemicals and pharmaceutical companies

Table of Contents

Content

An Introduction

Chapter 1: Five-Membered N-Heterocycles

1.1 Introduction

1.2 Indoles

1.3 Oxindoles

1.4 Spiro-oxindoles

1.5 Isoindoles

1.6 Carbazoles

1.7 Fused Indoles

1.7.1 Pyrido-indoles

1.7.2 Chromeno- and Quinolino-indoles

1.8 Indazoles

1.8.1 1H-Indazoles

1.8.2 2H-Indazoles

1.9 Benzimidazoles

1.10 Benzotriazoles

1.11 Conclusion

Chapter 2: Six and Higher Membered N-Heterocycles

2.1 Introduction

2.2 Quinoline

2.3 Quinolinone

2.4 Isoquinoline

2.5 Isoquinolinone

2.6 Acridine

2.7 Phenanthridine

2.8 Cinnolines and Phthalazine

2.9 Quinazoline

2.10 Phenazine

2.11 Seven-Membered N-Heterocycles

2.11.1 Benzazepine

2.11.2 Dibenzazepine

2.11.3 Benzodiazepine

2.11.4 Benzazocine and Benzazonine

2.12 Conclusion

Chapter 3: N-Bridged Heterocycles

3.1 Introduction

3.2 Five-Membered N-Bridged Heterocycles

3.2.1 Pyrrolo-indoles

3.2.2 Indolo-indole, Isoindolo-indole and Indolo-carbazole

3.2.3 Isoindolo-isoquinoline

3.2.4 Indolizine

3.2.5 Imidazo-indole and Imidazo-isoindole

3.2.6 Imidazo-pyridine

3.2.7 Indazolo-phthalazine

3.3 Six-Membered N-Bridged Heterocycles

3.3.1 Pyrrolo-quinoline and Pyrrolo-isoquinoline

3.3.2 Indolo-quinoline and Indolo-isoquinoline

3.3.3 Isoquinolino-isoquinoline

3.3.4 Pyrazolo-isoquinoline and Pyrazolo-cinnoline

3.3.5 Imidazo-Fused Heterocycles

3.3.6 Pyrimido-indole

3.3.7 Pyrido-quinazoline

3.3.8 Isoquinolino-quinazoline and Quinazolino-phenanthridine

3.3.9 Cationic Six-Membered N-Bridged Heterocycles

3.4 Seven-Membered N-Bridged Heterocycles

3.5 Conclusion

Chapter 4: Five Membered O-Heterocycles

4.1 Introduction

4.2 Dihydrobenzofurans

4.3 Spiro-dihydrobenzofurans

4.4 Benzofurans

4.5 Dibenzofurans

4.6 Benzofurochromens

4.7 Thienobenzofurans

4.8 Isobenzofurans

4.9 Conclusion

Chapter 5: Six and Seven Membered O-Heterocycles

5.1 Introduction

5.2 Chromene

5.3 Coumarin

5.4 Isochromene

5.5 Isocoumarine

5.6 Heterocycles Fused Coumarine and Isocoumarine

5.7 Benzo[c]chromene

5.8 Benzo[c]chromen-6-one

5.9 Benzo[de]chromene

5.10 Xanthen and Xanthen-9-one

5.11 Seven Membered O-Heterocycles

5.12 Conclusion

Chapter 6: N,O-Heterocycles

6.1 Introduction

6.2 Banzoxazole

6.3 Benzo[1,3]oxazine

6.4 Benzo[1,2]oxazepine

6.5 Dibenzooxazepine

6.6 Conclusion

Chapter 7: N,S-Heterocycles

7.1 Introduction

7.2 Benzoisothiazoles

7.3 Benzothiazoles

7.4 Benzo[4,5]isothiazolo[2,3-a]indoles

7.5 Benzothiazines

7.6 Dibenzo[c,e][1,2]thiazines

7.7 Benzothiadiazines

7.8 Benzothiazepines

7.9 Dibenzothiazepines

7.10 Benzothiazocines

7.11 Conclusion

Chapter 8: S- and S,O-Heterocycles

8.1 Introduction

8.2 Five Membered S-Heterocycles

8.2.1 Benzo[b]thiophene

8.2.2 Dibenzo[b,d]thiophene

8.2.3 Fused Thiophenes

8.3 Six Membered S- and Se-Heterocycles 6

8.3.1 Thiochroman

8.3.2 Benzo[c]thiochromene

8.3.3 Thioxanthene and Thioxanthene-9-one

8.3.4 Selenoxanthones

8.4 Seven Membered S-Heterocycles

8.5 S,O-Heterocycles

8.6 Conclusion

Chapter 9: P-, and Si-Heterocycles

9.1 Introduction

9.2 P-Heterocycles

9.2.1 Phosphindol

9.2.2 Benzophosphindole

9.3 P,O-Heterocycles

9.3.1 Benzo[1,2]oxaphosphole

9.3.2 Benzo[1,2]oxaphosphinine

9.3.3 Dibenzo[1,2]oxaphosphinine

9.4 P,N-Heterocycles

9.4.1 Benzo[1,2]azaphosphinine

9.4.2 Dibenzo[1,2]azaphosphinine

9.5 Si-Heterocycles

9.5.1 Benzosilole and Benzosiline

9.5.2 Dibenzosilole

9.5.3 Tribenzo[b,d,f]silepine

9.6 Si,O-Heterocycles

9.7 Conclusion

Chapter 10: Natural products Synthesis

10.1 Introduction

10.2 Nitrogen Heterocycles Containing Natural Products

10.3 Oxygen Heterocycles Containing Natural Products

10.4 Conclusion

About the Author

Prof. Bagher Eftekhari-Sis obtained his Ph.D. from Sharif University of Technology under the supervision of Prof. Mohammed M. Hashemi in 2009 and then joined the Chemistry Department of the University of Maragheh. His research field involves the synthesis of heterocyclic compounds, supported catalyst, polymeric and nano-materials. He has some reviews in the fields of organic transformations, especially in the heterocycles synthesis trends in the leading chemistry journal "CHEMICAL REVIEWS".

Subject Categories

BISAC Subject Codes/Headings:
SCI007000
SCIENCE / Life Sciences / Biochemistry
SCI013000
SCIENCE / Chemistry / General
SCI013040
SCIENCE / Chemistry / Organic