This book summarizes the research that resulted in aspartame's approval as a food additive as well as related topics regarding its function as a potential sweetening agent. It complies specific issues relating to human consumption of aspartame.
Preface
Contributors
History and Background
Discovery of Aspartame - Robert H. Mazur
Sweeteners: An Overall Perspective- George E. Inglett
Metabolism
Absorption of Peptides, Amino Acids and Their Methylated Derivatives- David M. Matthews
Aspartate and Glutamate Metabolism- Lewis D. Stegink
Phenylalanine Metabolism- Alfred E. Harper
Methanol Metabolism and Toxicity- Thomas R. Tephly and Kenneth E McMartin
Aspartame Metabolism in Animals- James A. Oppermann
Tissue Distribution of Orally Administered Isotopically Labeled Aspartame in the Rat- Yoshimasa Matsuzawa and Yuichi O’Hara
Sensory and Dietary Aspects
Projected Aspartme Intake: Daily Investigation of Aspartic Acid. Phenylalanine, and Methanol- Roberta Roak-Foltz and Gilbert A. Leveille
Comparison of Taste Properties of Apartame with Other Sweeteners- Susan S. Schiffman
Aspartame; Implications for the Food Scientist- Barry E. Homler
Role of Sugar and Other Sweeteners in Dental Caries- William H. Bowen
Efficacy of Low-Calorie Sweeteners in Reducing Food Intake: Studies with Aspartame- Katherine P. Porikos and Theodore B. VanItallie
Preclinical Studies
Preclinical Studies of Aspartame in Non-primate Animals- Samuel V. Molinary
Chronic Feeding Studies with Aspartame and Its Diketopiperazine- Hiroyuka Ishii
Artificial Sweeteners and Bladder Cancer: Assessment of Potential Urinary Bladder Carcinogenicity of Aspartame and Its Diketopiperazine Derivative in Mice- George T. Bryan
Aspartame-Induced Neurotoxicity in Infant Mice-Arnold E. Applebaum, Michael W. Finkelstein, Tahia T. Daabees and Lewis D. Stegink
Neuropathology Studies Following Aspartame ingestion by Infant Nonhuman Primates- W. Ann Reynolds, Linda Parsons, and Lewis D. Stegink
Behavioral Testing in Rodents Given Food Additives- Richard E. Butcher and Charles V. Vorhees
Developmental Assessment of Infant Macaques Receiving Dietary Aspartame or Phenylalanine- W Ann Reynolds, Anne F. Bauman, Lewis D. Stregink, L. J. Filer Jr, and Sakkubai Naidu
Effect of Aspartame on the Learning Test Performance of Young Stumptail Macaques- Stephen J. Suomi
Aspartame and Brain Tumors: Pathology Issues- Adalbert Koestner
Aspartame and Brain Tumors: Statistical Issues- Richard G. Cornell, Robert A. Wolfe, and Paul G. Sanders
Possible Neurihormonal Effects of Aspartame Investigation- Frank M. Sturtevant
Studies of Aspartame Metabolism in Humans
Chronic Ingestion of Aspartame in Humans- Williard J Visek
Aspartame Metabolism in Humans: Acute Dosing Studies- Lewis D. Stegink
Aspartame Ingestion During Pregnancy- Roy M. Pitkin
Aspartame Ingestion During Lactation- George L. Baker
Aspartame Ingestion by Phenylketonuric Heterozygous and Homozygous Individual- Richard Koch and Elizabeth J Wenz
Interactions of Aspartame and Glutamate Metabolism- Lewis D. Stegink
Aspartame Use by Persons with Diabetes- David L. Horwitz
Effects of Acute Aspartame Ingestion on Large Neutral Amino Acids and Monoamines in Rat Brain- John D. Fernstrom
Index
