Aspartame: Physiology and Biochemistry, 1st Edition (Hardback) book cover


Physiology and Biochemistry, 1st Edition

By Filer Stegink

CRC Press

670 pages

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Hardback: 9780824772062
pub: 1984-06-13
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This book summarizes the research that resulted in aspartame's approval as a food additive as well as related topics regarding its function as a potential sweetening agent. It complies specific issues relating to human consumption of aspartame.

Table of Contents



History and Background

Discovery of Aspartame - Robert H. Mazur

Sweeteners: An Overall Perspective- George E. Inglett


Absorption of Peptides, Amino Acids and Their Methylated Derivatives- David M. Matthews

Aspartate and Glutamate Metabolism- Lewis D. Stegink

Phenylalanine Metabolism- Alfred E. Harper

Methanol Metabolism and Toxicity- Thomas R. Tephly and Kenneth E McMartin

Aspartame Metabolism in Animals- James A. Oppermann

Tissue Distribution of Orally Administered Isotopically Labeled Aspartame in the Rat- Yoshimasa Matsuzawa and Yuichi O’Hara

Sensory and Dietary Aspects

Projected Aspartme Intake: Daily Investigation of Aspartic Acid. Phenylalanine, and Methanol- Roberta Roak-Foltz and Gilbert A. Leveille

Comparison of Taste Properties of Apartame with Other Sweeteners- Susan S. Schiffman

Aspartame; Implications for the Food Scientist- Barry E. Homler

Role of Sugar and Other Sweeteners in Dental Caries- William H. Bowen

Efficacy of Low-Calorie Sweeteners in Reducing Food Intake: Studies with Aspartame- Katherine P. Porikos and Theodore B. VanItallie

Preclinical Studies

Preclinical Studies of Aspartame in Non-primate Animals- Samuel V. Molinary

Chronic Feeding Studies with Aspartame and Its Diketopiperazine- Hiroyuka Ishii

Artificial Sweeteners and Bladder Cancer: Assessment of Potential Urinary Bladder Carcinogenicity of Aspartame and Its Diketopiperazine Derivative in Mice- George T. Bryan

Aspartame-Induced Neurotoxicity in Infant Mice-Arnold E. Applebaum, Michael W. Finkelstein, Tahia T. Daabees and Lewis D. Stegink

Neuropathology Studies Following Aspartame ingestion by Infant Nonhuman Primates- W. Ann Reynolds, Linda Parsons, and Lewis D. Stegink

Behavioral Testing in Rodents Given Food Additives- Richard E. Butcher and Charles V. Vorhees

Developmental Assessment of Infant Macaques Receiving Dietary Aspartame or Phenylalanine- W Ann Reynolds, Anne F. Bauman, Lewis D. Stregink, L. J. Filer Jr, and Sakkubai Naidu

Effect of Aspartame on the Learning Test Performance of Young Stumptail Macaques- Stephen J. Suomi

Aspartame and Brain Tumors: Pathology Issues- Adalbert Koestner

Aspartame and Brain Tumors: Statistical Issues- Richard G. Cornell, Robert A. Wolfe, and Paul G. Sanders

Possible Neurihormonal Effects of Aspartame Investigation- Frank M. Sturtevant

Studies of Aspartame Metabolism in Humans

Chronic Ingestion of Aspartame in Humans- Williard J Visek

Aspartame Metabolism in Humans: Acute Dosing Studies- Lewis D. Stegink

Aspartame Ingestion During Pregnancy- Roy M. Pitkin

Aspartame Ingestion During Lactation- George L. Baker

Aspartame Ingestion by Phenylketonuric Heterozygous and Homozygous Individual- Richard Koch and Elizabeth J Wenz

Interactions of Aspartame and Glutamate Metabolism- Lewis D. Stegink

Aspartame Use by Persons with Diabetes- David L. Horwitz

Effects of Acute Aspartame Ingestion on Large Neutral Amino Acids and Monoamines in Rat Brain- John D. Fernstrom


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Food Science and Technology

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