1st Edition

Aspartame Physiology and Biochemistry

By Filer Stegink Copyright 1984
    688 Pages
    by CRC Press

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    This book summarizes the research that resulted in aspartame's approval as a food additive as well as related topics regarding its function as a potential sweetening agent. It complies specific issues relating to human consumption of aspartame.

    History and Background
    Discovery of Aspartame - Robert H. Mazur
    Sweeteners: An Overall Perspective- George E. Inglett
    Absorption of Peptides, Amino Acids and Their Methylated Derivatives- David M. Matthews
    Aspartate and Glutamate Metabolism- Lewis D. Stegink
    Phenylalanine Metabolism- Alfred E. Harper
    Methanol Metabolism and Toxicity- Thomas R. Tephly and Kenneth E McMartin
    Aspartame Metabolism in Animals- James A. Oppermann
    Tissue Distribution of Orally Administered Isotopically Labeled Aspartame in the Rat- Yoshimasa Matsuzawa and Yuichi O’Hara
    Sensory and Dietary Aspects
    Projected Aspartme Intake: Daily Investigation of Aspartic Acid. Phenylalanine, and Methanol- Roberta Roak-Foltz and Gilbert A. Leveille
    Comparison of Taste Properties of Apartame with Other Sweeteners- Susan S. Schiffman
    Aspartame; Implications for the Food Scientist- Barry E. Homler
    Role of Sugar and Other Sweeteners in Dental Caries- William H. Bowen
    Efficacy of Low-Calorie Sweeteners in Reducing Food Intake: Studies with Aspartame- Katherine P. Porikos and Theodore B. VanItallie
    Preclinical Studies
    Preclinical Studies of Aspartame in Non-primate Animals- Samuel V. Molinary
    Chronic Feeding Studies with Aspartame and Its Diketopiperazine- Hiroyuka Ishii
    Artificial Sweeteners and Bladder Cancer: Assessment of Potential Urinary Bladder Carcinogenicity of Aspartame and Its Diketopiperazine Derivative in Mice- George T. Bryan
    Aspartame-Induced Neurotoxicity in Infant Mice-Arnold E. Applebaum, Michael W. Finkelstein, Tahia T. Daabees and Lewis D. Stegink
    Neuropathology Studies Following Aspartame ingestion by Infant Nonhuman Primates- W. Ann Reynolds, Linda Parsons, and Lewis D. Stegink
    Behavioral Testing in Rodents Given Food Additives- Richard E. Butcher and Charles V. Vorhees
    Developmental Assessment of Infant Macaques Receiving Dietary Aspartame or Phenylalanine- W Ann Reynolds, Anne F. Bauman, Lewis D. Stregink, L. J. Filer Jr, and Sakkubai Naidu
    Effect of Aspartame on the Learning Test Performance of Young Stumptail Macaques- Stephen J. Suomi
    Aspartame and Brain Tumors: Pathology Issues- Adalbert Koestner
    Aspartame and Brain Tumors: Statistical Issues- Richard G. Cornell, Robert A. Wolfe, and Paul G. Sanders
    Possible Neurihormonal Effects of Aspartame Investigation- Frank M. Sturtevant
    Studies of Aspartame Metabolism in Humans
    Chronic Ingestion of Aspartame in Humans- Williard J Visek
    Aspartame Metabolism in Humans: Acute Dosing Studies- Lewis D. Stegink
    Aspartame Ingestion During Pregnancy- Roy M. Pitkin
    Aspartame Ingestion During Lactation- George L. Baker
    Aspartame Ingestion by Phenylketonuric Heterozygous and Homozygous Individual- Richard Koch and Elizabeth J Wenz
    Interactions of Aspartame and Glutamate Metabolism- Lewis D. Stegink
    Aspartame Use by Persons with Diabetes- David L. Horwitz
    Effects of Acute Aspartame Ingestion on Large Neutral Amino Acids and Monoamines in Rat Brain- John D. Fernstrom