Providing a comprehensive and critical review of basic science and clinical aspects, this two-volume set covers the history, development, and current patterns of world-wide use of aspirin and ibuprofen. The coverage of pharmacokinetics and therapeutic effects highlights the factors affecting absorption, distribution, metabolism, and elimination. The books outline the chemical properties and synthesis of aspirin and its derivatives and considers the safety vesus efficacy issues and the pharmacoepidemiological data of ibuprofen. With the breadth and depth of scientific and clinical data available in one source, this set is the most definitive reference currently available on these drugs.
VOLUME 1: History and Development of the Salicylates. The Industrial History of Analgesics: The Evolution of Analgesics and Antipyretics. Occurrence, Properties and Synthetic Developments of the Salicylates. Pharmacokinetics and Metabolism of the Salicylates. Metabolism and Pharmacokinetics of Ibuprofen. Pharmacokinetics and Metabolism of Paracetamol (Acetaminophen. Pharmacology and Biochemistry of Salicylates and Related Drugs. Side-effects and Toxicology of the Salicylates. Reye's Syndrome and Aspirin. Salicylates in the Treatment of Acute Pain. Acetysalicylic Acid for the Prevention and Treatment of Thromboembolic Diseases. Use of Salicylates in Rheumatic and Related Conditions. Aspirin and NSAIDs in the Prevention of Cancer, Alzheimer’s Disease and other Novel Therapeutic Actions.
VOLUME 2: History and Development of Ibuprofen. The Medicinal Chemistry of Ibuprofen. The Pharmaceutics of Ibuprofen. The Pharmacokinetcs of Ibuprofen in Humans and Animals . Pharmacology and Toxicology of Ibuprofen. Therapeutics of Ibuprofen in Rheumatic and Other Chronic and Painful Diseases. Safety and Efficacy of Non-Prescription (OTC) Ibuprofen. Use of Ibuprofen in Dentistry. Gastrointestinal Adverse Drug Reactions Attributed to Ibuprofen. Renal Effects of Ibuprofen. Adverse Drug Reactions Attributed to Ibuprofen: Effects Other Than Gastrointestinal. Human Toxicity of Ibuprofen.