Reviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin.
Highlighting the historical evolution of the salicylates and the commercial development of aspirin, the book reviews the pharmacokinetics of the salicylates, ibuprofen, and paracetamol as a basis for understanding the biodisposition of these analgesic drugs. Leading specialists discuss the therapeutic role of aspirin in the prevention and treatment of thrombo-embolic diseases, its place along with non-acetylated salicylates in the treatment of rheumatic diseases and plain, and the potential applications for aspirin and related drugs as prophylactics for colon cancer, Alzheimer's disease, and vascular dementia. They also present comparisons with other drugs used to treat pain and inflammation.
With extensive data and literature covering a broad field, this is the definitive reference on the actions and applications of aspirin, salicylates, and related drugs. Physicians, pharmacists, pharmacologists, toxicologists, and chemists will find this resource useful in their daily work. It will also be valuable to pharmaceutical companies and researchers in the development of newer agents and novel applications.
‘Rainsford and co-writers do a superb job in detailing much of these lesser well-known actions of aspirin. The clinical studies with aspirin are presented exceptionally well and in great detail. The references following each chapter are the most comprehensive that I have seen. Parts of this book will find a very wide audience. Clinicians who use aspirin and related drugs should read some of the clinical chapters to see how little they know about the drugs they use. Research workers will find much here of interest, especially those with their heart in the right place who query prevailing dogmas. I would certainly have benefited from this book at the beginning of my research carrier and I would urge any and all PhD students working with anti-inflammatory drugs to dive into relevant chapters.’
– Professor Ingvar Bjarnason, Professor of Digestive Diseases in the Department of Medicine, King’s College London, for Journal of Pharmacy and Pharmacology, Volume 58, Issue 12, Page 1691, December 2006.
History and Development of the Salicylates, K.D. Rainsford
The Industrial History of Analgesics: The Evolution of Analgesics and Antipyretics, J.R. McTavish
Occurrence, Properties and Synthetic Developments of the Salicylates, K.D. Rainsford
Pharmacokinetics and Metabolism of the Salicylates, G.G. Graham, M.S. Roberts, R.O. Day, and K.D. Rainsford
Metabolism and Pharmacokinetics of Ibuprofen, G.G. Graham and K.M. WIlliams
Pharmacokinetics and Metabolism of Paracetamol (Acetaminophen), G.G. Graham and M. Hicks
Pharmacology and Biochemistry of Salicylates and Related Drugs, K.D. Rainsford
Side-effects and Toxicology of the Salicylates, K.D. Rainsford
Reye's Syndrome and Aspirin, J.F.T. Glasgow and S.M. Hall
Salicylates in the Treatment of Acute Pain, K.D. Rainsford
Acetysalicylic Acid for the Prevention and Treatment of Thromboembolic Diseases, K.E. Webert and J.G. Kelton
Use of Salicylates in Rheumatic and Related Conditions, W.W. Buchanan, W.F. Kean, and K.D. Rainsford
Aspirin and NSAIDs in the Prevention of Cancer, Alzheimer's Disease and other Novel Therapeutic Actions, K.D. Rainsford