Selected as an outstanding book in vascular surgery by members of the Society for Vascular Surgery.*
This unique new text describes the current understanding of the etiology and pathogenesis of human atherosclerosis. It also details the methods for quantitating and characterizing both experimental and clinical lesions, and describes the methods for preparing available animal models. Providing an in-depth review of each of these topics, the text organizes the information in one volume for the convenience of the reader.
The text is divided into two sections. First is a description of the cell biology, biochemistry and pharmacology of normal vessels and of atherosclerotic human lesions, with details of the methods to accurately characterize and quantitate the disease. Secondly, it presents a description of the methods for preparing the available experimental animal models, including a discussion of the distribution and pathological characteristics of the lesions. It also includes comparisons of human atherosclerosis and experimental animal models.
Intended to provide a basis for expediting future research in this priority health care area, this text compiles the available information for those who treat patients with atherosclerosis or who are involved in atherosclerosis research. It is of particular interest to students, physicians, and academic and commercial researchers.
Table of Contents
THE HUMAN ATHEROSCLEROTIC LESION. Theory of Atherosclerosis. Epidemiology and Anatomic Distribution of Atherosclerosis in Man. QUANTITATIVE ASSESSMENT OF ARTERIAL WALL COMPONENTS. Contemporary Concepts in Atherosclerosis Pathology. Pathology of the Extracellular Matrix in Atherosclerosis: In-Vivo and In-Vitro Models. Pharmacology of the Arterial Wall. ANIMAL MODELS OF ATHEROSCLEROSIS. Atherosclerosis in Pigeons. The Use of Rodents for the Study of Atherogenesis and Obesity: The Development of Potential Genetic Models. Rabbit Models of Atherosclerosis. Swine Models of Atherosclerosis. Canine Models of Atherosclerosis. Non-Human Primate Atherosclerotic Models. Atherosclerosis and Healing Abnormalities in Clinical and Experimental Vascular Grafts. Research Needs and Future Perspectives. Index. c. 336 pp., 7x10, December 1989, ISBN-0-8493-6357-8.
Rodney A. White, M.D. is Chief of Vascular Surgery, Harbor-UCLA Medical Center, Torrance, California and Associate Professor of Surgery, UCLA School of Medicine. He is certified by the American Board of Surgery with Special Qualifications for General Vascular Surgery and by the American Board of Laser Surgery., Dr. White graduated in 1970 from Syracuse University with a B.S. in Zoology and obtained his M.D. degree (cum laude, Alpha Omega Alpha) in 1974 from the State University of New York, Upstate Medical Center in Syracuse., Dr. White is a member of the American College of Surgeons, Society for Vascular Surgery, International Society for Cardiovascular Surgery-North American Chapter, The Society of University Surgeons, American Heart Association, Society for Critical Care Medicine, Association for Academic Surgery, Western Vascular Society, Academy of Surgical Research, Pacific Coast Surgical Society, Society for Biomaterials, American Society for Artificial Internal Organs, American Society for Laser Medicine and Surgery, American College of Angiology, American Association for the Advancement of Science, and the New York Academy of Sciences., Dr. White's research interests include the development and evaluation of artificial implant materials, and laboratory and clinical investigation in peripheral vascular surgery. He is a co-inventor of the replamineform technology for fabricating microporous biomaterials, including Interpore International's hydroxyapatite and small diameter vascular prostheses. Dr. White's current research interest also include the use of lasers in medicine and surgery, particularly for angioplasty and for blood vessel anastomotic fusion. He is also actively investigating other interventional cardiovascular devices including angioscopy and other angioplasty guidance methods. He is the recipient of research grants from the National Institutes of Health, the American Heart Association and several corporations., Dr. White is the author of appr