4th Edition

Atlas of Differential Diagnosis in Neoplastic Hematopathology

  • Available for pre-order. Item will ship after August 17, 2021
ISBN 9780367637248
August 17, 2021 Forthcoming by CRC Press
752 Pages 5978 Color & 105 B/W Illustrations

USD $280.00

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Book Description

This atlas presents not only the differential diagnosis but also the detailed morphologic, immunophenotypic, and especially genetic characteristics of the majority of hematolymphoid malignancies. An expert hematopathologist here provides a valuable resource to understand, use, or interpret one or more of these diagnostic modalities with confidence. This new edition has a compact format with up-to-date information - especially on genetic aspects - and will be an indispensable reference for all professionals in the specialty. *Provides an unrivalled visual resource for differential diagnosis in neoplastic hematopathology *Enables specialist and trainee oncologists and pathologists alike to understand, use, and interpret diagnostic modalities with confidence *Supplies quick access to information via tables, algorithms, and composite figures

Table of Contents


  1. Blood
    1. Differential diagnosis of most common abnormal blood findings with suspected malignancy
    2. Approach to most urgent hematologic abnormalities

  2. Lymph nodes
    1. Normal structure
    2. Abnormal patterns

  3. Bone marrow
    1. Normal structure and hematopoiesis
    2. Cytomorphology (abnormal features)
    3. Histology (abnormal patterns)
    4. Patterns of involvement by mature B-cell lymphoproliferative disorders
    5. Patterns of involvement by mature T-cell lymphoproliferative disorders

  4. Immunophenotypic markers - differential diagnosis
  5. Flow cytometry
    1. The major role of flow cytometry analysis
    2. Flow cytometry parameters
    3. Flow cytometry of blood and bone marrow (BM) – gating strategy
    4. The identification of clonal B-cell population
    5. Identification of abnormal T-cell populations
    6. Identification of myeloblasts
    7. Identification of B-lymphoblasts
    8. Identification of T-lymphoblasts
    9. Antigen expression during maturation

  6. Immunohistochemistry
  7. Cytogenetics
    1. Deletions and monosomies
    2. Inversions
    3. Isochromosomes
    4. Translocations
    5. Trisomies

  8. Molecular genetics
    1. Fluorescence in situ hybridization (FISH)
    2. Polymerase chain reaction (PCR)
    3. Next-generation sequencing (NGS)
    4. Genetic markers – differential diagnosis

  9. Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and B-cell prolymphocytic leukemia (B-PLL)
  10. Mantle cell lymphoma (MCL)
  11. Nodal marginal zone lymphoma (NMZL)
  12. Follicular lymphoma (FL)
  13. Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM)
  14. Diffuse large B-cell lymphoma and its variants
    1. Diffuse large B-cell lymphoma (DLBCL)
    2. De novo CD5+ diffuse large B-cell lymphoma
    3. Diffuse large B-cell lymphoma in children
    4. T-cell/histiocyte-rich large B-cell lymphoma
    5. Intravascular large B-cell lymphoma (IVLBCL)
    6. Primary diffuse large B-cell lymphoma of bone or BM
    7. Primary diffuse large B-cell lymphoma of the central nervous system (CNS)
    8. Large B-cell lymphoma with IRF4 rearrangement

  15. Hairy cell leukemia (HCL)
  16. High grade B-cell lymphomas (HGBL)
    1. Burkitt lymphoma (BL)
    2. Burkitt-like lymphoma with 11 aberration (BLL-11q)
    3. High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-R, double/triple hit lymphoma)
    4. High-grade B-cell lymphoma, not otherwise specified (HGBL, NOS)

  17. Plasma cell neoplasms
    1. Plasma cell myeloma (PCM)
    2. Plasmacytoma
    3. Monoclonal gammopathy of undetermined significance (MGUS)
    4. Plasma cell leukemia (PCL)

  18. B-cell lymphomas with plasmablastic morphology and/or EBV expression
    1. Plasmablastic lymphoma (PBL)
    2. ALK+ large B-cell lymphoma
    3. EBV+ diffuse large B-cell lymphoma
    4. KSHV/HHV-8 and EBV-associated germinotropic lymphoproliferative disorder
    5. Lymphomatoid granulomatosis (LyG)
    6. Posttransplant lymphoproliferative disorders
    7. Methotrexate-associated lymphoproliferative disorders
    8. EBV+ mucocutaneous ulcer (EMCU)

  19. T-cell prolymphocytic leukemia (T-PLL)
  20. Adult T-cell lymphoma/leukemia (ATLL)
  21. T-LGL leukemia and chronic lymphoproliferative disorder of NK-cells
  22. Peripheral T-cell lymphoma, not otherwise specified (PTCL)
  23. Angioimmunoblastic T-cell lymphoma (AITL)
  24. Anaplastic large cell lymphoma (ALCL)
    1. ALK+ ALCL
    2. ALK- ALCL

  25. Extranodal T/NK-cell lymphoma, nasal type (ENKTL)
  26. Classic Hodgkin lymphoma (HL)
  27. Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL)
  28. Introduction to myeloproliferative neoplasms (MPN)
  29. Chronic myeloid leukemia (CML; BCR-ABL1+)
  30. Polycythemia vera (PV)
  31. Essential thrombocythemia (ET)
  32. Primary myelofibrosis (PMF)
  33. Mastocytosis
  34. Other myeloproliferative neoplasms
  35. Myelodysplastic syndromes (MDS)
  36. Mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPN)
  37. Acute myeloid leukemia – introduction
  38. Acute myeloid leukemia, not otherwise specified (AML, NOS)
    1. AML with minimal differentiation
    2. AML without maturation
    3. AML with maturation
    4. Acute myelomonocytic leukemia (AMML)
    5. Acute monoblastic leukemia
    6. Acute erythroid leukemia (AEL)
    7. Acute megakaryocytic leukemia
    8. Acute panmyelosis with myelofibrosis (APMF)
    9. Acute basophilic leukemia
    10. Extramedullary myeloid tumor (EMT)

  39. AML with recurrent genetic abnormalities
    1. Acute promyelocytic leukemia (APL)
    2. Acute myeloid leukemia with RUNX1-RUNX1T1
    3. Acute myeloid leukemia with CBFB-MYH11
    4. Acute myeloid leukemia with MLLT3-MLL
    5. Acute myeloid leukemia with DEK-NUP214
    6. Acute myeloid leukemia with RPN1-EVI1
    7. AML with NPM1 mutation
    8. AML with CEBPA mutation

  40. B-cell acute lymphoblastic leukemia and lymphoma (B-ALL/LBL)
  41. T-cell acute lymphoblastic leukemia and lymphoma (T-ALL/LBL)
  42. Other hematopoietic tumors
    1. Acute undifferentiated leukemia (AUL)
    2. Mixed phenotype acute leukemia (MPAL)
    3. Blastic plasmacytoid dendritic cell neoplasm (BPDCN)
    4. Composite hematopoietic tumors
    5. Follicular dendritic cell neoplasms
    6. Histiocytic sarcoma
    7. Langerhans cell histiocytosis
    8. Langerhans cell sarcoma
    9. Metastatic tumors to the bone marrow

  43. Body cavities
  44. Gastrointestinal tract
  45. Liver
  46. Lung and mediastinum
  47. Salivary gland
  48. Skin
  49. Spleen
  50. Testis


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Wojciech Gorczyca, MD, PhD, is a noted authority in clinical flow cytometry and hematopathology, based in New York, USA. His many publications include Flow Cytometry in Neoplastic Hematology, Third Edition, and Cytogenetics, FISH and Molecular Testing in Hematologic Malignancies.