This textbook integrates basic research and clinical aspects underlying the most recent results in those malignant diseases where progress is most effective.
Recent evidence shows that higher doses are better in inducing higher cure rates in hematological neoplasias, although myeloblation related to dose intensity can be a limiting factor. The toxicity can now be controlled with autologous marrow and peripheral blood progenitor cell transplantation, used with or without growth factors. The combination of high dose chemoradiotherapy followed by re-infusion of autologous stem cells constitute a dramatic advance in the treatment of refactory and relapse hematological neoplasias.
Table of Contents
Introduction to the Series -- Preface -- Foreword -- 1 Autotransplant Activity 1989-1994 /R.P. Gale, P.A. Rnwlings and J O. Armitage -- 2 Purification and Evaluation of Hematopoietic Stem Cells for Transplantation /T.E. T homas and P.M. Lansdorp -- 3 Cytokine Regulation of Primitive Progenitors in Culture /M.A.S. Moore -- 4 Isolation of both Normal and Leukemic Cells within the Hematopoietic Stem Cell Compartment of Chronic Myelogenous Leukemia Mobilized Peripheral Blood /A.S. Tsukamoto, D. van den Berg, C. Reading,] Tong, L. Murray, A. Carella, F. Frassoni, D. Snyder, G. Herzig, C. Gorin,J LaPorte, R. Negrin, K Blume, I. Cunningham, D. Claxton, A. Deisseroth and R. Hoffman -- 5 Expansion and Clinical Use ofHematopoietic Progenitor Cells in Human Marrow and Peripheral Blood /RJ Tushinski and R. Hoffman -- 6 Theoretical Basis for Autografting /H.M. Prince and A. Keating -- 7 Pattern of Reconstitution and Relapse following Autologous Bone Marrow Transplantation for Chronic Myelogenous Leukemia /A.B. Deisseroth, M. Talpaz, R. Berenson, S. Heimfeld, C. Reading, J Hester, M. Korbling,J Liang, D. Seong, R. Champlin, H. Kantarjian, I. Khouri and S. Giralt -- 8 Harnessing Immune Control of Leukemia in Autografting /R.Foa -- 9 Pharmacology of High-Dose Therapy with Bone Marrow Transplantation /RB. Jones, P. Cagnoni, S.l. Bearman and EJ Shpall -- 10 The Detection of Minimal Residual Disease in Acute Leukemia /L. Foroni, L. Coyle, M.F. Cole Sinclair, JC. Yaxley, JS. Chim and A. V. Hoffbrand -- 11 Marrow Contamination: Detection and Significance /U.M. Gehling, C.H. Hogan, A. Gee, P. Cagnoni, W Franklin, RB. Jones, S.I. Bearman, M. Ross and EJ Shpall -- 12 Marrow Contamination: Pharmacological Treatment /S. Gulati, C. Romero, V. Rizzoli and C. Carlo-Stella -- 13 Marrow Contamination: Immunological Treatment /JG. Gribben -- 14 Hemopoietic Growth Factors and Autografting /G. Molineux and l.K McNiece -- 15 Autologous Graft-versus-Host Disease /RJ Jones and A.D. Hess -- 16 Approaches to Improving the Results of Total Body Irradiation in Marrow Transplantation /F.R. Appelbaum -- 17 Pretransplant Regimens without Total Body Irradiation (TBI) /G.W Santos -- 18 New Pre-transplant Regimens /R.S. Negrin and KG. Blume -- 19 How does Autologous Hemopoietic Cell Transplantation Cure Acute Myeloid Leukemia? /F. Frassoni and NC. Gorin -- 20 Treatment of Acute Lymphoblastic Leukemia (ALL) in Adults: Problems and Pitfalls /D. Hoelzer -- 21 Autologous Stem Cell Transplantation for Acute Lymphoblastic Leukemia in Children /E. Plouvier and P. Herve -- 22 Autologous Bone Marrow Transplantation for Acute Lymphoblastic Leukemia in Adults /JM. Rowe, J.M. Franklin and H.M. Lazarus -- 23 Treatment of Acute Myloid Leukemia: State of the Art /T. Buchner and L. W Hiddemann -- 24 The Present Status of Autologous Bone Marrow Transplantation in Acute Myeloid Leukaemia /A.K Burnett -- 25 Minimal Residual Disease in Leukemia /G. Saglio and F. Lo Coco -- 26 Autografting for Chronic Myelogenous Leukemia: Is there a Role? /JM. Goldman and S.G. O'Brien -- 27 Autografting with Cultured Marrow for the Myeloid Leukemias: The Vancouver Experience /MJ Barnett, H. G. Klingemann, CJ Eaves and A. C. Eaves -- 28 In Vivo Mobilization of Ph1- Negative Peripheral Blood Progenitor Cells and Autografting in Chronic Myelogenous Leukemia: The Genoa Experience /A.M. Carella, F. Chimirri, F. Benvenuto, 0. Figari, E. Lerma, A. Dejana, E. Prencipe, L. Celesti and M. Podesta -- 29 How does Autografting Cure Aggressive Malignant Non-Hodgkin's Lymphoma? /A.K Fielding and A.H. Goldstone -- 30 The Role of Autografting in Low-grade Lymphoma /J M. Vose, P. J Bierman and J O. Armitage -- 31 Autologous Stem Cell Transplantation in Intermediate and High Grade Lymphoma /C. Gissellnecht and B. Coiffier -- 32 Autografting for Lymphoblastic Lymphoma /J W Sweetenham -- 33 High Dose Therapy (HDT) in Burkitt's Lymphoma /D. Frappaz, J Y. Blay, E. Bouffet, M. Brunat-Mentigny and T. Philip -- 34 Autografting for Hodgkin's Disease /D.L. Longo -- 35 The Role of Intensive Therapy and Autotransplantation for Hodgkin's Disease Patients in an Initial Complete or Partial Remission /D.E. Reece -- 36 Autologous Transplants for Multiple Myeloma /B. Barlogj,e, S. Jagannath, D.H. Vesole, N. Munshi, D. Siegel and G. Tricot -- 37 Autografting in Breast Cancer /JA. Ledermann and A.L. Jones -- 38 High Dose Chemotherapy with Stem Cell Support for Miscellaneous Solid Tumors /B.D. Cheson -- 39 High-Dose Therapy followed by Bone Marrow Rescue in Pediatric Solid Tumors /O. Hartmann and D. Valteau-Couanet -- 40 Autografting with Blood Stem Cell in Hematological Neoplasias: Review of Indications /Ph. Henon -- 41 Umbilical Cord Biology and Transplant /E. Gluckman -- 42 Immunotherapy by Allogeneic Lymphocytes and Cytokines following Autologous and Allogeneic Bone Marrow Stem Cell Transplantation /S. Slavin, E. Naparstek, A. Nagler, A. Ackerstein, G. Varadi, J Kapelushnik and R. Or -- 43 Immune Ablation Followed by Stem Cell Transplantation (Allogeneic) or Support (Autologous) for Severe Autoimmune Diseases Progress, Controversies and Suggested Guidelines /A.M. Marmont -- Index.
Angelo Carella is the Coordinator of the Hematology and ABMT Section at Ospedale S. Martino, Genoa, Italy. A prolific contributor to the literature on hematology, particularly in the leukemias and lymphomas, his publications include six requested chapters in books and over 200 research and clinical articles.