Axoplasmic transport is the intracellular movement of cellular components required for the maintenance and normal physiological functioning of neuronal cells. This book provides an up to date reference for both established investigators as well as for those entering in the field.This volume describes the history and methods of the study of transport and the involvement of energy, ions, calmodulin, microtubules and other cellular components in transport. It also discusses the transport of polypeptides, lipids, nucleic acids, neutrotransmitter containing components and various other particles in nerve fibres. A significant portion of this book is devoted to axoplasmic transport, regeneration and the relevance of transport in neurotropic functions are described in the alst four chapters, followed by a discussion on the mechanism of axoplasmic transport.
1. A Brief Historical Introduction to Axoplasmic transport 2. Analytical Techniques for the Study of Axoplasmic Transport 3. Prelude to Fast Axonal Transport- Sequence of Events in the Cell Body 4. Calmodulin and Its Role in Axoplasmic Transport 6. Metabolic and Ionic Properties of Axoplasmic Transport in Relation to its Mechanism 7. Intra-Axonal Transport of Cytoskeletal Proteins 8. Nucleic Acid Transport 9. Axonal Transport of Glycoproteins and Proteoglycans 10. Particle Movements in Axoplasmic Transport 11. Axonal Transport of Neutrotransmitter Organelles in Adrenergic, Cholinergic, and Peptidergic Neurons 12. Axonal Transport in Nerve and Muscle Diseases 13. Axonal Transport in Experimental Diabetes and Other Models of Metabolic and Toxic Neuropathies 14. Axoplasmic Transport of Neuropeptides in Pathological Systems 15. Chemical Neurotoxins and Disruption of the Axonal Transport System 16. The Relevance of Axoplasmic Transport in Neurotrophic Functions 17. Regeneration Studies in Relation to Transport 18. Retrograde Transport and Regeneration Studies 19. The Destination and Modification of Fast-Transported Proteins in Normal and Regrowing Nerve 20. The Mechanism of Axoplasmic Transport