Bacterial Endotoxic Lipopolysaccharides provides an up-to-date, two-volume review of the latest information regarding bacterial lipopolysaccharide structure and activities. These volumes cover the biochemistry, pharmacology, and pathophysiologic properties of endotoxins. The volumes also thoroughly discuss the strengths and weaknesses of new therapies for septic shock that are based on an immunological attack on endotoxins and the cytokines induced by endotoxins. All scientists involved in endotoxin research, clinical infectious disease specialists, and medical students interested in the pathogenesis of septic shock will find Bacterial Endotoxic Lipopolysaccharides invaluable as a reference resource.
Table of Contents
Biochemistry of Endotoxins: Molecular Biochemistry of Lipopolysaccharides (E.T.. Rietschel, L. Brade, B. Lindner, and U. Zähringer). Chemical Structure of Lipid A (K. Takayama and N. Qureshi). Biosynthesis of Lipid A (C.R.H. Raetz). Chemical Synthesis of Lipid A (S. Kusumoto). Structure-Function Relationships of Lipid A (H. Takada and S. Kotani). Chemical Structure of the Core Region of Lipopolysaccharides (O. Holst and H. Brade). Chemical Synthesis of Core Structures (P.L. Stutz and F.M. Unger). Structure-Function Relationship to Core Oligosaccharide (J.-M. Cavaillon and N. Haeffner-Cavaillon). Supramolecular Structure of Lipopolysaccharides and Lipid A (U. Seydel and K. Brandenburg). Cell Biology of Endotoxin: Cellular Membrane Receptors for Lipopolysaccharide (M.-G. Lei and T.-Y. Chen). Plasma Membrane Gangliosides as Potential Binding Sites for Bacterial Endotoxins (H.C. Yohe, L.S. Brown, and J.L. Ryan). LPS-Initiated Signal Transduction Pathways in Macrophages (D.O. Adams). The LPS Mutational Defect in C3H/HeJ Mice (M. Nakano and H. Shinomiya). Interaction of Liposome-Incorporated Lipopolysaccharide with Responsive Cells (J. Dijkstra and J.L. Ryan). Endotoxin-Endothelial Cell Interactions (T.H. Pohlman and J.M. Harlan). Regulation of Cell Surface Receptor Expression by LPS (A. Ding and C. Nathan). LPS Binding Proteins in Granulocyte Lysosomes (N. Ohno). Processing of LPS by Phagocytes (A.L. Erwin and R.S. Munford). Index.