Prostate brachytherapy (transperineal interstitial implantation of the prostate with either permanent or temporary radioactive sources) has evolved into a sophisticated and definitive treatment modality, used either as monotherapy or in combination with external beam radiation therapy for the treatment of prostate cancer. This popular form of therapy is frequently integrated with neoadjuvant and/or concurrent androgen suppression therapy in the intermediate and advanced risk patient. This book covers both basic and advanced techniques for prostate brachytherapy and is appropriate for the practitioner who is anticipating or currently performing permanent radioactive seed implants. A partial list of topics includes: patient selection, equipment decisions, treatment planning, operative technique, post-implant evaluation, management of acute/long term treatment and follow-up after implant. The accompanying CD-ROM, with video clips, is an invaluable teaching tool. Basic and Advanced Techniques in Prostate Brachytherapy is for practitioners of prostate brachytherapy-urologists, radiation oncologists, medical oncologists and medical physicists.
Table of Contents
Introduction. Ultrasound Principles and Anatomy of the Prostate. Effect of Radiology on Prostate Histopathology and Assessment of Residual Cancer. What Should You Ask Your Pathologist When Contemplating Minimally Invasive Therapy. Detailed Mapping of Prostate Carcinoma Foci: Implications for Prostate Brachytherapy. Treatment Decisions: Surgery vs. Brachytherapy: A Urologist's Perspective. Treatment Decisions: a Patient's Perspective on Prostate Brachytherapy. Principles of Prostate Brachytherapy Isotope Decisions. Use of Artificial Neural Networks in the Clinical Staging of Prostate Cancer: Implications for Prostate Brachytherapy. What Do Whole Mount Radical Prostatectomy Specimens Teach Us About Extracapsular Disease. Implications for Prostate Brachytherapy. Can Permanent Implants Address Extracapsular Disease, Can Extraprostatic Extension be Treated by Prostate Brachytherapy? An Analysis Based on Postimplant Dosimetry. Evaluating the Role of Neoadjuvant Deprivation for Patients Undergoing Prostate Brachytherapy. Impact of Hormonal Therapy on Pubic Arch Interference. Pre Implantation Urologic Considerations. Selection of Equipment for Prostate Brachytherapy. Advances Beyond Biplanar Ultrasound for Permanent Prostate Implants. What to Look for When Choosing Treatment Planning Software for Prostate Brachytherapy. A Comprehensive Review of Prostate Cancer Brachytherapy: Defining an Optimal Technique. Planning an Implant: Preplanning Versus Intraoperative Planning. Point Kernels and Superposition Methods for Scatter Dose Calculations in Brachytherapy. Treatment Planning for High Dose-rate Prostate Brachytherapy. High Dose-rate Afterloading Iridium-192 Prostate Brachytherapy. Use of Conformal High-dose Rate Brachytherapy for Management of Patients with Prostate Cancer: Optimizing Dose Escalation. The Role of High Dose Rate Prostate Brachytherapy in the Management of Prostate Cancer, Treatment Planning and Results from Memorial Sloan-Kettering Cancer Center. Modified Uniform Seed Loading for Prostate Brachytherapy: Rationale, Design and Evaluation. Treatment Planning and the Seattle Prostate Institute Approach to Treatment Planning for Permanent Implants. Surgical Tips: Improving Ultrasound Imaging During Interstitial Implant. Intraoperative Technique. Intraoperative Technique Using Pd-103. Intraoperative Technique with Biplane Ultrasound and Fluoroscopic Guidance for Optimal Seed Placement. Performing a Prostate Implant Under Local Anesthesia. A Prospective Multi-center Study of Transperineal Prostatic Block for Transurethral Needle Ablation (TUNA) of the Prostate. Improvement of Transperineal Implant Dosimetry by Intraoperative Cystoscopic Confirmation of Prostate Anatomy Nursing Management of Prostate Brachytherapy Patients. Management of Patients Receiving Transperineal Palladium-103 Prostate Implants. Prevention of Perineal Hematoma Using the Perineal Pressure Application Device (PPAD) After Prostate Brachytherapy. The Role of a Needle Manipulator/ruler in 1125/Pd 103 Preloaded Needle Implants of the Prostate. Defining a Quality Prostate Implant. Options for a Suboptimal Permanent Prostate Implant. Long-term Results. Radiation Oncologist's Perspective. Biochemical Outcome After Radical Prostatectomy, External Beam Radiotherapy or 125I Prostate Brachytherapy for Low and Intermediate Risk Prostate Cancer Patients. Acute and Chronic Toxicity After IMRT/HDR for Patients S/P TURP, Large Glands, High IPS Scores: Patient Selection, OR Technique, Treatment Planning, Inpatient Management, Catheter Movement and QOL Assessment Long-term Results. A Urologist's Perspective. The Intermediate Risk Disease Patient: Is There an Advantage for External Beam Radiotherapy and Implant? Experimental Evaluation of the Rtog Recommendation for Permanent Prostate Brachytherapy Implants. Dosimetric Analysis of Urinary Morbidity Following Prostate Brachytherapy (125i vs. 103pd) Combined with External Beam Radiation Therapy. Lessons from the Learning Curve Erectile Function Following Prostate Brachytherapy. Rectal Complications after Permanent Seed Implants Sexual Dysfunction after Permanent Implant. Management of Voiding Dysfunction Following Implantation. Transient Elevation of Serum Prostate.
'This book deserves a place in the reference library of every urological department.' - Professor Stephen Langley, BJU International 2005