Basics of Molecular Recognition: 1st Edition (Hardback) book cover

Basics of Molecular Recognition

1st Edition

By Dipankar Chatterji

CRC Press

125 pages | 20 Color Illus. | 104 B/W Illus.

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pub: 2016-04-13
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Description

Basics of Molecular Recognition explores fundamental recognition principles between monomers or macromolecules that lead to diverse biological functions. Based on the author’s longtime courses, the book helps readers understand the structural aspects of macromolecular recognition and stimulates further research on whether molecules similar to DNA or protein can be synthesized chemically.

The book begins with the types of bonds that participate in the recognition and the functional groups that are capable of forming these bonds. It then explains how smaller molecules select their partners in the overall recognition scheme, offering examples of specific recognition patterns involving molecules other than nucleic acids. The core of the book focuses on macromolecular recognition—the central dogma of molecular biology. The author discusses various methods for studying molecular recognition. He also describes how molecules without biological functions can be arrayed or folded following certain rules and examines the nature of interactions among them.

Molecular recognition is a vast area encompassing every aspect of biology. This book highlights all aspects of non-covalent macromolecular recognition processes, including DNA–protein recognition and sugar–protein recognition.

Table of Contents

Features of Interacting Monomers with Different Functionalities: What Drives the Binding?

FUNCTIONAL GROUPS IN RECOGNITION BETWEEN SMALL MOLECULES

MOLECULES WITH DIFFERENT FUNCTIONALITIES

CONFIGURATION AND CHIRALITY

LOCK-AND-KEY AND INDUCED FIT MODEL

NONCOVALENT INTERACTIONS

Molecular Recognition among Various Monomers

CROWN ETHER–METAL ION RECOGNITION

PEPTIDE–ANTIBIOTIC RECOGNITION

DRUG–RECEPTOR INTERACTION

SUGAR–PROTEIN RECOGNITION

CELL WALL COMPOSITION AND SUGARS

CELL–CELL COMMUNICATION AND SMALL MOLECULE–RECEPTOR RECOGNITION

LECTIN–SUGAR RECOGNITION

Macromolecular Recognition

STATIC AND DYNAMIC MOLECULAR RECOGNITION

DIFFERENCE BETWEEN CHEMICAL AND BIOLOGICAL MACROMOLECULES

BIOLOGICAL MACROMOLECULES

POLYMERIZATION OF NUCLEIC ACIDS

MOLECULAR RECOGNITION AT THE HEART OF THE CENTRAL DOGMA OF MOLECULAR BIOLOGY

POLYMERIZATION OF BIOLOGICAL MONOMERS

HORMONES AND RECEPTORS

ANTIGEN–ANTIBODY RECOGNITION

BLOOD GROUPING

Methods to Follow Molecular Recognition

SIZE-EXCLUSION CHROMATOGRAPHY

SURFACE PLASMON RESONANCE

AFFINITY CHROMATOGRAPHY

ION-EXCHANGE CHROMATOGRAPHY

HYDROPHOBICITY

SPECTROSCOPIC TOOLS THAT UTILIZE MOLECULAR RECOGNITION

ISOTHERMAL TITRATION CALORIMETRY

Macromolecular Assembly and Recognition with Chemical Entities

FOLDING AND MOLECULAR RECOGNITION

HOST–GUEST RECOGNITION AND SUPRAMOLECULAR ASSEMBLY

MOLECULAR INFORMATION PROCESSING AND SELF-ORGANIZATION

RECOGNITION BETWEEN METAL IONS AND NUCLEIC ACIDS

Suggested Readings

Index

About the Author

Dipankar Chatterji is a professor in the Molecular Biophysics Unit at the Indian Institute of Science, Bangalore. Dr. Chatterji was the president of the Indian Academy of Sciences from 2013 to 2015. His major area of research focuses on the regulation of gene expression in bacteria under stress, including important pathways such as stringent response and quorum sensing.

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
SCI008000
SCIENCE / Life Sciences / Biology / General
SCI055000
SCIENCE / Physics