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Beyond Nature and Nurture in Psychiatry: Genes, Environment and their Interplay book cover

1st Edition

Beyond Nature and Nurture in Psychiatry Genes, Environment and their Interplay

Edited By James MacCabe, Owen O'Daly, Robin Murray, Peter McGuffin, Pádraig Wright Copyright 2006
240 Pages
by CRC Press

For much of the last century, the so-called nature-nuture debate polarised opinion about the aetiology of mental illness. But the extreme biological or environmental positions adopted in the past are not supported by the recent evidence. Based on lectures presented as part of the third European Foundation for Psychiatry at the Maudsley (EFPM) meeting, this book will show that genes and environment... Read more
Foreword by James D Watson * Preface * Section I. The study of gene–environment interplay * 1. The most stupendous era in the history of psychiatry? * 2. Types of gene–environment interplay and their statistical properties * 3. The myth of the heritability index * Section II. Cognitive ability and disability through the lifespan * 4. Do heavier babies make brighter children? * 5. Gene–environment interactions and correlations in the development of cognitive abilities and disabilities * 6. Cognitive function and impairment in elderly twins * Section III. Childhood and development *  7. Genetic regulation of complex social behaviour in a monogamous rodent * 8. Childhood adversity, monoamine oxidase A genotype and risk for conduct disorder * 9. Genetics and environment in ADHD * Section IV. Affective disorders * 10. Genetics of bipolar disorder * 11. Stressful life events, 5-HTT genotype and risk of depression * 12. Genetic variation in 5-HT signalling, amygdala reactivity and susceptibility for affective disorders * 13. Adolescent depression: is cortisol vulnerability genetic? * Section V. Psychosis: Now that we have some genes * 14. Genes for schizophrenia and beyond * 15. Genes, hypoxia and schizophrenia * 16. Genes, cannabis and psychosis * Section VI. Addictions * 17. Genetic epidemiology of alcohol dependence: the Collaborative study On the Genetics of Alcoholism * 18. Imaging vulnerability factors in addiction with PET and [11C]raclopride * Section VII. Did God forget to read DSM-IV? 19. Did God forget to read DSM? Genes are not diagnosis-specific * 20. Are the genetic and environmental factors impacting on schizophrenia and bipolar disorder the same or different? * 21. Genotype–environment interaction – sometimes there, sometimes not

Biography

James MacCabe is MRC Special Training Fellow in Health of the Public Research, Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom.

Owen O’Daly is PhD Student at the Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom.

Robin Murray is Professor of Psychiatry and Head of the Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom.

Peter McGuffin is Professor of Psychiatric Genetics and Director of the MRC Social, Genetic and Developmental Psychiatry Centre at the Department of Psychiatry, Institute of Psychiatry, London, United Kingdom.

Padraig Wright is Honorary Consultant, Department of Psychiatry, Institute of Psychiatry, London, UK.

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