Big Data in Radiation Oncology gives readers an in-depth look into how big data is having an impact on the clinical care of cancer patients. While basic principles and key analytical and processing techniques are introduced in the early chapters, the rest of the book turns to clinical applications, in particular for cancer registries, informatics, radiomics, radiogenomics, patient safety and quality of care, patient-reported outcomes, comparative effectiveness, treatment planning, and clinical decision-making. More features of the book are:
- Offers the first focused treatment of the role of big data in the clinic and its impact on radiation therapy.
- Covers applications in cancer registry, radiomics, patient safety, quality of care, treatment planning, decision making, and other key areas.
- Discusses the fundamental principles and techniques for processing and analysis of big data.
- Address the use of big data in cancer prevention, detection, prognosis, and management.
- Provides practical guidance on implementation for clinicians and other stakeholders.
Dr. Jun Deng is a professor at the Department of Therapeutic Radiology of Yale University School of Medicine and an ABR board certified medical physicist at Yale-New Haven Hospital. He has received numerous honors and awards such as Fellow of Institute of Physics in 2004, AAPM Medical Physics Travel Grant in 2008, ASTRO IGRT Symposium Travel Grant in 2009, AAPM-IPEM Medical Physics Travel Grant in 2011, and Fellow of AAPM in 2013.
Lei Xing, Ph.D., is the Jacob Haimson Professor of Medical Physics and Director of Medical Physics Division of Radiation Oncology Department at Stanford University. His research has been focused on inverse treatment planning, tomographic image reconstruction, CT, optical and PET imaging instrumentations, image guided interventions, nanomedicine, and applications of molecular imaging in radiation oncology. Dr. Xing is on the editorial boards of a number of journals in radiation physics and medical imaging, and is recipient of numerous awards, including the American Cancer Society Research Scholar Award, The Whitaker Foundation Grant Award, and a Max Planck Institute Fellowship.
Table of Contents
1 Big Data in Radiation Oncology: Opportunities and Challenges
2 Data Standardization and Informatics in Radiation Oncology
3 Storage and Databases for Big Data
Tomas Skripcak, Uwe Just, Ida Schönfeld, Esther G.C. Troost, and Mechthild Krause
4 Machine Learning for Radiation Oncology
Yi Luo & Issam El Naqa
5 Cloud Computing for Big Data
Sepideh Almasi and Guillem Pratx
6 Big Data Statistical Methods for Radiation Oncology
Yu Jiang, Vojtech Huser, Shuangge Ma
7 From Model-Driven to Knowledge and Data-Based Treatment Planning
Morteza Mardania, Yong Yanga, Yinyi Yeb, and Stephen Boyd, and Lei Xinga
8 Using Big Data to Improve Safety and Quality in Radiation Oncology
Eric Ford, PhD, Alan Kalet, PhD, Mark Phillips
9 Tracking Organ Doses for Patient Safety in Radiation Therapy
Wazir Muhammad, Ying Liang, Gregory R. Hart, Bradley Nartowt, David A. Roffman, Jun Deng
10 Big Data and Comparative Effectiveness Research in Radiation Oncology
Sunil W. Dutta; Daniel M. Trifiletti; Timothy N. Showalter
11 Cancer Registry and Big Data Exchange
Zhenwei Shi, Leonard Wee, and Andre Dekker
12 Clinical and Cultural Challenges of Big Data in Radiation Oncology
Brandon Dyer, Shyam Rao, Yi Rong, Chris Sherman, Mildred Cho, Cort Buchholz, and Stanley Benedict
Barry S. Rosensteina, Gaurav Pandey, Corey W. Speersc, Jung Hun Ohd, Catharine M.L. Weste and Charles S. Mayoc
14 Radiomics and Quantitative Imaging
Dennis Mackin, PhD and Laurence E. Court, PhD
15 Radiotherapy Outcomes Modeling in the Big Data Era
Joseph O. Deasy, PhD, Aditya P. Apte, PhD, Maria Thor, PhD, Jeho Jeong, PhD, Aditi Iyer, MS, Jung Hun Oh, PhD, and Andrew Jackson
16 Multi-parameterized Models for Early Cancer Detection and Prevention Gregory R. Hart, David A. Roffman, Ying Liang, Bradley Nartowt, Wazir Muhammad, Jun Deng