Microelectromechanical systems (MEMS) are evolving into highly integrated technologies for a variety of application areas. Add the biological dimension to the mix and a host of new problems and issues arise that require a broad understanding of aspects from basic, materials, and medical sciences in addition to engineering. Collecting the efforts of renowned leaders in each of these fields, BioMEMS: Technologies and Applications presents the first wide-reaching survey of the design and application of MEMS technologies for use in biological and medical areas.
This book considers both the unique characteristics of biological samples and the challenges of microscale engineering. Divided into three main sections, it first examines fabrication technologies using non-silicon processes, which use materials that are appropriate for medical/biological analyses. These include UV lithography, LIGA, nanoimprinting, injection molding, and hot-embossing. Attention then shifts to microfluidic components and sensing technologies for sample preparation, delivery, and analysis. The final section outlines various applications and systems at the leading edge of BioMEMS technology in a variety of areas such as genomics, drug delivery, and proteomics.
Laying a cross-disciplinary foundation for further development, BioMEMS: Technologies and Applications provides engineers with an understanding of the biological challenges and biological scientists with an understanding of the engineering challenges of this burgeoning technology.
Table of Contents
Introduction; Wanjun Wang and Steven A. Soper
BASIC BIO-MEMS FABRICATION TECHNOLOGIES
UV Lithography of Ultra-Thick SU-8 for Microfabrication of High-Aspect-Ratio Microstructures and Applications in Microfluidic and Optical Components; Ren Yang and Wanjun Wang
The LIGA Process: A Fabrication Process for High-Aspect-Ratio Microstructures in Polymers, Metals, and Ceramics; Jost Goettert
Nanoimprinting Technology for Biological Applications; Sunggook Park and Helmut Schift
Hot Embossing for Lab-on-a-Chip Applications; Ian Papautsky
MICROFLUIDIC DEVICES AND COMPONENTS FOR BIO-MEMS
Micropump Applications in Bio-MEMS; Jeffrey D. Zahn
Micromixers; D.E. Nikitopoulos and A. Maha
Microfabricated Devices for Sample Extraction, Concentrations, and Related Sample Processing Technologies; Gang Chen and Yuehe Lin
Bio-MEMS Devices in Cell Manipulation: Microflow Cytometry and Applications; Choongho Yu and Li Shi
BIO-MEMS APPLICATIONS AND SYSTEMS
Coupling Electrochemical Detection with Microchip Capillary Electrophoresis; Carlos D. García and Charles S. Henry
Culture-Based Biochip for Rapid Detection of Environmental Mycobacteria; Ian Papautsky and Daniel Oerther
MEMS for Drug Delivery; Kabseog Kim and Jeong-Bong (J-B.) Lee
Microchip Capillary Electrophoresis Systems for DNA Analysis; Ryan T. Kelly and Adam T. Woolle
Bio-MEMS Devices for Proteomics; Justin S. Mecomber, Wendy D. Dominick, Lianji Jin, and Patrick A. Limbach
Single-Cell and Single-Molecule Analyses Using Microfluidic Devices; Malgorzata. A. Witek, Mateusz L. Hupert, and Steven A. Soper
Pharmaceutical Analysis Using Bio-MEMS; Celeste Frankenfeld and Susan Lunte