Coronaviruses can cause illness, severe disease, and death; for example, Middle East respiratory syndrome (MERS), severe acute respiratory syndrome (SARS), and COVID-19. Vaccine development and antiviral drugs are challenged by the propensity for viral mutations allowing these viruses to evade such therapies. There are a number of bioactive compounds from natural sources, which can exert health benefits and act as antiviral therapies such as anti-inflammation, antioxidative stress, and immune regulation. This book summarizes research on the potential efficacy and underlying mechanisms of bioactive compounds and traditional medicines against SARS-CoV-2.
Key Features
- Summarizes the potential benefits of bioactive therapies for coronaviruses
- Focuses on COVID-19, but also covers MERS and SARS
- Provides alternatives to vaccines and other antiviral drugs whose efficacy is reduced by viral mutations
- Relevant for clinicians and public health officials
Chapter 1 - Omics-guided intervention strategies in combatting SARS-CoV-2: Recent advancements and challenges
Contributors: Somrita Padma, Nabarun Chandra Das, Ritwik Patra, Pritha Chakraborty, Abhijit Dey, Suprabhat Mukherjee
Chapter 2 - The application of computer-aided drug design methods for developing natural compounds-based therapeutics against SARS-CoV-2
Contributors: Priya Godara, Dhaneswar Prusty
Chapter 3 - Therapeutic targets of host factors for potential COVID-19 treatments
Contributors: Sabarinath Neerukonda
Chapter 4 - Phytocompounds: A paradigm shift as therapeutics for COVID-19
Contributors: Vijeta Prakash, Paridhi Bhatia, Shweta Dang, Pammi Gauba, Reema Gabrani
Chapter 5 - Flavonoids as potential therapeutic agents against the SARS-CoV-2 infection: An overview
Contributors: Anand Kumar Pandey, Shalja Verma
Chapter 6 - Antiviral activities of flavonoids against COVID-19 and other virus-causing ailments
Contributors: Arthi Boro, Biju Reji Souparnika, Srinivasan Atchaya, Shanmugam Ramya, Natchiappan Senthilkumar, Shanmugam Velayuthaprabhu, Rengasamy Lakshminarayanan Rengarajan, Arumugam Vijaya Anand
Chapter 7 - Potential therapeutic effects of flavonoids against the COVID-19 infection: The mode of action
Contributors: Aswani R.B, Honey Pavithran , Ranjith Kumavath
Chapter 8 - Terpene and Terpenoid: Potent antiviral agents against SARS-CoV-2
Contributors: Dwaipayan Sinha, Moumita Chatterjee, Srijonee Choudhury, Sanchita Seal, Tapas Das, Shilpi Sharma, Swastika Banerjee, Shahana Chowdhury
Chapter 9 - Phytonutrients and secondary metabolites to cease SARS-CoV-2 loop
Contributors: Ajith Sivasangar Latha, Poornima Prasad Anita, Nihala Sidhic, Elizabeth James, Mohandass Kaviya, Kathirvel Bharathi, Balasubramanian Balamuralikrishna, Arumugam Vijaya Anand
Chapter 10 - Treatment strategies against COVID-19 using bioactive compounds and plant secondary metabolites
Contributors: Syeda Aroosa Mohsin, Humaira Fatima, Rabia Javed
Chapter 11 - The potential contribution of vitamin K as a nutraceutical to scale down the mortality rate of COVID-19
Contributors: Shanmugam Ramya, Arthi Boro, Irudhayaraj Peatrise Geofferina , Arumugam Jananisri , Ganesh Vishalini , Balasubramanian Balamuralikrishnan, Meyyazhagan Arun, Arumugam Vijaya Anand
Chapter 12 - Gastrointestinal Symptoms in COVID-19 patients: Prevention and Treatment
Contributors: Mohamed Bouhrim, Noureddine bencheikh , Nour Elhouda Daoudi , Amine Elbouzidi , Hayat Ouassou , Loubna Kharchoufa , Doha Berraaouan , Jen-Tsung Chen , Christophe Hano, Mohamed Addi , Mostafa Elachouri, Mohamed Bnouham
Chapter 13 - Mechanisms and management options of liver injury in COVID19: A Review
Contributors: Daoudi Nour Elhouda, Bouhrim Mohamed, Bouziane Omar, Mamri Samira, Marghich Mohamed, Ouassou Hayat, Mohamed addi, Christophe Hano, Jen-Tsung Chen, Bnouham Mohamed
Chapter 14 - Marine species-derived bioactives against coronavirus disease
Contributors: Augustus Akshaya Rani, Samsudeen Malik Basha, Syed Saadullah Ashfaq, Roy Apoorva, Jana Sudipta, Shunmugiah Karutha Pandian
Chapter 15 - Potential bioactive compounds of Indian flora against SARS-CoV-2
Contributors: Deepyaman Das, Joydeep Chakraborty, Harshita Shand, Rittick Mondal, Soumita Podder, Suvankar Ghorai, Amit Kumar Mandal
Chapter 16 - Natural product-derived active compounds for the management of COVID-19: A summary from Indochina
Contributors: Sora Yasri; Viroj Wiwanitkit
Chapter 17 - Novel therapeutic strategy based on nanomedicine targeting thrombosis for SARSCoV-2
Contributors: Xingping Quan, Xiaofeng Gong, and Yonghua Zhao
Chapter 18 - Nanomaterials in combating human coronavirus infections
Contributors: Mohanapriya Chelladurai, Renganathan Sahadevan, Sekar Vijayakumar
Chapter 19 - Structural insights into drug targets from MERS, SARS-CoV, and SARS-CoV-2 and scope for phytochemicals as broad-spectrum anti-virals and immunomodulators.
Contributors: Nikhil Singh, Rafiq Mohamed, UV Babu, Raghavendra P Rao, Prachi Singh
Chapter 20 - Precision phytochemicals for COVID-19-induced olfactory dysfunction
Contributors: Sachiko Koyama, Vonnie D.C. Shields, Thomas Heinbockel
Biography
Jen-Tsung Chen is currently a professor at the National University of Kaohsiung in Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. His research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, plant physiology, and plant biotechnology. He has published over 90 scientific papers and serves as an editorial board member for Plant Methods and Plant Nano Biology.
