This comprehensively written text covers, in-depth, all aspects of bioadhesive systems. Bioadhesive systems are presently playing a major role in the field because of their ability to maintain a dosage form at a precise body-site for a prolonged period of time over which the active principle is progressively released. Included in this book are descriptions of the different mucosae in healthy and pathological situations, a theoretical approach of polymers-mucin interactions, and a comparative description of the methods used to evaluate bioadhesion. Up-to-date reviews of pharmaceutical applications are also given - subdivided according to the route of administration and type of system. It also contains a chapter devoted to the fundamentals of bioadhesion. This reference is an indispensable guide for researchers in the pharmaceutical field as well as academic researchers.
Mucus Physiology and Pathology. Scaling Concepts and Molecular Theories of Adhesion of Synthetic Polymers to Glycoproteinic Networks. Test Methods of Bioadhesion. Bioadhesives/Mucoadhesives in Drug Delivery to the Gastrointestinal Tract. Nanoparticles as a Gastroadhesive Drug Delivery System. Mucoadhesive Buccal Patches for Peptide Delivery. Bioadhesive Dosage Forms for Buccal/Gingival Administration. Semisolid Dosage Forms as Buccal Bioadhesives. Bioadhesive Dosage Forms for Nasal Administration. Ocular Bioadhesive Delivery Systems. Nanoparticles as Bioadhesive Ocular Drug Delivery Systems. Bioadhesive Dosage Forms for Vaginal and Intrauterine Applications.