Biocatalysis in the Pharmaceutical and Biotechnology Industries: 1st Edition (Hardback) book cover

Biocatalysis in the Pharmaceutical and Biotechnology Industries

1st Edition

Edited by Ramesh N. Patel

CRC Press

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Description

Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications.

Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening.

Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.

Reviews

“… examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications. The authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction …”

— In Anticancer Research, Vol. 27, No. 3B, May/June 2007

“This mammoth multi-author volume contains 34 chapters on all aspects of biocatalysis …. In fact the volume covers all the major areas one would wish to see in such a tome and contains some excellent reviews of individual topics.

“…I enjoyed the individual chapters and each author has made an attempt to give an idea of the future perspectives in his area. The chapters are extremely well referenced…”

“There is no doubt that this work should be in the libraries of all who have interests in biocatalysis, whether in academia or in industry … [and] provides relatively up-to-date data on a very wide range of topics in a highly readable format. Recommended…”

Organic Process Research and Development, Vol. 11, No. 2, p. 296

Table of Contents

Nitrilases and Nitrile Hydratases; R. DiCosimo

Biocatalytic Deracemization: Dynamic Resolution, Stereoinversion, Enantioconvergent Processes and Cyclic Deracemization; Y.Simeó, W. Kroutil, and K. Faber

A Decade of Biocatalysis at Glaxo Wellcome; M. Mahmoudian

Biocatalysis for Synthesis of Chiral Pharmaceutical Intermediates; R.N. Patel

Directed Evolution of Lipases and Esterases for Organic Synthesis; A. Hidalgo and U.T. Bornscheuer

Flavin-Containing Oxidative Biocatalysts; M.W. Fraaije and W.J.H. van Berkel

Preparation of Chiral Pharmaceuticals through Enzymatic Acylation of Alcohols Amines; V. Gotor-Fernández, F. Rebollledo, and V. Gotor

Dynamic Kinetic Resolution and Asymmetric Transformations by Enzyme–Metal Combinations; M.J. Kim, Y. Ahn, and J. Park

Biotransformation of Natural or Synthetic Compounds for the Generation of Molecular Diversity; R. Azerad

Applications of Aromatic Hydrocarbon Dioxygenases; R.E. Parales and S.M. Resnick

A Genomic Approach to Investigating Baker’s Yeast Reductions; J.D. Stewart

Immobilization of Enzymes as Cross-linked Enzyme Aggregates: A Simple Method for Improving Performance; R.A. Sheldon

Biotechnological Applications of Aldolases; W.D. Fessner and S.Jennewein

Enzymatic Synthesis of Modified Nucleosides; L.A. Condezo, J. Fernández-Lucas, C.A. García-Burgos, A.R. Alcántara, and J.V. Sinisterra

Biocatalytic Reduction of Carboxylic Acids: Mechanism and Applications; P. Venkitasubramanian, L. Daniels, and J.P.N. Rosazza

Dehalogenases in Biodegradation and Biocatalysis; D.B. Janssen

Enzymatic Synthesis of Sugar Esters and Oligosaccharides from Renewable Resources; A. Ballesteros, F.J. Plou, M. Alcalde, M. Ferrer, H. García-Arellano, D. Reyes-Duarte, and I. Ghazi

Efficient Methods and Instrumentation for Engineering Custom Enzymes; S.J. Robles, W.J. Coleman, and M.M. Yang

Deaminating Enzymes of the Purine Cycle as Biocatalysts for Chemoenzymatic Synthesis and Transformation of Antiviral Agents Structurally Related to Purine Nucleosides; E. Santaniello, P. Ciuffreda, and L. Alessandrini

Microbial and Enzymatic Processes for the Production of Chiral Compounds; K. Honda, T. Ishige, and S. Shimizu

Discovery of Arylmalonate Decarboxylase and Conversion of the Function by Rational Design; K. Miyamoto and H. Ohta

Chemoenzymatic Preparation of Enantiopure Building Blocks of Synthetic Utility; K. Mori

Stereoselective Modifications of Polyhydroxylated Steroids; E. Fossati and S. Riva

Recent Developments in Enzymatic Acyloin Condensations; O. Ward and A. Singh

Synthesis of Chiral Alcohols with Carbonyl Reductase Library and Robust NAD(P)H Regenerating System; H. Yamamoto and A. Matsuyama

Comparative Analysis of Chemical and Biocatalytic Syntheses of Drug Intermediates; M.J. Homann, W.C. Suen, N. Zhang, and A. Zaks

Industrial Processes Using Lyases for C–C, C–N, and C–O Bond Formation; M. Pohl and A. Liese

State of the Art and Applications in Stereoselective Synthesis of Chiral Cyanohydrins; F. Effenberger, S. Förster, and C. Kobler

Chiral Switches: Problems, Strategies, Opportunities, and Experiences; R. Csuk

Enzyme Evolution for Chemical Process Applications; G.W. Huisman and J.J. Lalonde

Biocatalytic Routes to Nonracemic Chiral Amines; N.J. Turner and R. Carr

Enantioselective Biocatalytic Reduction of Ketones for the Synthesis of Optically Active Alcohols; S. Buchholz and H. Gröger

Enzyme Catalysis in Nonaqueous Media: Past, Present, and Future;

S. Dreyer, J. Lembrecht, J. Schumacher, and U. Kragl

Biocatalytic Concepts for the Synthesis of Optically Active Amines; S. Buchholz and H. Gröger

Index

About the Authors/Editor

Patel\, Ramesh N.

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
SCI010000
SCIENCE / Biotechnology
SCI013000
SCIENCE / Chemistry / General
SCI013060
SCIENCE / Chemistry / Industrial & Technical