Biochemistry: An Organic Chemistry Approach, 1st Edition (Paperback) book cover


An Organic Chemistry Approach, 1st Edition

By Michael B. Smith

CRC Press

372 pages | 1000 Color Illus.

Purchasing Options:$ = USD
Paperback: 9780815366454
pub: 2020-05-19
Available for pre-order. Item will ship after 19th May 2020
Hardback: 9780815367130
pub: 2020-05-19
Available for pre-order. Item will ship after 19th May 2020

FREE Standard Shipping!


Reactions in biochemistry can be explained by an understanding of fundamental organic chemistry principles and reactions. This paradigm is extended to biochemical principles and to myriad biomolecules.

Biochemistry: An Organic Chemistry Approach provides a framework for understanding various topics of biochemistry, including the chemical behavior of biomolecules, enzyme activity, and more. It goes beyond mere memorization. Using several techniques to develop a relational understanding, including homework, this text helps students fully grasp and better correlate the essential organic chemistry concepts with those concepts at the root of biochemistry. The goal is to better understand the fundamental principles of biochemistry.


  • Presents a review chapter of fundamental organic chemistry principles and reactions.
  • Presents and explains the fundamental principles of biochemistry using principles and common reactions of organic chemistry.
  • Discusses enzymes, proteins, fatty acids, lipids, vitamins, hormones, nucleic acids and other biomolecules by comparing and contrasting them with the organic chemistry reactions that constitute the foundation of these classes of biomolecules.
  • Discusses the organic synthesis and reactions of amino acids, carbohydrates, nucleic acids and other biomolecules.

Table of Contents

Chapter 1: Introduction

Chapter 2: Acids and Bases. A Review

Chapter 3: Bonding

Chapter 4: An Introduction to Nomenclature

Chapter 5: Functional Groups Found in Biochemistry Applications

Chapter 6: Acids and Bases in Biochemical Systems

Chapter 7. Chemical Reactions, Bond Energy and Kinetics

Chapter 8: Rotamers and Conformation

Chapter 9: Stereoisomers: Chirality,Enantiomers, and Diastereomers

Chapter 10: Acid-Base Reactions of -Bonds: Addition Reactions

Chapter 11: Nucleophiles: Lewis Base-Like Reactions at sp3 Carbon

Chapter 12. Based-Induced Elimination Reactions

Chapter 14: Spectroscopic Methods of Identification

Chapter 15: Organic Molecules That Contain Alkali Metals or Transition Metals (Organometallics)

Chapter 16: Carbonyl Compounds. Structure, Nomenclature, Reactivity

Chapter 17: Oxidation

Chapter 18: Reactions of Aldehydes and Ketones

Chapter 19: Reduction

Chapter 20: Carboxylic Acid Derivatives and Acyl Substitution

Chapter 21: Aromatic Compounds and Benzene Derivatives

Chapter 22: Enolate Anions: Acyl Addition and Acyl Substitution

Chapter 23: Difunctional Molecules: Dienes and Conjugated Carbonyl Compounds

Chapter 26: Heteroaromatic Compounds

Chapter 27: Multifunctional Compounds: Amino Acids and Peptides

Chapter 28: Multifunctional Compounds: Carbohydrates

Chapter 29: Photochemistry and Photosynthesis

Chapter 30: Hormones

Chapter 31: Antibiotics and Anti Virals

Chapter 32: Anti-Cancer Agents

About the Author

Dr. Michael Smith was born in Detroit, Michigan, and moved to Madison Heights, Virginia in 1957. He graduated from Amherst County High School in 1964 and worked for a year before starting college at Ferrum Jr. College in 1965. He graduated in 1967 with an A.A. and began studies at Virginia Tech later that year, graduating with a B.S. in Chemistry in 1969. He worked as a chemist at the Newport News Shipbuilding & Dry Dock Co, Newport News, Virginia, from 1969 until 1972. In 1972 he began studies at Purdue University in West Lafayette, Indiana, working with Prof. Joseph Wolinsky, and graduated in 1977 with a Ph.D. in Organic Chemistry. He held postdoctoral positions at Arizona State University in Tempe, Arizona, with Professor Bob Pettit and then at MIT in Cambridge, Massachusetts, with Prof. Sidney Hecht. He began his independent career as an assistant professor in the Chemistry department at the University of Connecticut, Storrs, CT, in 1979 and received tenure in 1986. He subsequently spent six months on sabbatical in Belgium, with Prof, Leon Ghosez at the Université Catholique de Louvain in Louvain la Neuve, Belgium. He was promoted to full professor in 1994. His research career involved the synthesis of biologically interesting molecules, which led to more than 95 peer reviewed research articles. Dr. Smith has previously published 26 books, including Organic Chemistry. An Acid-Base Approach, 2nd edition with Taylor&Francis, the 5th-8th editions of March’s Advanced Organic Chemistry with Wiley, and Organic Synthesis, 4th edition (winner of a 2018 Texty award) with Elsevier. Dr. Smith retired from UCONN in January of 2017 and he now holds the rank of Professor Emeritus.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
SCIENCE / Chemistry / General
SCIENCE / Chemistry / Organic
SCIENCE / Chemistry / Physical & Theoretical