Biochemistry of Non-Shivering Thermogenesis in Vertebrates Evolutionary Perspectives

Unit 1:- NONSHIVERING THERMOGENESIS THROUGH BROWN FAT AND ALLIED MECHANISMS

1.      Evolutionary and developmental origin of brown adipose tissue

Sunil Pani and Naresh C Bal

2.      Molecular mechanisms of heat production in brown adipose tissue

Bijayashree Sahu and Naresh C Bal

3.      Neurohormonal regulation of heat production in brown adipose tissue

Anuttama Pal and Naresh C Bal

4.      Thermogenic Determinants in Hibernation Models

Moriah Hunstiger and S. Ryan Oliver

Unit 2:- SKELETAL MUSCLE NONSHIVERING THERMOGENESIS: EVOLUTIONARY, MECHANISTIC AND ECOLOGICAL ASPECTS

5.      Endothermy in Fishes: A Remarkable Story of Convergent Evolutionary Adaptation.

Jens P.C. Franck and Sean Robinson

6.      Whole-body endothermy and non-shivering thermogenesis (nst) in today’s birds and mammals and in their past

Gordon Grigg

7.      Non-shivering thermogenesis in birds: A role for skeletal muscle

Jose Eduardo Pereira Wilken Bicudo, Kênia Cardoso Bicego and Punyadhara Pani

8.      Ryanodine Receptor 1 calcium leak in non-shivering thermogenesis

Aldo Meizoso-Huesca and Bradley S Launikonis

9.      Futile SERCA-mediated calcium cycling activity as the basis for non-shivering thermogenesis in the skeletal muscle

Naresh C. Bal and Muthu Periasamy

10. Recruitment of non-shivering thermogenesis in skeletal muscle: Importance of environmental context

Colleen M Novak and Christina A Watts

Unit 3:- BIOMEDICAL RELEVANCE OF NONSHIVERING THERMOGENESIS

11. Targeting mitochondrial energy efficiency to treat chronic metabolic diseases

Sam D. Houma, Julius L. Larion, Abraham Karim, and Shona Mookerjee

12. Muscle-based thermogenesis and its physiological implications for obesity and muscle health

Bianca M. Marcella, Jessica L. Braun, Mia S. Geromella and Val A. Fajardo

13. Recruitment of brown and beige adipose tissue thermogenesis through muscular activity

Leslie A. Rowland

14. Phytochemicals as potential candidates to combat obesity via non-shivering thermogenesis

Hanbing Li, Yuanhai Sun, Tengjiao Zhao, Sunying Cheng

Biography

Dr. Naresh Chandra Bal

Associate Professor

KIIT School of Biotechnology

Bhubaneswar, Odisha

Dr. Bal has more than 15 years of research experience in muscle and brown adipose tissue (BAT) thermogenesis. He also possesses more than 20 years of teaching experience in physiology and biochemistry related subjects at different levels. He has designed and performed studies on several transgenic mouse models using manipulation of thermogenic capacities of both the sites: BAT and muscle. In addition to these transgenic models he has also employed other strategies such as pharmacological, surgical and diet-intervention to address questions related to thermogenesis, especially non-shivering thermogenesis (NST). Dr. Bal has authored more than 30 manuscripts on this topic including top-tier journals such as Nature Medicine, Trends in Endocrinology and Metabolism, Biological Reviews, Journal of Biological Chemistry (JBC), and Biochemical Journal. He has published 60 journal articles in total and his papers have been cited by top researchers in the field from all over the world. Currently, his H-index is 30 with total citation of more than 3000. For his pioneering research, Dr. Bal has been awarded with several honors including Physiological Genomics Fellowship, American Physiological Society (APS), USA; K01 Award from National Institutes of Health (NIH), USA; Ramalingaswami Re-entry Fellowship, Government of India; and Early Career Research Award, Government of India. He serves as associate editor in Frontiers in Physiology and editor in Metabolites & Molecular Medicine Reports. Due to his scientific contribution he has been elected as the Fellow of the Royal Society of Biology, UK.

Ms. Punyadhara Pani

Senior Research Fellow

KIIT School of Biotechnology

Bhubaneswar, Odisha

Ms. Punyadhara Pani is currently working in the laboratory of Dr. Bal in delineating molecular mechanisms of muscle non-shivering thermogenesis (NST) in birds. She completed her bachelor's degree from Utkal University and master's from Ravenshaw University with Summa-cum-Laude. She served as a teacher and taught undergraduate students for about five years. Due to her excellent academic distinctions, she has been awarded with one of the most competitive pre-doctoral research funding called DST-Inspire Fellowship from the Government of India. She is admirable in writing and has won first prize in several state-level competitions. She designed and developed her manuscripts which have been published in several renowned journals including Biological Reviews, Biochemical Journal, among others. Moreover, Ms. Pani has successfully presented her work in the form of poster and oral presentations in both national and international conferences for which she has received recognition and awards. She has done extensive research on skeletal muscle adaptation to environmental factors, pharmacological agents and cytokines leading to several recent publications in internationally reputed journals. For these studies, she has used different animal models including mammalian and avian providing biochemical/genetic insight for NST in the muscle.