Biodegradable Hydrogels for Drug Delivery  book cover
1st Edition

Biodegradable Hydrogels for Drug Delivery

ISBN 9781566760041
Published May 17, 1993 by CRC Press
262 Pages

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Book Description

From the Authors' Preface
The advances made in the area of controlled drug delivery during the last two decades are remarkable ….Of the many polymeric materials, biodegradable hydrogels present unique advantages and opportunities in the development of …delivery devices….We have undertaken the challenge of putting together information relevant to biodegradable hydrogels in one place. This book covers the mechanisms of biodegradation, types of biodegradable hydrogels,chemical and physical gels, chemical and enzymatic degradation, and examples of biodegradable drug delivery systems.

Table of Contents

Chapters, sub-chapters and selected sub-sections, some condensed for this space. All chapters end with a section of References.
o Controlled Release Drug Delivery Systems
o Hydrogels: Definition, Hydrogel as a Biomaterial, Biodegradable Hydrogels
o Definitions: Bioresorption, Bioabsorption, Bioerosion, Biodeterioration
o Mechanisms: Solubilization, Charge Formation Followed by Dissolution
o Chemical Hydrolysis of Polymers:Enzyme-Catalyzed Hydrolysis
o Biodegradable Hydrogels
Types of Biodegradable Hydrogels
o Hydrogels with Degradable Polymer Backbone: Crosslinked Hydrogels, Noncrosslinked Hydrogels
o Hydrogels with Degradable Crosslinking Agents: Crosslinked with Small Molecules, Crosslinked with Oligopeptides, Crosslinked with Macromolecules
o Hydrogels with Degradable Pendant Chains
Chemical Gels
o Polymerization in the Presence of Crosslinking Agents: Introduction of Double Bonds to Macromolecules, Determination of Double Bonds on the Macromonomers
o Crosslinking of Water-Soluble Polymers: Crosslinking with Functional Groups, Nonspecific Crosslinking, Determination of the Degree of Crosslinking
Physical Gels
o Thermoreversible Gelling System: Gels with Thermomelting Properties,Gels with Thermogelation Properties
o Thermoreversible Gelling Polysaccharides: Water-Soluble Polysaccharides, Gel-Forming Polysaccharides
o Physical Gelation by Ion Complexation: Polymers with Hydroxyl Groups, Carrageenan, Gellan, Pectin, Alginate, Polyphosphazenes, Other Polyanions, Chitosan
o Physical Gelation by Specific Interactions: Fibrin Gel, Mucus Gel, Actin Gel, Avidin-Biotin Mediated Gel, Antibody Mediated Gel, Lectin-Mediated Gel
oDetermination of the Crosslink Density
Chemically-Induced Degradation
o Chemically-Induced Hydrolysis in the Body: Distribution and Elimination, Factors Influencing Chemically-Induced Hydrolysis
o Chemically-Induced Hydrolysis of Polyesters: Poly(glycolic Acid), Poly(lactic Acid), Polycaprolactone, Poly(ethylene Terephthalate), Poly(ß-hydroxybutyrate), Polydioxanone
o Polyester Hydrogels
Enzyme-Catalyzed Degradation
o Properties of Enzymes
o Hydrolytic Enzymes in the Body: Gastrointestinal Tract, Reticuloendothelial System, Others
o Factors Influencing Enzyme-Catalyzed Reactions: Conformation of Enzymes and Substrates, Presence of Polymer Molecules
o Enzyme-Catalyzed Degradation of Modified Proteins: Albumin, Gelatin, Modified Enzymes
o Enzyme-Catalyzed Degradation of Modified Polysaccharides: Dextran, Starch, Amylose, Chitosan, Chondroitin-6-Sulfate
Biodegradable Drug Delivery Systems
o Mechanisms of Drug Release: Diffusion-Controlled Systems, Swelling-Controlled Systems, Biodegradable Systems
o Drug Release From Hydrogels with Biodegradable Backbones: Hydrogels Based on Protein/Polypeptides, Hydrogels Based on Polysaccharides, Biodegradable Hydrogels Based on Polyesters
o Drug Release From Hydrogels with Degradable Crosslinking Agents: Hydrogels Crosslinked with Small Molecules, Hydrogels Crosslinked with Albumin
o Drug Release from Hydrogels with Biodegradable Pendant Chains
Future Development
o Drug Loading
o Drug Targeting
o Drug Release
o Degradation and Elimination
o Use of Bioactive Polymers

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"The book …presents the first comprehensive reference concerned exclusively with this topic. The book provides an easy access to the subject both for those who are just starting to work in the field and for experience professionals. It affords a broad survey of hydrogel synthesis, degradation, and use for drug
-Benedikt T. Haag, Department of Chemistry, Virginia Commonwealth University, in Journal of Bioactive and Compatible Polymers
"This book is an excellent addition to the literature of controlled delivery of bioactive materials. It is well written, edited, and referenced. I would strongly recommend this book to …those in the biotechnology and pharmaceutical industries."
-Tarun K.Mandal,Assistant Professor of Pharmaceutics, Xavier University of Louisiana, in BioPharm