Biodegradable Systems in Tissue Engineering and Regenerative Medicine: 1st Edition (Hardback) book cover

Biodegradable Systems in Tissue Engineering and Regenerative Medicine

1st Edition

Edited by Rui L. Reis, Julio San Román

CRC Press

592 pages | 135 B/W Illus.

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pub: 2004-11-29
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Description

Conventional materials technology has yielded clear improvements in regenerative medicine. Ideally, however, a replacement material should mimic the living tissue mechanically, chemically, biologically and functionally. The use of tissue-engineered products based on novel biodegradable polymeric systems will lead to dramatic improvements in health care.

The most important materials in development for use in tissue engineering, replacement, and regeneration are based on polymers and on composites reinforced with bioactive ceramics. The first book to address the topic in an integrated manner, Biodegradable Systems in Tissue Engineering and Regenerative Medicine presents an extensive description of biodegradable polymers used in medicine and explores their design, development, and processing. The authors discuss the performance of biodegradable systems and the special requirements that should be taken into account when evaluating their biocompatibility. Included are several methodologies for tailoring cell adhesion and proliferation on the surface of biodegradable polymers.

This book represents a coordinated effort by outstanding international experts, and provides an integrated, forward-looking perspective. By joining together the most active groups in the field, the editors offer a unified approach, representing diverse fields of study, to produce a revolution in regenerative medicine.

Reviews

"Written from well-known experts, the book gives a comprehensive overview of all the open and solved problems related to the role played from polymer-based systems in tissue engineering replacement, and regeneration. …it has to be in the library of all the chemical and medical community that has interest or should like to know in a deeper way all the problems linked to this relevant and fascinating topic."

-P. Morganti, Editor-in-Chief, Journal of Applied Cosmetology

Table of Contents

PROCESSING AND APPLICATIONS OF BIODEGRADABLE SYSTEMS

Biodegradable Polymers in Medicine

M. Suzuki and Y. Ikada

Injectable Biodegradable Systems

L. F. Boesel and R. L. Reis

Injectable Polymeric Scaffolds for Bone Tissue Engineering

M.E. Gomes, R.L. Reis, and A.G. Mikos

Totally or Partially Biodegradable Self-Polymerizing Composites for Orthopedic Surgery and Dental Applications

B. Vázquez, G.A. Abraham, C. Elvira, and J. San Román

Fiber Bonding and Particle Aggregation as Promising Methodologies for the Fabrication of Biodegradable Scaffolds for HardTissue Engineering

M.E. Gomes, P.B. Malafaya, and R.L. Reis

Design and Fabrication of Scaffolds Via Solid Free Form Fabrication

D.W. Hutmacher

Biodegradable Composites for Biomedical Applications

N. M. Neves, J. F. Mano, and R.L. Reis

Development of Bioactive Composites Based on Biodegradable Systems for Bone Replacement Applications

B. Leonor, R. A. Sousa, and R.L. Reis

Mechanical Characterization of Biomaterials

J. F. Mano, N. M. Neves, and R.L. Reis

Chitosan-Based Microcomposites - From Biodegradable Microparticles to Self-Curing Hydrogels

A. Gallardo, M.R. Aguilar, C. Elvira, C. Peniche, and J. San Roman

Processing and Biomedical Applications of Degradable Polymeric Fibers

K. Tuzlakoglu and R.L. Reis

Understanding the Enzymatic Degradation of Biodegradable Polymers and Strategies to Control Their Degradation Rate

H.S. Azevedo and R.L. Reis

PRODUCTION OF BIOMIMETIC COATINGS ON THE SURFACE OF DEGRADABLE POLYMERS

Bonelike Apatite Coatings Nucleated on Biodegradable Polymers as a Way to Induce Bone Mineralization: Current Developments and Future Trends

A. L. Oliveira and R.L. Reis

Biomimetic Coatings, Proteins, and Biocatalysts: A New Approach to Tailor the Properties of Biodegradable Polymers

I.B. Leonor, H.S. Azevedo, C.M. Alves, and R.L. Reis

SYSTEMS FOR CONTROLLED RELEASE OF BIOACTIVE AGENTS

Strategies for Delivering Bone and Cartilage Regenerating Factors

P.B. Malafaya, G.A. Silva, and R.L. Reis

Resorbable Polymeric Delivery Systems Based on Physical Absorption/Diffusion versus Chemically Controlled Delivery Systems

J. San Román, A. Gallardo, C. Elvira, B. Vázquez, and G.A. Abraham

Enzyme Immobilization in Biodegradable Polymers for Biomedical Applications

S. A. Costa, H.S. Azevedo, and R.L. Reis

Use of Chemically Modified Chitosan and Other Natural-Origin Polymers in Tissue Engineering and Drug Delivery

E. T. Baran and R.L. Reis

BIOCOMPATIBILITY AND IMMUNOLOGICAL RESPONSES TO DEGRADABLE BIOMATERIALS

Cytotoxicity Screening of Biodegradable Polymeric Systems

G.A. Silva, A. P. Marques, M.E. Gomes, O. P. Coutinho, and R.L. Reis

Natural-Origin Degradable Materials: The Barrier or the Passage through the Immune System?

P. Marques, J. A. Hunt, and R.L. Reis

Mediation of the Cytokine Network in the Implantation of Orthopedic Devices

P. Marques, J. A. Hunt, and R.L. Reis

Protein and Cell Interactions with Biodegradable Systems

C.M. Alves and R.L. Reis

Surface Activation and Modification - A Way for Improving the Biocompatibility of Degradable Biomaterials

I. Pashkuleva and R.L. Reis

BIODEGRADABLE POLYMERS FOR THE ENGINEERING AND REGENERATION OF DIFFERENT TISSUES

Bone and Articular Cartilage Tissue Engineering: The Biological Components

A.J. Salgado, M.E. Gomes, O. P. Coutinho, and R.L. Reis

Tissue Engineering of the Liver

Y.M. Elcin

Smart Biodegradable Hydrogels with Applications in Drug Delivery and Tissue Engineering

C. Elvira, G.A. Abraham, A. Gallardo, and J. San Román

Skin Tissue Engineering Part I - Review

D.W. Hutmacher, K. W. Ng, and H. L. Khor

Skin Tissue Engineering Part II - The In Vitro Evaluation of Natural and Synthetic 3-D Matrices as Dermal Substrates

K. W. Ng, H. L. Khor, and D.W. Hutmacher

Biodegradable Polymers for Guided Nerve Regeneration

K. Tuzlakoglu and R.L. Reis

INDEX

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
MED009000
MEDICAL / Biotechnology