A Bridge Across Life and Universe
- Available for pre-order. Item will ship after August 15, 2021
Bioenergetics deals with the very first energy transformation steps performed by living cells. Increased dissipation is the major effect of processing external energy packages. Enzyme-supported charge separation is the minor but essential outcome for maintaining life. These two events run together as driving-driven processes. The book explores the usefulness of dissecting the entropy production of enzymes involved in cellular defenses, fermentation, respiration, and photosynthesis, assuming that tightly regulated dissipation is the hallmark of life. This fresh outlook about the essence of life and bioenergetics is in accord with the evolution-coupling hypothesis: biological evolution accelerates the universe’s thermodynamic evolution.
Table of Contents
Introduction. Mitchell’s Chemiosmotic Theory: The Background. Membrane Bioenergetics in a Nutshell. Irreversible Thermodynamics Description How Biochemical Reactions are Coupled or Connected. What is Life? Some Answers to Schrödinger’s Questions. Protonmotive Force. Membrane Proteins. The Maximum Entropy Production: Applications in the Bioenergetics of Bacterial Photosynthesis. Coupling Thermodynamic with Biological Evolution through Bioenergetics. Perfect Enzymes, According to Biochemists. ATP Synthase Molecular Motor. Bacteriorhodopsin: Light-Harvesting Movie Star. The Protonmotive Force in Geochemistry and the Origin Question: Is Origin of Bioenergetices Connected with the Origin of Life? Integrating Glycolysis with Oxidative Phosphorylation by Hexokinases. Bioenergetics of the Brain, Aging, and Cancer Cells as bridged by α-synuclein. Retrospections, Contrasting Viewpoints, Incentives, Challenges, Prospects, and Conclusions.
Davor Juretić is a Professor Emeritus and a scientific adviser at the Mediterranean Institute for Life Sciences in Split, Croatia. His initial education in theoretical physics led to biophysics, bioinformatics, and bioenergetics training in the USA. He established the Biophysics Ph.D. Program at the University of Split. His publications are from the research fields of peptide antibiotics, predictions of membrane buried protein helical segments and applications of the maximum entropy production principle in physics and biology.