2nd Edition

Bioengineering of the Skin Water and the Stratum Corneum, 2nd Edition

    440 Pages 6 Color & 84 B/W Illustrations
    by CRC Press

    Bioengineering of the skin, or more precisely the biophysical assessment of skin physiology, is moving rapidly from a descriptive approach to a deeper understanding of biophysical and biochemical processes. This second edition of the popular text Bioengineering of the Skin: Water and Stratum Corneum reflects the progress in the field, focusing on the dramatically improved understanding of skin physiology. Specifically, it reviews the shift in our understanding of the stratum corneum from an inert surrounding sheet to a biologically active compartment.

    The stratum corneum is the interface between the sometimes harsh environment and the internal turmoil of the human body. Based on a large number of recent publications, this book explains the mechanisms involved in stratum corneum barrier function and hydration. It reflects 10 years of progress not only of the non-invasive biophysical assessment of skin physiology parameter, but also of the perfection of the available devices. It brings all research on epidermal water and transepidermal water loss in health and disease up-to-date with the revision of existing chapters as well as added chapters from new contributors on hydration and itching. This edition also includes new guidelines on the standardization of measurements.

    Bioengineering of the Skin will enhance communication within the research community and will be useful for scientists in the skin bioengineering field by presenting methods that offer reliable and reproducible approaches for product testing in the pharmaceutical and cosmetic industries, as well as for basic research.

    Part I:Introduction
    Water-Lipid Interaction, Bozena B. Michniak, Philip W. Wertz
    Water-Keratin Interaction, Jean-Luc Lévêque
    Stratum Corneum pH: and Ions - Distribution and Importance, Joachim W Fluhr, Lora Bankova, Peter Elias
    Occlusion, Jana Präßler, Joachim W Fluhr

    Part II: Transepidermal Water Loss and Barrier Function
    Transepidermal Water Loss Measurements in Dermato-Cosmetic Sciences, Vera Rogiers, E. Houben, K. De Paepe
    Ultrasound and Water in the Stratum Corneum, Stefania Seidenari, Giovanni Pellacani
    Standardization of Measurements and Guidelines, Grazia Primavera, Joachim W. Fluhr, Enzo Berardesca
    Transepidermal Water Loss (TEWL) and its Relation to Barrier Function and Skin Irritation, P.G.M. Van der Valk, M Kucharekova, R.A. Tupker
    Transepidermal Water Loss and Allergic Contact Dermatitis, Stefania Seidenari, Francesca Giusti
    Prediction of Irritancy, R.A. Tupker
    TEWL and Racial differences, Grazia Primavera, Enzo Berardesca
    Sensitive Skin and Transepidermal Water Loss (TEWL), Clarissa D. Villarama, Howard I. Maibach
    Transepidermal Water Loss and Barrier Function of Aging Human Skin, Klaus-P. Wilhelm, Marianne Brandt, Howard I. Maibach
    Atopic Dermatitis and Other Skin Diseases, Manigé Fartasch
    Transepidermal Water Loss and Dry Skin, Marie Lodén
    Bioengineering Correlates of the Sensitive Skin Syndrome: The Sensory Irritation Component, Robert Sinaiko, Howard I. Maibach
    Barrier Recovery, Silke M. Fuchs, Joachim W. Fluhr, Howard I. Maibach
    Testing the Efficacy of Moisturizer, Bemard Gabard
    Dynamic Measurements: POST, MAT and SDT, Grazia Primavera, Enzo Berardesca

    Part III: Water Content
    Assessment of Stratum Corneum Hydration: Corneometer CM 825, Gabriel Khazaka
    Hardware and Measuring Principles: The NOVATM DPM, Randy Wickett
    Hardware and Measuring Principles: The Computerized DermaLab® TEWL Probe, Gary L. Grove, Charles Zerweck
    Electrical Assessment of Skin Hydration: Standardization of Measurements and Guidelines, Grazia Primavera, Joachim W. Fluhr, Enzo Berardesca
    Hydration and Moisturizers, Marie Lodén
    Infant Skin Hydration, Marty O. Visscher, Steven B. Hoath
    Hydration and Atopic Dermatitis, Chris Edwards
    Within and Beyond the Skin Barrier as Seen by Electrical Impedance , Stig Ollmar, Ingrid Nicander
    Hydration, Psoriasis and Ekzema: The Dry Surface-High Evaporative Water Loss Paradox, Jørgen Serup
    Hydration and Lipids , Philip W. Wertz, Bozena B. Michniak
    Xerotic Skin and Impairment of Barrier Function Associated to Itch, Gil Yosipovitch
    Testing and Efficacy of Barrier Creams, Hongbo Zhai, Howard I. Maibach
    Testing of Moisturizer, Marie Lodén, Magnus Lindberg


    Joachim W. Fluhr, Peter Elsner, Enzo Berardesca