Bioinformatics : A Practical Guide to NCBI Databases and Sequence Alignments book cover
1st Edition

A Practical Guide to NCBI Databases and Sequence Alignments

  • Available for pre-order. Item will ship after December 22, 2021
ISBN 9781032123691
December 22, 2021 Forthcoming by Chapman and Hall/CRC
360 Pages 398 Color & 23 B/W Illustrations

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Book Description

Bioinformatics: A Practical Guide to NCBI Databases and Sequence Alignments provides the basics of bioinformatics and in-depth coverage of NCBI databases, sequence alignment, and NCBI Sequence Local Alignment Search Tool (BLAST). As bioinformatics has become essential for life sciences, the book has been written specifically to address the need of a large audience including undergraduates, graduates, researchers, healthcare professionals, and bioinformatics professors who need to use the NCBI databases, retrieve data from them, and use BLAST to find evolutionarily related sequences, sequence annotation, construction of phylogenetic tree, and the conservative domain of a protein, to name just a few. Technical details of alignment algorithms are explained with a minimum use of mathematical formulas and with graphical illustrations.

Key Features

  • Provides readers with the most-used bioinformatics knowledge of bioinformatics databases and alignments including both theory and application via illustrations and worked examples.
  • Discusses the use of Windows Command Prompt, Linux shell, R, and Python for both Entrez databases and BLAST.
  • The companion website contains tutorials, R and Python codes, instructor materials including slides, exercises, and problems for students.

This is the ideal textbook for bioinformatics courses taken by students of life sciences and for researchers wishing to develop their knowledge of bioinformatics to facilitate their own research.

Table of Contents



The Origin Genomic Information

The Sources of Genomic Data

The NCBI Enterz Databases

NCBI Enterz E-Utilities and Applications

The Entrez Direct

R Package for the NCBI E-Utilities

Pairwise Sequence Alignment

Basic Local Alignment Search Tool


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Hamid D. Ismail received his PhD and M.Sc. in computational science from NC A&T State University, USA and Doctor of Veterinary Medicine (DVM) and Applied Diploma in Statistics and Programming from University of Khartoum, Sudan. He worked as an adjunct professor, bioinformatics specialist, bioinformatics tool developer, a senior scientist, statistician, and database consultant with several institutions. He is currently working as a PhD Research Associate at NC A&T State University. He is a published author in bioinformatics, statistics, machine learning, and bio-science, and he developed a number of bioinformatics desktop and web-based applications. He is also a reviewer for a number of academic journals.




Bioinformatics is a necessary text that will help researchers/students gain background knowledge and understand the usage of NCBI databases. It is well suited for audiences who do not have a bioinformatics background as it defines what genomic data is and the fundamentals of the sequence alignment. It also thoroughly explains how to use NCBI tools to retrieve the researchers' genomic data of interest.

-- Roshonda Jones, Senior Bioinformatics Scientist, Nom Nom