1st Edition

Bioinformatics of the Brain

Edited By Kayhan Erciyes, Tuba Sevimoğlu Copyright 2025
    240 Pages 32 B/W Illustrations
    by CRC Press

    The brain consisting of billions of neurons is probably the most complex and mysterious organ of the body. Understanding the functioning of the brain in its health and disease states has baffled the researchers working in this area for many years. The diversity of brain diseases and disorders makes the analysis of brain functions even a more challenging area of research. In vitro and in vivo studies regarding the brain may be laborious, however, bioinformatics using in silico approaches may take the burden off the experimental studies and give us a clearer perspective on disease and healthy states of the brain, its functions, and disease mechanisms.


    Recent advancements in neuroimaging technologies, development of high- performance computers and development of software, algorithms and methods to analyse data obtained from various neuroimaging processes has opened new frontiers in neuroscience enabling unprecedented finer analysis of the brain functions. This relatively new approach of brain analysis which may be termed Bioinformatics of the Brain is the main subject of this volume aiming to provide a thorough review on various bioinformatics approaches for analyzing the functioning of the brain and understanding brain diseases such as neurodegenerative diseases, brain tumors, and neuropsychiatric disorders. Authors from various disciplines in this volume each focus on a different aspect aiming to expand our understanding of this area of research. Topics included are:

      brain diseases and disorders

      stem cell therapy of neurodegenerative diseases

      tissue engineering applications of gliomas

      brain tumor detection and modeling

      brain tumor growth simulation

      brain-computer interface

      bioinformatics of brain diseases

      graph-theoretical analysis of complex brain networks

      brain proteomics

    This book is intended to aid scientists, researchers, and graduate students in carrying out interdisciplinary research in the areas of bioinformatics, bio- engineering, computer engineering, software engineering, mathematics, molecular biology, genetics, and biotechnology.


    About the Editors

    List of Contributors

    1       BRAIN DISEASES AND DISORDERS                                                         

    Tuba Sevimoglu, Tugba Bal, and C¸ ağla O¨zdemir

    2       Therapeutic Potential Of Stem Cells In Neurodegenerative Diseases                                                                      

     Zihni Onur Çalışkaner

    3       Tissue Engineered Models of Brain Tumors and Their Appli- cations                                                                      

    Tugba Bal

    4       BrainTumorDetectionUsingImageProcessingTechniques

    Kristin Surpuhi Benli

    5       Tumor Growth Simulation                                                                                        

    Ihab ELAFF

    6       Mathematical Modelling for Brain Tumors Including Fractional Operator                                                                      

    Arife Aysun Karaaslan

    7       EEG-based BCI systems in Neuropsychiatric Diseases                                                                                        

    Emine Elif Tu¨lay

    8       Bioinformatics of Brain Diseases                                                                                        

    Tuba Sevimoglu

    9       Complex Brain Networks: A Graph-Theoretical Analysis                                                                                        

    Kayhan Erciyes

    10   Brain Proteomics                                                                                        

    Saime Su¨rmen and Mustafa Gani Su¨rmen           



    Kayhan Erciyes holds a B.Sc. (Hons.) in Electrical Eng. and Electronics from the University of Manchester Institute of Science and Technology, England, an M.Sc. degree in Electronic Control Eng. from the University of Salford, England and a Ph.D. degree in Computer Eng. from Ege University, Turkiye with part of the Ph.D. study realized at Edinburgh University, Scot- land. He has worked as a Professor in a number of institutions including Ege University, Maltepe University, Yasar University, Uskudar University, Izmir Institute of Technology, UC Davis, Oregon State University and California State University San Marcos. He has published several books including Distributed and Sequential Algorithms for Bioinformatics by Springer Computational Biology Series. His research interests are broadly in graph theory and its applications in bioinformatics and brain networks, and parallel and distributed algorithms.


    Tuba Sevimoglu holds a B.Sc. in Chemical Engineering from Yildiz Technical University, Turkiye, an M.Sc. degree in Industrial Engineering from Florida International University, USA and a Ph.D degree in Bioengineering from Mar- mara University, Turkiye. She is currently a Professor of Bioengineering at University of Health Sciences in Istanbul, Turkiye. Her research interests include bioinformatics approaches to analyzing big data, gene expression, biological networks and the bioinformatics of genetic, neurodegenerative and autoimmune diseases.