416 pages | 90 B/W Illus.
Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of toxicology in years to come including proteomics, toxicogenomics, and metabonomics, this expertly conceived guide explores toxicological issues of particular world interest, such as toxicity of nanomaterials, military jet fuels, and genetically-modified foods.
Introduction and Overview. NEW CONCEPTS AND APPROACHES. Toxicogenomics: Gene Expression Analysis and Computational Tools. Proteomics. The Potential of Metabonomics in Toxicology. Quantitative Structure-Toxicity Relationships Using Chemodescriptors and Biodescriptors. Hormesis: A Key Concept in Toxicology. Chemical Risk Assessment. Toxicokinetics: Fundamentals and Applications in Drug Development and Safety Assessment. Validation of In Vitro Methods for Toxicology Studies. Chemical Mixtures Risk Assessment and Technological Advances. EXAMPLES APPLIED TO PROBLEMS. Risk-Based Approach to Foods Derived for Genetically Engineered Animals. Toxicology of Nanomaterials. The Biological Basis of Experimental Toxicity of Jet Propulsion Fuel-8. Drug Safety Toxicology. Statins and Toxicity. Inhalation Toxicology. Modern Gas Chromatography/Mass Spectrometry in Human Forensic Toxicology