1st Edition
Biology of Oral Cancer Key Apoptotic Regulators
Cancer: A Worldwide Menace
Epidemiology
Diagnosis and Pathology
Conclusion
References
Oral Cancer
Key Words
Introduction
Epidemiology
Signs and Symptoms
Sex and Age Distribution
Etiology
Pathology
Staging
Individual Cancers of the Oral Cavity
Conclusion
References
Proliferative and Apoptotic Signaling in Oral Cancer
Key Words
Introduction
Regulation of Cell Homeostasis
Somatic Gene Mutation
Oncogenes and Tumor Suppressors
NF-κB
Serine/Threonine Kinases
Steroid Hormones
Central Role of Caspases
Caspases Inhibitory Proteins
Death Domains
Fas/Fas Ligand
TRAIL and Its Receptors
Conclusion
References
Apoptotic Regulations
Key Words
Introduction
Etymology
Mechanisms of Apoptosis in Cancer
Role of Apoptotic Regulators in Rheumatoid Arthritis (RA)
Role of Apoptotic Regulators in Prostate Carcinoma
Conclusion
References
Dynamics of p53 in Oral Cancer
Key Words
Introduction
Functions and Roles in Causing Disease
p53 as an Oncogene
p53 as a Tumor Suppressor
Mutations in p53
Apoptotic Regulation by p53
Interplay between Survivin and p53
Clinicopathological Significance of p53
Therapeutic Strategies Targeting p53
Conclusion
References
Diagnostic and Therapeutic Potential of Apoptotic Marker
Key Words
Introduction
Apoptotic Markers in Oral Cancer Therapeutics
Apoptotic Markers in Oral Cancer Diagnostics
Conclusion
References
Expression and Regulation of Survivin
Key Words
Introduction
Molecular Organization and Structure of Survivin
Functions of Survivin
Regulation of Survivin
Anti-Apoptotic Network of Survivin
Expression of Survivin in Normal Tissues
Expression of Survivin in Human Cancer
Conclusion
References
Therapeutics of Survivin
Key Words
Introduction
Manipulation of the Survivin Gene
Factors Inducing Survivin Expression
Downregulation of Survivin
Ribozyme-Mediated Degradation of Survivin
Immunotherapy
Therapeutic Biology of Survivin
Survivin-Directed Cancer Therapy
Regulation of Survivin in Head and Neck Squamous Carcinoma
Prognostic and Diagnostic Significance of Survivin
Therapeutic Approach
Survivin for Cancer Immunotherapy
Conclusion
References
Molecular Diagnosis of Oral Cancer
Key Words
Introduction
Molecular Markers for Oral Cancer
Molecular Mechanism of Development of Oral Cancer
The Hallmarks of Oral Cancer
Other Markers
Diagnosis of Oral Squamous Cell Carcinoma
Conclusion
References
Glossary
Index
Biography
Prakash S. Bisen, Zakir Khan, Saurabh Bundela
