Biology of Oral Cancer: Key Apoptotic Regulators, 1st Edition (Paperback) book cover

Biology of Oral Cancer

Key Apoptotic Regulators, 1st Edition

By Prakash S. Bisen, Zakir Khan, Saurabh Bundela

CRC Press

292 pages | 65 B/W Illus.

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Description

Despite a decline in developed countries, cancer has consistently maintained its status as one of the top killers since time immemorial. Exploring cancer management and treatment at the molecular level, Biology of Oral Cancer: Key Apoptotic Regulators presents a key molecular event—apoptosis—in relation to genesis and progression of oral cancer. The book uses oral cancers as the specific means to demonstrate the use of apoptotic regulators for controlling cancers. 

The book comprehensively deals with the different aspects of oral cancer. The authors discuss strategies to leverage apoptotic regulatory mechanisms for better management along with state-of-the-art medical options available for management and treatment. Using an informal writing style that makes the information accessible to a wider audience, each chapter begins with a prologue followed by detailed discussion and concludes with a glimpse into future approaches and challenges. The book examines detection techniques that leverage molecular events associated with oral carcinogenesis to effectively detect oral cancer.

A thorough examination of the internal (genetics) and external (carcinogens, radiation, and smoking) factors that cause cancer, the book provides an enhanced understanding of why oral cancer has consistently ranked among the top ten causes of cancer-related mortalities worldwide. It furthers the effective identification of the causal factors and their modulation that can restore cells’ normal state and be used to develop increasingly effective modalities.

Table of Contents

Cancer: A Worldwide Menace

Epidemiology

Diagnosis and Pathology

Conclusion

References

Oral Cancer

Key Words

Introduction

Epidemiology

Signs and Symptoms

Sex and Age Distribution

Etiology

Pathology

Staging

Individual Cancers of the Oral Cavity

Conclusion

References

Proliferative and Apoptotic Signaling in Oral Cancer

Key Words

Introduction

Regulation of Cell Homeostasis

Somatic Gene Mutation

Oncogenes and Tumor Suppressors

NF-κB

Serine/Threonine Kinases

Steroid Hormones

Central Role of Caspases

Caspases Inhibitory Proteins

Death Domains

Fas/Fas Ligand

TRAIL and Its Receptors

Conclusion

References

Apoptotic Regulations

Key Words

Introduction

Etymology

Mechanisms of Apoptosis in Cancer

Role of Apoptotic Regulators in Rheumatoid Arthritis (RA)

Role of Apoptotic Regulators in Prostate Carcinoma

Conclusion

References

Dynamics of p53 in Oral Cancer

Key Words

Introduction

Functions and Roles in Causing Disease

p53 as an Oncogene

p53 as a Tumor Suppressor

Mutations in p53

Apoptotic Regulation by p53

Interplay between Survivin and p53

Clinicopathological Significance of p53

Therapeutic Strategies Targeting p53

Conclusion

References

Diagnostic and Therapeutic Potential of Apoptotic Marker

Key Words

Introduction

Apoptotic Markers in Oral Cancer Therapeutics

Apoptotic Markers in Oral Cancer Diagnostics

Conclusion

References

Expression and Regulation of Survivin

Key Words

Introduction

Molecular Organization and Structure of Survivin

Functions of Survivin

Regulation of Survivin

Anti-Apoptotic Network of Survivin

Expression of Survivin in Normal Tissues

Expression of Survivin in Human Cancer

Conclusion

References

Therapeutics of Survivin

Key Words

Introduction

Manipulation of the Survivin Gene

Factors Inducing Survivin Expression

Downregulation of Survivin

Ribozyme-Mediated Degradation of Survivin

Immunotherapy

Therapeutic Biology of Survivin

Survivin-Directed Cancer Therapy

Regulation of Survivin in Head and Neck Squamous Carcinoma

Prognostic and Diagnostic Significance of Survivin

Therapeutic Approach

Survivin for Cancer Immunotherapy

Conclusion

References

Molecular Diagnosis of Oral Cancer

Key Words

Introduction

Molecular Markers for Oral Cancer

Molecular Mechanism of Development of Oral Cancer

The Hallmarks of Oral Cancer

Other Markers

Diagnosis of Oral Squamous Cell Carcinoma

Conclusion

References

Glossary

Index

Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
MED062000
MEDICAL / Oncology
SCI017000
SCIENCE / Life Sciences / Cytology
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology