1st Edition

Biomarkers as Targeted Herbal Drug Discovery A Pharmacological Approach to Nanomedicines

    362 Pages 14 Color & 16 B/W Illustrations
    by Apple Academic Press

    362 Pages 14 Color & 16 B/W Illustrations
    by Apple Academic Press

    362 Pages 14 Color & 16 B/W Illustrations
    by Apple Academic Press

    This new volume looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits.

    Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous potential in healthcare. Conventional medications have limited efficacy and high toxicity, whereas herbal drugs are said to provide wide structural diversity that is not usually seen with conventional/synthetic drug molecules. Recognition of various herbal constituents, such as terpenoids, fatty acids, flavonoids and steroids, are well explored in the management and treatment of various disorders in this volume. These agents target various biomarkers such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic acid.

    Biomarkers as Targeted Herbal Drug Discovery: A Pharmacological Approach to Nanomedicines discusses phytoconstituent-based nanotherapeutics with applications for some specific health issues, such as arthritis, leishmanicidal, cardiovascular diseases, cancer, ocular disorders, etc.

    1. Inflammatory Biomarkers: An Important Tool for Herbal Drug Discovery

    Mahfoozur Rahman, Ankit Sahoo, Mohammad Atif, and Sarwar Beg

    2. Herbal Anti-Arthritic Drug Discovery Tool Based on Inflammatory Biomarkers

    Mahfoozur Rahman, Ankit Sahoo, and Sarwar Beg

    3. Curcumin Nanomedicines and Their Application in the Management of Disease

    Sadaf Jamal Gilani et al.

    4. Ursolic Acid: A Pentacyclic Triterpene from Plants in Nanomedicine

    Monalisha Sen Gupta et al.

    5. Phytoconstituent-Centered Byproducts and Nanomedicines as Leishmanicidal Scavengers

    Sabya Sachi Das, P. R. P. Verma, and Sandeep Kumar Singh

    6. Delivery of Herbal Cardiovascular Drugs in the Scenario of Nanotechnology: An Insight

    Kumar Anand et al.

    7. Nigella sativa Encapsulated Nano-Scaffold and Their Bioactivity Significance

    Mohammed Asadullah Jahangir et al.

    8. Phytoconstituent-Loaded Nanomedicines for Arthritis Management

    Syed Salman Ali et al.

    9. Phytoconstituent-Based Nanotherapeutics as Ocular Delivery Systems

    Mohammed Jafar, Syed Sarim Imam, and Syed Azizullah Ghori

    10. Rosmarinic Acid: A Boon in the Management of Cardiovascular Disease

    Md. Adil Shaharyar et al.

    11. Long-Term Toxicity and Regulations for Bioactive-Loaded Nanomedicines

    Iqbal Ahmad et al.

    12. Resveratrol-Loaded Phytomedicines for Management of Cancer

    Shakir Saleem, Ruqaiyah Khan, and Sandeep Arora

    13. Thymoquinone-Loaded Nanocarriers for Healthcare Applications

    Ruqaiyah Khan, Himani Nautiyal, and Shakir Saleem


    Mahfoozur Rahman, PhD, is Assistant Professor in the Department of Pharmaceutical Sciences, Faculty of Health Science, Sam Higginbottom University of Agriculture, Technology and Sciences (SHUATS), Allahabad, India. He has published over 100 journal papers as well as book chapters and books. He also serves as an editorial board member and guest editor for several journals.

    Sarwar Beg, PhD, is Assistant Professor in the Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. He has over a decade of teaching and research experience in the field of pharmaceutics and biopharmaceutics. Dr. Beg was formerly a Research Scientist at Jubilant Generics Limited, India.

    Mazin A. Zamzami, PhD, is Associate Professor in Clinical Biochemistry and the Chairman of the Biochemistry Department, Faculty of Science at King Abdulaziz University, Kingdom of Saudi Arabia. Previously, Dr. Zamzami directed the Serology Department as well as worked as a senior laboratory technician in the Clinical Biochemistry Department at Al-Thagher Hospital, Jeddah, Saudi Arabia.

    Hani Choudhry, PhD, is Assistant Professor of Cancer Genomics and the Head of Cancer and Mutagenesis Unit at the King Fahd Center for Medical Research at King Abdulaziz University, Saudi Arabia, as well as a Visiting Assistant Professor at the NIH Center of Excellence in Genomic Science, Center for Personal Dynamic Regulome, School of Medicine, Stanford University, California.

    Aftab Ahmad, PhD, is Associate Professor of Pharmacology in the Health Information Technology Department at Jeddah Community College of King Abdulaziz University, Kingdom of Saudi Arabia. He has completed many research projects as a principal investigator funded by the deanship of scientific research of King Abdulaziz University and has published many research articles.

    Khalid S. Alharbi, PhD, is Assistant Professor of Pharmacology and Toxicology and the Head of the Pharmacology Department, College of Pharmacy at Jouf University, Saudi Arabia. He has published several articles in peer-reviewed journals and has presented papers at numerous international conferences.

    “A very interesting compilation of the translational components of the science and technology that, in particular, focuses on their herbal drug delivery and targeting on various biomarkers, which are involved in the treatment of various dreadful disorders, including arthritis, cardiovascular, ocular disorders, cancers, etc. . . . An important tool for herbal drug discovery based on biomarkers. . . . [Also] discusses herbal constituents to target the biomarkers involved in various threatening diseases, including parasitic disease, immune-related disorders, cancers, etc., and its management by using bioactive loaded nanomedicines . . . A wonderful treatise based on expert experience with a clear bearing on application in human health.”

    —From the Foreword by Professor Rajendra B. Lal, Vice Chancellor, Sam Higginbottom University of Agriculture, Technology and Science, India