This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.
Table of Contents
Biomarker Technology. Neuro-proteomics and Neuro-systems Biology in the Quest of TBI Biomarker Discovery . Proteomic and Other "Omic" Approaches to Traumatic Brain Injury . Molecular Mechanisms and Biomarker Perspective of MicroRNAs in Traumatic Brain Injury . Necrosis, Apoptosis and Autophagy in Acute Brain Injury: The Utilities of Biomarkers . Acute, Subacute and Chronic Biomarkers for CNS Injury . Biomarkers for Differential Calpain Activation in Healthy and Diseased Brain; A Systematic Review. CNS Injury Biomarkers. Biomarkers for Mild Traumatic Brain Injury . Social Relationship, Health and Physiological Process: Implications for Brain Injury Recovery . Rehabilomics Concepts: An Overview of Genetic, Proteomic, and Hormonal Biomarkers in TBI Recovery. Clinical Biomarkers: Neurotherapeutics and Recovery from Traumatic Brain Injury . Inflammatory Biomarkers of Brain. Injury and Disease . Biomarkers in Spinal Cord Injury . Imaging Biomarkers for Traumatic Brain Injury. Other CNS Disorder Biomarkers. miRNA as Biomarkers of Multiple Sclerosis: Quest for Identification and Treatment . Putative Protein Biomarkers of Multiple Sclerosis . Various Types of Multiple Sclerosis Biomarkers . Biomarkers and Neurodegenerative Diseases: Promising Inroads Toward a Distant Goal . Biomarkers of Apoptosis and Inflammation in Neurodegenerative Disorders . Charcot-Marie-Tooth Disease: Implication of Molecular Mechanisms, Biomarkers and Therapeutic Approaches . Alpha-Synuclein and 14-3-3 Proteins as Biomarkers of Neurodegenerative Diseases . Brain Stimulation in Neuropsychological Disorders: Potential for Biomarker . Biomarkers of Nerve Regeneration in Peripheral Nerve Injuries: An Emerging Field . Biomarkers of Drug Abuse-induced Brain Changes: Neuroinflammation and Microglial Role in Alcohol Exposure.
Kevin K. W. Wang, Zhiqun Zhang, Firas H. Kobeissy