1st Edition

Biomarkers of Environmental Contamination

By 0 McCarthy Copyright 1990

    How can biological markers help assess and predict human health risks? Find out the answers to this question and others in this timely new book examining the use of biological markers in animals and plants for evaluating the ecological and health effects of environmental contamination. The book explains the concept of environmental sentinels, presents example of field studies and discusses the utility of biomarkers within a risk analysis paradigm. Anyone who needs to know how to assess and predict environmental contamination should consider this book essential reading.

    SECTION ONE: OVERVIEW, 1. Biological Markers of Environmental Contamination, SECTION TWO: ANATOMICAL AND CYTOLOGICAL ENDPOINTS, 2. Liver Structural Alterations Accompanying Chronic Toxicity in Fishes: Potential Biomarkers of Exposure, 3. Histopathology of Atlantic Tomcod: A Possible Monitor of Xenobiotics in Northeast Tidal Rivers and Estuaries, 4. The Croaker (Nibea mitsukurii) and the Sea Catfish (Plotosus anguillaris): Useful Biomarkers of the Coastal Pollution, SECTION THREE: DETOXICATION, ADAPTIVE AND IMMUNOLOGICAL RESPONSES, 5. Sublethal Responses of Platichthys stellatus to Organic Contamination in San Francisco Bay with Emphasis on Reproduction, 6. Hepatic Enzymes as Biomarkers: Interpreting the Effects of Environmental Physiological and Toxicological Variables, 7. Avian Mixed Function Oxidase Induction as a Monitoring Device: The Influence of Normal Physiological Functions, 8. Use of Barbiturate-Induced Sleeping Time as an Indicator of Exposure to Environmental Contaminants in the Wild, 9. Stress Proteins: Potential as Multitiered Biomarkers, 10. Macrophage Responses of Estuarine Fish as Bioindicators of Toxic Contamination, SECTION FOUR: GENOTOXIC RESPONSES, 11. Biological Monitoring: Testing for Genotoxicity, 12. DNA Adducts in Marine Mussel Mytilus galloprovincialis Living in Polluted and Unpolluted Environments, 13. c-K-Ras Oncogenes: Prevalence in Livers of Winter Flounder from Boston Harbor, SECTION FIVE: METAL METABOLISM, 14. Metal-Binding Proteins and Peptides for the Detection of Heavy Metals in Aquatic Organisms, 15. Metallothionein as a Biomarker of Environmental Metal Contamination, 16. Metallothionein: A Potential Biomonitor of Exposure to Environmental Toxins, 17. Effect of Cadmium on Protein Synthesis in Gill Tissue of the Sea Mussel, Mytilus edulis, SECTION SIX: APPLICATION OF BIOMARKERS IN FIELD EVALUATION, 18. Sentinel Species and Sentinel Bioassay, 19. Application of Bioindicators in Assessing the Health of Fish Populations Experiencing Contaminant Stress, 20. A Comparative Evaluation of Selected Measures of Biological Effects of Exposure of Marine Organisms to Toxic Chemicals, 21. Disease Biomarkers in Large Whale Populations of the North Atlantic and Other Oceans, 22. Use of Biomarkers in Ecological Risk Assessment, CONCLUDING REMARKS, 23. Concluding Remarks: Implementation of a Biomarker-Based Environmental Monitoring Program, List of Authors, Index


    0 McCarthy