1st Edition

Biomaterials and Immune Response Complications, Mechanisms and Immunomodulation

Edited By Nihal Engin Vrana Copyright 2019
    264 Pages
    by CRC Press

    263 Pages 23 Color & 11 B/W Illustrations
    by CRC Press

    263 Pages 23 Color & 11 B/W Illustrations
    by CRC Press

    The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials.

    • Provides keen insight into biomaterial–immune cell interactions

    • Presents an explanation of state-of-the-art methodologies in immunomodulation

    • Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic

    • Explores a comprehensive overview of biomaterial related complications

    • Provides extensive references at the end of each chapter to enhance study for this very hot research area



    Editorial: Biomaterials and Immune Response; Introduction to Immune Cells and Their Roles in Response to Biomaterials. Macrophange Plasticity and Foreing Body Response. The Effects of Biomaterials with Micro/Nanotopographies on Immune Cells in Vitro and in Vivo. Immune Response to Nanoparticles. Surface Chemistry and Immunce Response. Hyaluronic Acid as a Biomaterial and its Role in the Immune System. Bacterial Attachment and Biofilm Formation on Biomaterials: The Case of Dental and Orthopaedic Implants. Osteoimmunomodulation with Biomaterials. Macrophange Based Immunomodulation for Biomaterial Applications.


    Dr. Nihal Engin Vrana is Vice-President of Scientific Affairs at PROTIP Medical. He obtained his PhD in 2009 at Dublin City University as a Marie Curie ESR Fellow. His major research interests are titanium implants, tissue engineering, cell encapsulation, immunodulation, real-time monitoring and implants and cell biomaterials and cell biomaterials interactions. He has published over 55 articles in peer reviewed academic journals, 4 book chapters and holds three European patents. He holds three ESB Translational Research Awards.