1st Edition

Biomaterials and Stem Cells in Regenerative Medicine

    564 Pages 81 B/W Illustrations
    by CRC Press

    564 Pages 81 B/W Illustrations
    by CRC Press

    Work in the area of biomaterials and stem cell therapy has revealed great potential for many applications, from the treatment of localized defects and diseases to the repair and replacement of whole organs. Researchers have also begun to develop a better understanding of the cellular environment needed for optimal tissue repair and regeneration. Biomaterials and Stem Cells in Regenerative Medicine explores a range of applications for biomaterials and stem cell therapy and describes recent research on suitable cell scaffolds and substrates for tissue repair and reconstruction.

    Featuring contributions by experts in the field, the book explores important scientific and clinical aspects. It covers the basic science involved in structure and properties, techniques and technological innovations in processing and characterization, and applications of biomaterials and stem cells.

    Topics include:

    • Polymeric systems for stem cell delivery
    • The potential of membranes and porous scaffolds in tissue repair, including myocardial, periodontal, ophthalmic, and bone tissues
    • The optimization of the interaction between stem cells and biomaterial substrates
    • The source and nature of stem cells for tissue engineering applications
    • The clinical translation of stem cell–based tissue engineering for regenerative medicine

    From fundamental principles to recent advances at the macro, micro, nano, and molecular scales, the book brings together current knowledge on biomaterials and stem cells in the context of regenerative medicine. It also stimulates discussion about future research directions.

    This unique book offers a valuable benchmark for the current status of clinically relevant research and development in stem cells and regenerative medicine. It bridges the gaps in experimental approaches and understanding among the materials science and engineering, biological sciences, and biomedical science and engineering communities, making it a valuable reference for graduate students, researchers, and practitioners working in the multidisciplinary field of biomedical research.

    Identification and Application of Polymers as Biomaterials for Tissue Engineering and Regenerative Medicine
    Claire N. Medine, Ferdous Khan, Salvatore Pernagallo, Rong Zhang, Olga Tura, Mark Bradley, and David C. Hay

    Hydrogel as Stem Cell Niche for In Vivo Applications in Regenerative Medicine
    Xiaokang Li, Claudia Wittkowske, Rui Yao, and Yanan Du

    Fabrication and Application of Gradient Hydrogels in Cell and Tissue Engineering
    Azadeh Seidi, Serge Ostrovidov, and Murugan Ramalingam

    Smart Biomaterial Scaffold For In Situ Tissue Regeneration
    Jaehyun Kim, Sunyoung Joo, In Kap Ko, Anthony Atala, James J. Yoo, and Sang Jin Lee

    Fabrication of 3D Scaffolds and Organ Printing for Tissue Regeneration
    Ferdous Khan and Sheikh Rafi Ahmad

    Natural Membranes as Scaffold for Biocompatible Aortic Valve Leaflets: Perspectives from Pericardium?
    Maria Cristina Vinci, Francesca Prandi, Barbara Micheli, Giulio Tessitore, Anna Guarino, Luca Dainese, Gianluca Polvani, and Maurizio Pesce

    Spatially Designed Nanofibrous Membranes for Periodontal Tissue Regeneration
    Marco C. Bottino, Yogesh K. Vohra, and Vinoy Thomas

    Autoinductive Scaffolds for Osteogenic Differentiation of Mesenchymal Stem Cells
    Esmaiel Jabbari and Murugan Ramalingam

    Ophthalmic Applications of Biomaterials in Regenerative Medicine
    Victoria Kearns, Rosalind Stewart, Sharon Mason, Carl Sheridan, and Rachel Williams

    Calcium Phosphates as Scaffolds for Mesenchymal Stem Cells
    Iain R. Gibson

    Bioactive Glasses as Composite Components: Technological Advantages and Bone Tissue Engineering Applications
    Elzbieta Pamula, Katarzyna Cholewa-Kowalska, Mariusz Szuta, and Anna M. Osyczka

    Processing Metallic Biomaterials for a Better Cell Response
    Ioana Demetrescu, Daniela Ionita, and Cristian Pirvu

    Osteogenic Adult Stem Cells and Titanium Constructs for Repair and Regeneration
    Marcus J. Tillotson and Peter M. Brett

    Stem Cell Response to Biomaterial Topography
    Luong T.H. Nguyen, Susan Liao, Casey K. Chan, and Seeram Ramakrishna

    Growth Factors, Stem Cells, Scaffolds and Biomaterials for Tendon Regeneration
    James Zhenggui Tang, Guo-Qiang Chen, and Nicholas R. Forsyth

    Biomaterials and Stem Cells for Myocardial Repair
    Jiashing Yu, Chao-Min Cheng, and Randall J. Lee

    Perinatal Stem Cells in Regenerative Medicine
    Bridget M. Deasy, Jordan E. Anderson, Kelley J. Colopietro, and Yong Li

    Adult Stem Cell Survival Strategies
    Melanie Rodrigues, Linda G. Griffith, and Alan Wells

    Immunobiology of Biomaterial/Mesenchymal Stem Cell Interactions
    Peiman Hematti and Summer Hanson

    Autologous Mesenchymal Stem Cells for Tissue Engineering in Urology
    Guihua Liu, Chunhua Deng, and Yuanyuan Zhang

    Umbilical Cord Matrix Mesenchymal Stem Cells: A Potential Allogenic Cell Source for Tissue Engineering and Regenerative Medicine
    N.S. Remya and Prabha D. Nair

    Human Embryonic Stem Cells and Tissue Regeneration
    Odessa Yabut, Carissa Ritner, and Harold S. Bernstein

    Clinical Applications of Mesenchymal Stem Cell–Biomaterial Constructs for Tissue Reconstruction
    Summer Hanson and Peiman Hematti

    Clinical Aspects of the Use of Stem Cells and Biomaterials for Bone Repair and Regeneration
    Roger A. Brooks

    Clinical Translation of Tissue Engineering and Regenerative Medicine Technologies
    Alejandro Nieponice



    Murugan Ramalingam is an associate professor of biomaterials and tissue engineering at the Institut National de la Santé et de la Recherche Médicale U977, Faculté de Chirurgie Dentaire, University of Strasbourg (UdS), France. Concurrently, he holds an adjunct associate professorship at Tohoku University, Japan. He has authored over 125 publications, including several patents, relevant to biomaterials and tissue engineering. He serves on the editorial boards of multiple journals, including as editor-in-chief of the Journal of Bionanoscience and the Journal of Biomaterials and Tissue Engineering. For more about Dr. Ramalingam, see his profile on the University of Strasbourg’s Biomaterials Group website.

    Seeram Ramakrishna, FREng, FNAE, FAIMBE, is a professor of materials engineering at the National University of Singapore. He pioneered translucent biomaterials and devices, which are now marketed globally. He specializes in the design, processing, and validation of biomimetic scaffolds for the regeneration of various tissues. He is acknowledged as the number one in the field of materials by electrospinning. Ramakrishna has authored five books and over 400 international journal papers, which has attracted approximately 14,000 citations with an h-index of 54. For more about Dr. Ramakrishna, see his profile on the National University of Singapore website.

    Serena Best is a professor at the Cambridge Centre for Medical Materials within the Department of Materials Science and Metallurgy, University of Cambridge. She has more than 130 publications in the field of biomaterials, and her work has contributed to the formation of two successful spinout companies. Her interests currently encompass the development of bioactive ceramics, coatings, and composites for various biomedical applications. Dr. Best is an editor of the Journal of Materials Science: Materials in Medicine and also sits on several editorial boards, including the Journal of the Royal Society Interface. For more about Dr. Best, see her profile on the University of Cambridge website.

    "This book represents a key stone to clarify and understand all the problems connected with the use of stem cells and biomaterials in regenerative medicine, supplying to the readers all the innovations actually in study or ready in the market. All the reported information enriched by many interesting and updated references, may be useful for researchers and industrial experts, as well as students who wish to better know and enter into this fascinating and new medical field, understanding also the reasons and necessities for future innovations."
    Journal of Applied Cosmetology January/June 2013