1st Edition

Biomedical Nanosensors

Edited By Joseph M. Irudayaraj Copyright 2012
    410 Pages 32 Color & 98 B/W Illustrations
    by Jenny Stanford Publishing

    This book draws together recent data on both cytoplasmic and flagellar dyneins and the proteins they interact with, to give the reader a clear picture of what is currently known about the structure and mechanics of these remarkable macro-molecular machines. Each chapter is written by active researchers, with a focus on currently used biophysical, biochemical, and cell biological methods. In addition to comprehensive coverage of structural information gained by electron microscopy, electron cryo-tomography, X-ray crystallography, and nuclear magnetic resonance, this book provides detailed descriptions of mechanistic experiments by single-molecule nanometry.

    Biomolecular Components of a Biosensor: Fundamentals, Kaustubh D. Bhalerao and Goutam J. Nistala
    What Makes a Biosensor a Biosensor?
    The Recognition Layer
    Conclusions and Future Outlook

    Macromolecule-Imprinted Polymers: Antibody/Receptor Mimics for Protein Recognition and Catalysis,
    Yun Peng, David W. Britt, Marie K. Walsh, and Timothy Doyle

    Chemical and Biological Sensing and Imaging Using Plasmonic Nanoparticles and Nanostructures, Qi Wang and Chenxu Yu
    Theoretical Background of nanoSPR
    Synthesis, Fabrication, and Functionalization of Plasmonic Nanostructures
    Application of nanoSPR in Chemical and Biological Sensing
    Conclusions and Future Perspectives

    Surface-Raman Scattering for Medical Applications, Mustafa Çulha
    Introduction to Raman Scattering and Surface-Enhanced Raman Scattering
    Applications of SERS in Biomedical Sciences and Medicine
    Concluding Remarks and Future Outlook

    Diagnostic and Therapeutic Applications of Carbon Nanotubes,
    Balaji Panchapakesan, Thomas Burkhead, Ben King, Peng Xu, James Loomis, and Eric Wickstrom
    Nanotechnology for Cancer
    Carbon Nanotubes
    Electronic Properties of Carbon Nanotubes
    Optical Properties of Carbon Nanotubes
    Biological Applications of Carbon Nanotubes
    Bioelectronic Devices Based on Carbon Nanotubes
    Applications of Nanotube Transistors for Detecting Circulating Cancer Cells
    Integrated Molecular Targeting and Selective Photothermal Therapy of Breast Cancer Cells Using Carbon Nanotubes
    Conclusions and Future Applications of Carbon Nanotubes for Biomedical

    Graphene for Biosensing Applications, Romaneh Jalilian, Luis A. Jauregui, Kyuwan Lee, Yong P. Chen, and Joseph Irudayaraj
    Fabrication of Graphene-Based Materials and Devices
    Basic Properties of Graphene
    Biosensing Applications of Graphene
    Closing Remarks and Future Work

    Single-Molecule Fluorescence Spectroscopy Techniques for Biomedicine,
    Jose M. Moran-Mirabal, Harold G. Craighead, and Larry P. Walker
    Single-Molecule Fluorescence Spectroscopy Fundamentals
    Experimental Implementations of SMFS Techniques
    Observables Measured with SMFS Techniques
    Micro- and Nanostructured Surfaces for SMFS
    Micro- and Nanofluidic Slits and Channels
    Potential Biomedical SMFS Applications

    Particle Engineering for Inhalational Drug Delivery,
    Basma Ibrahim, Yan Yang, and Yoon Yeo
    Dry Particles for Inhalational Therapy
    Traditional Particle Manufacturing for Inhalational Drug Delivery
    NPs for Inhalational Drug Delivery

    Devices and Sensors for Bioelectric Monitoringand Stimulation,
    Benjamin Moody, Mathew K. Zachek, and Gregory S. McCarty
    Electrode Basics
    Electrochemical Measurements
    Biosensor Electrodes
    Advances in Electrodes for Biological Measurements
    Applications in the Brain
    Applications to the Heart and Muscles

    Microelectromechanical Systems for in vivo Therapeutics,
    Masaru P. Rao
    Advantageous Features of MEMS
    The MEMS "Tool Kit": Common MEMS Materials and Fabrication Techniques
    Selected Examples of Application Areas within in vivo Therapeutics
    In vivo Therapeutic MEMS Enabled by Titanium Micromachining
    Conclusions and Outlook

    Implantable Electrochemical Biosensors: A Perspective, Sridhar Govindarajan and Bella B. Manshian
    In vivo Monitoring — Challenges and Progress


    Joseph M. Irudayaraj

    "Biomedical nanosensors have a wide range of applications in human, animal, and plant health for diagnostics and therapeutics. Assembled by Prof. Joseph Irudayaraj, this book is an important reference in the exciting, important, and rapidly evolving field of biomedical nanotechnology. The chapters are detailed and thorough, and rich with references. It is an interdisciplinary collection of contributions from experts with diverse backgrounds, and therefore a very interesting and educational read for students and faculty researchers in bionanotechnology."
    —Prof. Rashid Bashir - University of Illinois at Urbana-Champaign, USA

    "This book gives an inspirational overview on current developments in nanomaterial and nanoarchitecture for advanced sensing applications in the fields of medical diagnostics and therapeutics agents for drug delivery. It focuses on the nanoscale perspective of materials properties towards new sensing strategies to study the biological systems with improved sensitivity, to characterize molecular interaction and cellular mechanisms at molecular or cellular dimension. The content is comprehensive and rich in references covering the topics on fundamental biosensor design, natural and synthetic biorecognition elements, inorganic nanomaterials such as gold nanoparticles and carbon nanotube-based sensors, engineered nanoparticles for drug delivery, and nanoarchitecture and nanodevices towards implantable sensing. Each chapter is provided with a clear and brief introduction, the sub-topics are well organized and easy to follow, and summarized with a prospective and future outlook. . . .

    I am very impressed by the concise and informative content of this . . . very useful reference work for research scientists working in the field of nanotechnology, as well as high school teachers and university students to get an overview on the topic of biomedical nanosensors."

    —Dr. W. C. Mak, Biosensors and Bioelectronics Centre, Department of Physics, Chemistry and Biology, Linköping University, Sweden