2nd Edition

Biomedical Photonics Handbook Biomedical Diagnostics

Edited By Tuan Vo-Dinh Copyright 2015
    889 Pages 367 B/W Illustrations
    by CRC Press

    889 Pages 367 B/W Illustrations
    by CRC Press

    Shaped by Quantum Theory, Technology, and the Genomics Revolution

    The integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. The second volume, Biomedical Diagnostics, focuses on biomedical diagnostic technologies and their applications from the bench to the bedside.

    Represents the Collective Work of over 150 Scientists, Engineers, and Clinicians

    Designed to display the most recent advances in instrumentation and methods, as well as clinical applications in important areas of biomedical photonics to a broad audience, this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of medical technologies.

    What’s New in This Edition:

    A wide variety of photonic biochemical sensing technologies have already been developed for clinical monitoring of physiological parameters, such as blood pressure, blood chemistry, pH, temperature, and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics, proteomics and metabolomics allow sensing of early disease state biomarkers, thus revolutionizing the medicine of the future. Nanobiotechnology has opened new possibilities for detection of biomarkers of disease, imaging single molecules and in situ diagnostics at the single cell level. In addition to these state-of-the art advancements, the second edition contains new topics and chapters including:

    • Fiber Optic Probe Design

    • Laser and Optical Radiation Safety

    • Photothermal Detection

    • Multidimensional Fluorescence Imaging

    • Surface Plasmon Resonance Imaging

    • Molecular Contrast Optical Coherence Tomography

    • Multiscale Photoacoustics

    • Polarized Light for Medical Diagnostics

    • Quantitative Diffuse Reflectance Imaging

    • Interferometric Light Scattering

    • Nonlinear Interferometric Vibrational Imaging

    • Multimodality Theranostics Nanoplatforms

    • Nanoscintillator-Based Therapy

    • SERS Molecular Sentinel Nanoprobes

    • Plasmonic Coupling Interference Nanoprobes

    Comprised of three books: Volume I: Fundamentals, Devices, and Techniques; Volume II: Biomedical Diagnostics; and Volume III: Therapeutics and Advanced Biophotonics, this second edition contains eight sections, and provides introductory material in each chapter. It also includes an overview of the topic, an extensive collection of spectroscopic data, and lists of references for further reading.

    Biomedical Analysis, Sensing and Imaging

    Biosensors for Medical Applications

    Tuan Vo-Dinh, Leonardo Allain and Andrew Fales

    Glucose Monitoring

    Casey W. Pirnstill, Brian Cummins, Gerard L. Coté, Roger J. McNichols

    Biochips and MicroArrays: Tools for the New Medicine

    Tuan Vo-Dinh and G. D. Griffin

    Atomic Spectroscopy for Biological and Clinical Analysis

    Andrew Taylor

    Flow Cytometry

    Francis Mandy, Joe Trotter, Rudi Varro, Ming Yan, and Diether Recktenwald

    Capillary Electrophoresis Techniques in Biomedical Analysis

    S. Douglas Gilman and Michael J. Sepaniak

    Surface Plasmon Resonance Imaging: Principle, Development, and Biomedical Applications

    Julien Moreau, Jean-Pierre Cloarec, Paul Charette, Michel Goossens, Michael Canva, Tuan Vo-Dinh

    Surface-Enhanced Raman Scattering (SERS) for Biomedical Diagnostics

    Tuan Vo-Dinh and David L. Stokes

    Functional Imaging with Diffusing Light

    Arjun G. Yodh and David A. Boas

    Molecular Contrast Optical Coherence Tomography

    Oscar Carrasco-Zevallos, and Joseph Izatt

    Multiscale Photoacoustic Microscopy and Macroscopy, Song Hu and Lihong V. Wang

    Polarized light for Medical Diagnostics

    Steven L. Jacques

    X-Ray Diagnostic Techniques

    Xizeng Wu, Molly. D. Wong, Abby E. Deans and Hong Liu

    Optical Pumping and MRI of Hyperpolarized Spins

    Xizeng Wu, Thomas Nishino and Hong Liu

    Biomedical Diagnostics and Optical Biopsy

    Fluorescence Spectroscopy for Biomedical Diagnostics

    Tuan Vo-Dinh and Brian M. Cullum

    Elastic-Scattering Spectroscopy and Diffuse Reflectance

    Judith R. Mourant and Irving J. Bigio

    Quantitative Diffuse Reflectance Imaging of Tumor Margins

    Bing Yu, Nirmala Ramanujam

    Near Infrared Fluorescence Imaging and Spectroscopy in Random Media and Tissues

    E.M. Sevick-Muraka, E. Kuwana, A. Godavarty, J.P. Houston, A.B. Thompson, R.Roy

    Interferometric light scattering techniques for measuring nuclear morphology and detecting dysplasia

    Yizheng Zhu, Francisco E. Robles, Neil G. Terry, and Adam Wax

    Ultrasonically Modulated Optical Imaging

    François Ramaz, Emmanuel Bossy, Michel Gross and A. Claude Boccara

    Optoacoustic Tomography

    Alexander A. Oraevsky and Alexander A. Karabutov

    Raman Spectroscopy: From Benchtop to Bedside Anita Mahadevan-Jansen

    Fourier Transform Infrared (FTIR) Microspectroscopic Methods for Biomedical Analyses: From Single Point Detection to Two-Dimensional Imaging

    Rohit Bhargava and Ira W. Levin

    Photon Migration Spectroscopy Frequency-Domain Techniques

    Albert E. Cerussi and Bruce J. Tromberg


    Tuan Vo-Dinh is the R. Eugene and Susie E. Goodson Distinguished Professor of biomedical engineering, professor of chemistry, and director of the Fitzpatrick Institute for Photonics at Duke University. He received a B.S. in physics in 1970 from EPFL (Ecole Polytechnique Federal de Lausanne) in Lausanne and a Ph.D. in physical chemistry in 1975 from ETH (Swiss Federal Institute of Technology) in Zurich, Switzerland. Dr. Vo-Dinh has authored over 350 publications in peer-reviewed scientific journals. He is the author of a textbook on spectroscopy and editor of 6 books. He has received numerous awards and holds over 37 U.S. and international patents.