1st Edition

Biomedical Photonics for Diabetes Research

Edited By Andrey Dunaev, Valery V. Tuchin Copyright 2023
    278 Pages 164 B/W Illustrations
    by CRC Press

    In 2021, over 537 million people worldwide were diagnosed with diabetes, according to the International Diabetes Federation and so the diagnosis, care and treatment of patients with diabetes mellitus have become one of the highest healthcare priorities. Biomedical photonics methods have been found to significantly improve and assist in the diagnosis of various disorders and complications arising from diabetes. These methods have also been widely used in various studies in the field of diabetes, including in the assessment of biochemical characteristics, metabolic processes, and microcirculation that are impaired in this disease.

    This book provides an introduction to methods of biomedical photonics. The chapters, written by world-leading experts, cover a wide range of issues, including the theoretical basis of different biophotonics methods and practical issues concerning the conduction of experimental studies to diagnose disorders associated with diabetes. It provides a comprehensive summary of the recent advances in biomedical optics and photonics in the study of diabetes and related complications.

    This book will be of interest to biomedical physicists and researchers, in addition to practicing doctors and endocrinologists looking to explore new instrumental methods for monitoring the effectiveness of patient treatment.


    • The first collective book combining accumulated knowledge and experience in the field of diabetes research using biophotonics.

    • Contributions from leading experts in the field.

    • Combines the theoretical base of the described methods and approaches, as well as providing valuable practical guidance and the latest research from experimental studies.

    Chapter 1. Optical and Structural Properties of Biological Tissues under Simulated Diabetes Mellitus Conditions. Chapter 2. Optical Methods in Diabetic Foot Ulcer Screening. Chapter 3. The use of capillaroscopy and aggregometry methods to diagnose the alterations of microcirculation and microrheology in diabetes . Chapter 4. Diagnostics of functional abnormalities in the microcirculation system using laser Doppler flowmetry Chapter 5. Wearable sensors for blood perfusion monitoring in patients with diabetes mellitus. Chapter 6. Optical angiography at diabetes. Chapter 7. Noninvasive sensing of serum sRAGE and glycated hemoglobin by skin UV-induced fluorescence. Chapter 8. Hyperspectral imaging of diabetes mellitus skin complications. Chapter 9. Fluorescent technology in the assessment of metabolic disorders in diabetes. Chapter 10. Terahertz time-domain spectroscopy in the assessment of diabetic complications. Chapter 11. Noninvasive photonic sensing of glucose in blood stream.


    Andrey V. Dunaev is a Professor and a Leading Researcher at the Research and Development Center of Biomedical Photonics at Orel State University (Orel, Russia). His research interests are devoted to multimodal optical diagnostics of microcirculatory-tissue systems, including methodological and metrological support of diagnostic systems.

    He is a member of SPIE. Professor Dunaev is an Honorary Worker of Science and High Technologies of the Russian Federation.

    He is an author of more than 100 papers in peer-reviewed journals, 5 monographs and has over 10 patents.

    Valery V. Tuchin is a corresponding member of the Russian Academy of Sciences, Professor, Head of the Department of Optics and Biophotonics and Director of the Science Medical Center of Saratov State University. He is also Head of the Laboratory for Laser Diagnostics of Technical and Living Systems at the Institute of Precision Mechanics and Control, FRC "Saratov Scientific Center of the Russian Academy of Sciences."

    His research interests include biophotonics, biomedical optics, tissue optics, laser medicine, tissue optical clearing, and nanobiophotonics.

    He is a member of SPIE, OSA, and IEEE, Visiting Professor at HUST (Wuhan) and Tianjin Universities in China, and an Adjunct Professor at the University of Limerick (Ireland) and the National University of Ireland (Galway).

    Professor Tuchin is elected Fellow SPIE and OSA (OPTICA), he was awarded many titles and awards, including Honored Scientist of the Russian Federation, Honored Professor of SSU, Honored Professor of Finland (FiDiPro), SPIE Educational Award, Chime Bell Award of Hubei province (China), Joseph Goodman Award (OSA / SPIE) for Outstanding Monograph (2015), Michael Feld Award (OSA) for Pioneering Research in Biophotonics (2019), the Medal of the D.S. Rozhdestvensky Optical Society (2018) and the A.M. Prokhorov medal of the Academy of Engineering Sciences named after A.M. Prokhorov (2021).

    He is the author of over 1000 articles, 30 monographs, and textbooks, has over 60 patents, his works have been cited over 33,800 times.

    The book—subtitled “New Prospects in Optical Imaging”—is unique in bringing together a number of diverse tissue optical clearing (TOC) topics, such as 3D imaging and the combination of TOC and optical imaging/spectroscopy for diagnostics, and presenting it all at a level suitable for graduate students in biophysics and engineering. This task is accomplished with an emphasis on both methodology and applications. I found the description of these basic biophotonics techniques particularly detailed and interesting. Although written by more than 100 contributors, the style of the book is generally clear and fluent.

    - Review by Christian Brosseau for Optics and Photonics News, Optica Fellow and professor of physics, Université de Bretagne Occidentale, Brest, France