1st Edition
Biomedical Research, Medicine, and Disease
Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient.
The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in the translation of diagnostic measures, pharmaceutical advances, biomarkers, diagnostics, and therapeutics.
This book is meant for researchers, scientists, healthcare professionals, industry, innovators, and students of biomedical sciences, as well as for those involved in the basic sciences, biochemistry, biotechnology, biophysics, and life sciences in general.
The volume comprehensively covers:
- Emerging technologies for health care
- Various aspects of biomedical research toward understanding of pathophysiology of the diseases
- Advances in improvement in diagnostic procedures and therapeutic tools
- The fundamental role of biomedical research in the development of new medicinal products
Section 1: Advancement in Techniques in Biomedical Science
- Recent Advancements in Biomedical Sciences and Their Health Care Applications
Reena Sharma, Mukesh Prasad, and Samir Mehndiratta
- Nanotechnology in Medicine: A Promising Future
Rajni Lasyal, Nikhil Kirtipal, and R.C. Sobti
- How Flow Cytometers Work: An Introduction for Biomedical Scientists
William Telford
- Multicolour Flow Cytometry and Panel Design
Zosia Maciorowski
- Digital Watermarking Techniques for Medical Image Security Using the Fuzzy Analytical Hierarchy Process
Masood Ahmad, Rajeev Kumar, Alka Agrawal, Raees Ahmad Khan
- Limbal Stem Cell Deficiency: Concurrent Approaches and Scope of Regenerative Stem Cell Therapy and Blood Derivatives
Pragya Shukla and Seemha Rai
- White Rot Exopolysaccharide: Avenues to Biomedical Applications
Deepak K. Rahi, Sonu Rahi, and Ekta Chaudhary
Section 2: Health, Disease, and Management
- Membrane Lipids from Cellular Barriers to Health and Homeostasis
Sukesh Chander Sharma
- Childhood Cataract: A Clinico-Social Profile
Deepak Jugran, Surabhi Khurana, Parul Chawla, and Jagat Ram
- Evidence-Based Practice in Neurodegenerative Disorders: Approaches and Challenges
Mani Chopra, Sweety Mehra, Era Seth, Aitizaz Ul Ahsan, and R.C. Sobti
- Pragmatic Utilization of Technology in Dentistry: Current Status and Future Perspectives
Jagat Bhushan, Ruchi Singla, Aastha Sobti, Swaty Jhamb, and Kratika Chauhan
- Stress Deregulates Memory Consolidation Through Epigentic Modifications
Sukanya Tripathy and Anand Prakash
- The Management of Autism Spectrum Disorder: Challenges Ahead
Priya Joon, Anil Kumar, and Milind Parle
- Genetics of Left Ventricular Dysfunction in Coronary Artery Disease
Surendra Kumar, Avshesh Mishra, Anshika Srivastava, Rama Mittal, and Balraj Mittal
15. Genetics of Diabetic Nephropathy: A Review
Gurvinder Singh, Priyanka Raina, and A.J.S. Bhanwer
16. Human Y Chromosome: Genetic Markers, Implications, and Pathologies
Yogesh Thapen, Swarkar Sharma, Ekta Rai, and Vijay Kumar
17. Role of Repair Gene Polymorphism and Hypermethylation of GSTP Gene in the Risk of Prostate Cancer
Jagdeep S. Deep, Sukhjeet Sidhu, and R.C. Sobti
18. Lymphatic Filariasis-Visceral Leishmaniasis Coinfection
Vikas Kushwaha
19. Metabolic Dysregulation, Oncogenes, and Tumour Suppressors: A Highly Orchestrated Performance to Induce Carcinogenesis
Mani Chopra, Era Seth, Sanchita Khurana, and R. C. Sobti
20. Transthyretin Cardiac Amyloidosis: Recent Advances in Diagnosis and Treatment
Shreya Ghosh, Dibbendhu Khanra, and Ashwani Kumar Thakur
21. Pathophysiology of Diabetes-Induced Foot Ulcers and Therapy Options
Reena Badhwar, Harvinder Popli, Harpal S. Buttar, Vijay Bhalla, and Istvan G. Telessy
22. Current Challenges in Immunobiology of Autoimmunity and Cancer
Kumari Anupam, Jyotsana Kaushal, Ankit Tandon, and Archana Bhatnagar
23. Human Papillomavirus (HPV): Molecular Epidemiology of Infection and its Associated Diseases
Abhishek Pandeya, Raj Kumar Khalko, Bharti Kotarya, Hema, Jitendra Kumar Yadav, Sudipta Saha, Sunil Babu Gopiatala, and R.C. Sobti
24. Challenges of Multidrug Resistance Microbes on Public Health
Monika Sharma, Meghali Bharti, Sonakshi Modeel, Himani Khurana, Tarana Negi, and Ram Krishan Negi
25. Role of Probiotics in the Prevention and Management of Obesity: What Have We Learned So Far?
Tajpreet Kaur, Ashwani Kumar Sharma, Balbir Singh, Harpal Singh Buttar, and Amrit Pal Singh
Section 3 Therapeutics and Novel Approaches
26. Protease Inhibitors of Marine Origin: Promising Anticancer and HIV Therapies
Maushmi S. Kumar, Yashodhara Dalal, Sahil Khan, and Harpal S. Buttar
27. Skin Stem Cells: Therapeutic Potential in Vitiligo
Harjot Kaur, Naveed Pervaiz, Ravinder Kumar, and Davinder Parsad
28. Interplay of Cancer Associated Fibroblasts (CAFs) and Tumour-Associated Macrophages (TAMs) in Metastasis and Their Potential for Therapeutic Interventions
Indu Sharma and Anuradha Sharma
29. Lantibiotics: Strengthening Our Armor Against Antibiotic-Resistant Pathogens
Shweta Kishen, Mangal Singh, and Dipti Sareen
30.Traditional Medicines for the Control of Leishmaniasis: Experimental Studies
Jyoti Joshi, Rupinder Kaur, and Sukhbir Kaur
31. Metal-Embedded Complexes: Accelerated Antimicrobial Activity Against Microorganisms
Preeti Garg, Gurpreet Kaur, and Ganga Ram Chaudhary
Section 4 Drugs and Delivery Systems
32. Stem Cells: Emerging Novel Approaches to Drug Research and Disease Therapeutics
Shiv Bharadwaj, Nikhil Kirtipal, Meena Bharti, and R.C. Sobti
33. Bioinformatics Review in miRNA System Biology and Drug Discovery
Swati Srivastava, Ankita Sethia, and Vijay Laxmi Saxena
34. Biomaterial-Based Nanofibers for Drug Delivery Applications
Sneha Anand, P.S. Rajinikanth, Prashant Pandey, Payal Deepak, Sunita Thakur, Dilip Kumar Arya, and Shweta Jaiswal
35. Threapeutic Translational Potential of Surface-Decorated Nanoparticles
Nidhi Mishra, Raquibun Nisha, Ravi Raj, Pal Alka, Prem Singh, Neelu Singh, and Shubhini Saraf
Section V: Nutra-Chemistry
36. Towards Developing Biofortified Food Crops for Enhancing Nutritional Aspects and Human Health
Manu Priya and Harsh Nayyar
37. Production of Sesquiterpene Lactones in Family Asteraceae: Structure, Biosynthesis, and Applications
Savita Bains, Vasundhara Thakur, Kashmir Singh, and Ravneet Kaur
38. Multiple Therapeutic Applications of Pomegranate Fruit and its Bioactive Phytochemicals in Health and Disease
Mostafa Gouda, Laila Hussein, Douglas W. Wilson, and Harpal S. Buttar
Biography
Ranbir Chander Sobti, former Vice-Chancellor Panjab University, Chandigarh & Babasaheb Bhimrao Ambedkar University (Central University), Lucknow is a scientist, an able administrator, and dynamic institution builder.
He has published more than 350 papers in journals of national and international repute such as Mutation Research, Carcinogenesis, Archives of Toxicology, Cancer Genetics and Cytogenetics, Molecular Cell Biochemistry, and PLOS One to name a few. He has also published more than 50 books by international publishers such as Springer, Academic Press, CRC, Elsevier, and others.
He is Fellow of the Third World Academy of Sciences, National Academy of Sciences India, Indian National Science Academy, National Academy of Medical Sciences, National Academy of Agricultural Sciences, Canadian Academy of Cardiovascular Diseases, and a few others. He was the General President of the Indian Science Congress Association for the 102nd session, held at University of Jammu in 2013. He is the recipient of many prestigious awards, such as the INSA Young Scientist Medal, UGC Career Award, Punjab Rattan Award, JC Bose Oration and Sriram Oration Awards, and Lifetime Achievement Awards of the Punjab Academy of Sciences, Zoological Society of India, and the Environment Academy of India, besides many other medals and awards of national and international levels. He was awarded Padmashri, the third highest civilian award by the Government of India in 2009 for his contributions to the cause of education. He has widely travelled across the globle.
Dr. Sobti, an active researcher, is also steadfastly committed to the popularization of science in the community through popular lectures and community engagement programs.
Aastha Sobti has a master’s degree in clinical dentistry and oro-facial surgery (UK) and works in the field of head and neck cancers using her intellect and her background in oral and maxillofacial surgery to bring reforms that are required in the present multifarious surgical and research areas.
She has seven years of teaching and research experience and has published a number of papers in reputed journals. She has been awarded a number of prizes and medals for her exceptional work. She has attended and presented papers in international conferences in Croatia, Brazil, Canada, USA, Japan, Switzerland, and other countries.
