592 pages | 43 Color Illus. | 57 B/W Illus.
This book will examine the relevant biological subjects involved in biomimetic microengineering as well as the design and implementation methods of such engineered microdevices. Physiological topics covered include regeneration of complex responses of our body on a cellular, tissue, organ, and inter-organ level. Technological concepts in cell and tissue engineering, stem cell biology, microbiology, biomechanics, materials science, micro- and nanotechnology, and synthetic biology are highlighted to increase understanding of the transdisciplinary methods used to create the more complex, robust biomimetic engineered models. The effectiveness of the new bioinspired microphysiological systems as replacements for existing in vitro or in vivo models is explained through sections that include the protocols to reconstitute three-dimensional (3D) structures, recapitulate physiological functions, and emulate the pathophysiology of human diseases. This book will also discuss how researchers can discover bridge technologies for disease modeling and personalized precision medicine.
Emulating Biomechanical Environments in Microengineered Systems. Biomimetic Microsystems for Blood and Lymphatic Vascular Research. Multispecies microbial communities and synthetic microbial ecosystems. Stem Cell Engineering. Organoid Technology for Basic Science and Biomedical Research. Design, Fabrication, and Microflow Control Techniques for Organ-on-a-Chip Devices. Microfluidic techniques for high-throughput cell analysis. 3D Printing and Bioprinting Technologies. Microengineered Models of Human Gastrointestinal Diseases. Respiratory Pathophysiology - Microphysiological Models of Human Lung. In Vitro Alzheimer’s Disease Modeling Using Stem Cells. Manufacturing and Assembly of Micro- and Nano-scale Devices and Interfaces Using Silk Proteins. Microarray 3D Bioprinting for Creating Miniature Human Tissue Replicas for Predictive Compound Screening. Integration of the Immune system into Complex In Vitro Models for pre-clinical drug development