Bioreactor System Design  book cover
1st Edition

Bioreactor System Design

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ISBN 9780824790028
Published November 17, 1994 by CRC Press
648 Pages

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Book Description

Describes the state-of-the-art techniques and methods involved in the design, operation, preparation and containment of bioreactor systems, taking into account the interrelated effects of variables associated with both upstream and downstream stages of the design process. The importance of the initial steps in the development of a bioprocess, such as strain and media selection, that have an overwhelming influence on all further operations, is emphasized.;This work is intended for biochemical, chemical and bioprocess engineers; biotechnologists; industrial biochemists; micro- and molecular biologists; food scientists; and upper-level undergraduate and graduate students in these disciplines.

Table of Contents

Series Introduction W. Courtney McGregor

Foreword Eleftherios Terry Papoutsakis



Design of a Bioreactor System: Overview

José C. Merchuk and Juan A. Asenjo

Part I: Biological Systems and Media Design

Organism Selection

Francisco Javier Castillo

Bacterial, Yeast, and Fungal Cultures: Effect of Microorganism Type and Culture Characteristics on Bioreactor Design and Operation
Moshe D. White, Bernard R. Glick, and Campbell W. Robinson

Design, Formulation, and Optimization of Media

Rodolfo J. Ertola, Ana Maria Giulietti, and Francisco Javier Castillo

Part II: Bioreactor Design

Fundamentals of Bioreactor Design

José C. Merchuk and Juan A. Asenjo

Stirred Tank Bioreactors

Matthias Reuss

Pneumatically Agitated Bioreactors

Karl Schügerl and Andreas Lübbert

Membrane Reactors

Peter M. Salmon and Channing R. Robertson

Immobilized Microorganism Bioreactors

Hideki Fukuda

Immobilized Animal Cell Bioreactors

Matthew S. Croughaun, Tzyy-Wen Chiou, and Daniel I. C. Wang

Plant Cell Bioreactors

Peter D. G. Wilson and Martin G. Hilton


Aleś Prokop and Larry E. Erickson

Bioreactor Operation Modes

Tsuneo Yamane


Carles Solá and Francesc Gòdia

Part III: Bioreactor Support Systems

Sterilization and Containment

Andrew Sinclair and Michael H. J. Ashley

Bioreactor System Supplies

T. M. Roberts, M. J. Kearns, and T. J. Latham


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