Describes the state-of-the-art techniques and methods involved in the design, operation, preparation and containment of bioreactor systems, taking into account the interrelated effects of variables associated with both upstream and downstream stages of the design process. The importance of the initial steps in the development of a bioprocess, such as strain and media selection, that have an overwhelming influence on all further operations, is emphasized.;This work is intended for biochemical, chemical and bioprocess engineers; biotechnologists; industrial biochemists; micro- and molecular biologists; food scientists; and upper-level undergraduate and graduate students in these disciplines.
Design of a bioreactor system - overview. Part 1 Biological systems and media design: organism selection; bacterial, yeast, and fungal cultures - effect of microorganism type and culture characteristics on bioreactor design and operation; design, formulation, and optimization of media. Part 2 Bioreactor design: fundamentals of bioreactor design; stirred tank bioreactors; pneumatically agitated bioreactors; membrane reactors; immobilized microorganism bioreactors; immobilized animal cell bioreactors; plant cell bioreactors; photobioreactors; bioreactor operation modes; bioreactor scale-up. Part 3 Bioreactor support systems: sterilization and containment; bioreactor system supplies.