1st Edition

Biosensor Principles and Applications

By Blum Copyright 1991

    Considers a new generation of sensors for use in industrial processes, which measure the chemical environment directly by means of a biological agent mainly enzymes so far. Various specialists from Europe, the US, and Japan identify the device's place in their disciplines; review the principles of m

    Series Introduction



    What is a Biosensor?

    Pierre R. Coulet

    Amperometric Enzyme Electrodes for Substrate and Enzyme Activity Determinations

    Gilbert Bardeletti, Florence Sechaud and Pierre R. Coulet

    Development of Amperometric Biosensors for Enzyme Immunoassay

    J. V. Bannister, I. John Higgins and Anthony P. F. Turner

    Pontentiometric Enzyme Electrodes

    Jean-Michel Kauffman and George G. Guilbault

    Enzyme Thermistor Devices

    Bengt Danielsson

    Analytical Applications of Piezoelectric Crystal Biosensors

    John H. T. Luong and George G. Guilbault

    FET-Based Biosensors

    Toshihide Kuriyama and Jun Kimura

    Chemically Mediated Fiberoptic Biosensors

    Bernhard P. H. Schaffar and Otto S. Wolfbeis

    Fluorophore- and Chromophore-Based Fiberoptic Biosensors

    Mark A. Arnold

    Bioluminescence- and Chemiluminescence- Based Fiberoptic Sensors

    Loic J. Blum and Sabine M. Gautier


    Masuo Aizawa

    Microbial Biosensors

    I. Karube and M. E. SangMok Chang

    In Vivo Biosensors

    P. Vadgama and M. A. Desai

    Trends and Prospects

    Loic J. Blum and Pierre R. Coulet



    Loïc J. BLUM is Mâitre de Conférences in Biochemistry and Biotechnology at the Université Claude Bernard de Lyon, France. The author or coauthor of some 30 articles and book chapters, he has concentrated on research in immobilized enzymes on membrane supports, heterogeneous enzymology and the role of mass transfer on enzyme kinetics, bioluminescence and chemiluminescence reactions in the heterogeneous phase, and the development of fiber optic biosensors. Dr. Blum received the doctorat de spécialité (1983) in biochemistry and the doctorat d’état ès sciences (1991) from the Université Claude Bernard de Lyon`., PIERRE R. COULET is Professor of Biochemistry and Biotechnology, and head of the enzyme engineering laboratory at the Université Claude Bernard de Lyon, France. From 1974 to 1983 he served as a researcher at the CNRS (National Center for Scientific Research). The author or coauthor of some 100 articles, reviews, and book chapters, he investigates enzyme engineering and biosensors, including heterogeneous enzymology and membrane-bound enzymes, membrane reactors, and amperometric and optical biosensors. He is an editorial board member of the journals Analytical Letters (Marcel Dekker, Inc.), Analusis, and Analytica Chimica Acta. Professor Coulet received the doctorat de spécialité (1973) in chemistry and biochemistry, and the doctorat d’état ès sciences (1978) from the Université Claude Bernard de Lyon.